DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and slitrk6

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001292482.1	Gene:	slitrk6 / 324096	ZFINID:	ZDB-GENE-030131-2816	Length:	830	Species:	Danio rerio

Alignment Length:	338	Identity:	76/338 - (22%)
Similarity:	125/338 - (36%)	Gaps:	96/338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GTTDWMQSCG-----TCHCQWNSGKKSADCKNKALT-----KIPQDMSNEMQVLDFAHNQIPELR 89
            |.|:...|.|     .|.|:...|....:|:.:.::     |:|.|:...   |:...|.:.||.
Zfish    26 GDTESKASYGGACKSLCTCEEKDGVLYVNCEERNISRISDVKVPSDVPFH---LNLYKNDLVELL 87

  Fly    90 REEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVII 154
            .|:.                       ||||.   .|.|.|..|.|:||.||.|:.|..|:.:.|
Zfish    88 AEDV-----------------------EAFKN---AITLHLGANSIQELEPGVFSALGSLKKLHI 126

  Fly   155 NNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFK--- 216
            |:|.:.:|....|..|..|..::...|.:|.|:...|:..:.|..:.|..|.:..|....|:
Zfish   127 NSNFLVMLKEDTFQGLVNLEYLQADTNFIRVVEPGAFSKLIRLKVLILNDNSIDFLPSNIFRFVP 191

  Fly   217 ----DLQ-----------------KLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD--CQE 258
                ||:                 ::|.|.|:.|.|.|:||:...:.:..:.|..:...:  |.:
Zfish   192 LTHLDLRGNKLQTLPYVGFLEHIGRIMELLLEDNDWVCNCEILHLKVWIENMRAQSSIGEVVCNK 256

  Fly   259 PPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYD 323
            |..|:|...:.|..::..              .:|.:|:|                 :.|||..|
Zfish   257 PENLKGTSLARVKRDSLC--------------PSHADINL-----------------EEPLQSQD 290

  Fly   324 PRVRVLTSVEQMP 336
            ..|...|.|.|:|
Zfish   291 MVVTPSTKVVQIP 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	24/83 (29%)
		leucine-rich repeat	76..100	CDD:275380	5/23 (22%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	4/22 (18%)
		LRR	122..145	CDD:197688	10/22 (45%)
		leucine-rich repeat	125..148	CDD:275380	11/22 (50%)
		LRR_8	148..207	CDD:290566	15/58 (26%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	10/55 (18%)
		leucine-rich repeat	197..220	CDD:275380	7/46 (15%)
		LRRCT	229..277	CDD:214507	11/49 (22%)
		Ig	296..376	CDD:143165	11/41 (27%)
slitrk6	NP_001292482.1	leucine-rich repeat	75..96	CDD:275380	8/46 (17%)
		LRR_8	76..129	CDD:290566	23/78 (29%)
		leucine-rich repeat	97..120	CDD:275380	11/22 (50%)
		LRR_8	120..179	CDD:290566	15/58 (26%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_8	168..226	CDD:290566	10/57 (18%)
		leucine-rich repeat	169..189	CDD:275380	5/19 (26%)
		leucine-rich repeat	192..281	CDD:275380	17/102 (17%)
		leucine-rich repeat	217..229	CDD:275378	5/11 (45%)
		TPKR_C2	225..>262	CDD:301599	9/36 (25%)
		leucine-rich repeat	282..379	CDD:275380	10/39 (26%)
		LRR_8	379..438	CDD:290566
		LRR_4	380..419	CDD:289563
		leucine-rich repeat	380..403	CDD:275380
		LRR_4	403..443	CDD:289563
		leucine-rich repeat	404..427	CDD:275380
		leucine-rich repeat	428..446	CDD:275380
		leucine-rich repeat	475..499	CDD:275380
		TPKR_C2	508..>544	CDD:301599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910