DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRIT2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001271152.1	Gene:	LRIT2 / 340745	HGNCID:	23443	Length:	560	Species:	Homo sapiens

Alignment Length:	498	Identity:	125/498 - (25%)
Similarity:	205/498 - (41%)	Gaps:	74/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCT 110
            |.|...|..::..|.:.:|.|||.::|.|.:.:...::.:.|:.:..|:  .:..:..::|....
Human    28 CTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFI--NMSTLEYLWLNFNN 90

  Fly   111 IQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSR 175
            |..:|..|.:.|..|.||.|.||::..:....|.....||.:.:..|:|:.||......|..|:.
Human    91 ISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTY 155

  Fly   176 IEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDF 240
            ::..:|||..|...||     |:..:.::.|......|....|...:|    .|.|.|.|.|:..
Human   156 LDLSSNRLTVVSKSVF-----LNWPAYQKCRQPDCGAEILSSLVVALH----DNPWVCDCRLRGL 211

  Fly   241 RDFAISKRLYTPPT-------DCQEPPQLRGKLWSEVPSENFAC-RPRI-LGSVRSFIEANHDNI 296
            ..|..|   .|.|.       .||.|....|:|:.|  :|..|| :|:| ..|....|.|. .|:
Human   212 VQFVKS---ITLPVILVNSYLICQGPLSKAGQLFHE--TELSACMKPQISTPSANITIRAG-QNV 270

  Fly   297 SLPCRIVGSPRPNVTWVYNKRPLQQYDPRV------RVLTSVEQMPEQPSQVLTSELRIVGVRAS 355
            :|.|....||.|::.|.|.....:::|..:      .||||     ........|||.|......
Human   271 TLRCLAQASPSPSIAWTYPLSMWREFDGLLGGKHLTPVLTS-----STGEDTALSELAIPAAHLV 330

  Fly   356 DKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTL 420
            |.|.|||:|.|..|::.....|.|..  |.|:.|.|.:        :|..:.|.::.:.::..|:
Human   331 DSGNYTCMASNSIGKSNLVISLHVQP--AQALHAPDSL--------SIPSEGNAYIDLRVVKQTV 385

  Fly   421 --LLLLLVAV--------LTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEM 475
              :||..:||        .||  |....:.::|:...: |.|:.:..:|....|:..|..:.:|.
Human   386 HGILLEWLAVADTSKEEWFTL--YIASDEAFRKEVVHI-GPGINTYAVDDLLPGTKYEACLSLEG 447

  Fly   476 QKSLLNEVNPVEKPPRRTDIESVDGGDDV--LEIKKTLLDDTV 516
            |            ||.:....:...|.|.  ||.::.||..||
Human   448 Q------------PPHQGQCVAFVTGRDAGGLEAREHLLHVTV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	17/83 (20%)
		leucine-rich repeat	76..100	CDD:275380	2/23 (9%)
		LRR_8	99..159	CDD:290566	15/59 (25%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	15/58 (26%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	197..>229	CDD:290566	5/31 (16%)
		leucine-rich repeat	197..220	CDD:275380	4/22 (18%)
		LRRCT	229..277	CDD:214507	16/54 (30%)
		Ig	296..376	CDD:143165	24/85 (28%)
LRIT2	NP_001271152.1	leucine-rich repeat	37..55	CDD:275380	5/17 (29%)
		leucine-rich repeat	58..80	CDD:275378	2/23 (9%)
		LRR_8	60..115	CDD:290566	13/56 (23%)
		LRR_RI	<75..164	CDD:238064	23/90 (26%)
		LRR 1	80..103		4/22 (18%)
		LRR_4	81..119	CDD:289563	11/37 (30%)
		leucine-rich repeat	81..104	CDD:275378	5/22 (23%)
		LRR_8	103..163	CDD:290566	16/59 (27%)
		LRR 2	104..125		7/20 (35%)
		leucine-rich repeat	105..128	CDD:275378	7/22 (32%)
		LRR 3	128..149		6/20 (30%)
		leucine-rich repeat	129..152	CDD:275378	7/22 (32%)
		LRR 4	152..173		7/25 (28%)
		leucine-rich repeat	153..164	CDD:275378	3/10 (30%)
		leucine-rich repeat	193..204	CDD:275378	4/14 (29%)
		TPKR_C2	200..243	CDD:301599	14/45 (31%)
		I-set	253..354	CDD:254352	31/106 (29%)
		IGc2	267..344	CDD:197706	24/82 (29%)
		FN3	377..440	CDD:214495	13/65 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAUD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810