DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and Amigo3

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_796249.1 Gene:Amigo3 / 320844 MGIID:2444854 Length:508 Species:Mus musculus


Alignment Length:504 Identity:108/504 - (21%)
Similarity:150/504 - (29%) Gaps:196/504 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLLGVLVVLM-----------ALPPPTAGTTDWMQSCGTCHCQWNSGKKSAD---CKNKALTKI 67
            |:|.|:|:.::           .|||......|      .|.|       :||   |..:.|..:
Mouse     4 LVLSGILLCMLGAGLGTSDLEDVLPPAPHNCPD------ICIC-------AADVLSCAGRGLQDL 55

  Fly    68 PQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSG 132
            |                           ..||..                       ..|||||.
Mouse    56 P---------------------------VALPTT-----------------------AAELDLSH 70

  Fly   133 NRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMAL 197
            |.::.||||..|.|.:||.:.:..|::|||.:..|.|.|.|..::..:|.||.:..|...|...|
Mouse    71 NALKRLHPGWLAPLSRLRALHLGYNKLEVLGHGAFTNASGLRTLDLSSNMLRMLHTHDLDGLEEL 135

  Fly   198 SAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFR---------------DFA--- 244
            ..:.|..|.|.||..:.|:.|:.|.||.|..|      ||..|.               |.:   
Mouse   136 EKLLLFNNSLMHLDLDAFQGLRMLSHLYLSCN------ELSSFSFNHLHGLGLTRLRTLDLSSNW 194

  Fly   245 ---------------ISKRLY---TP-PTDCQEPPQLRGKLWSEVP-------SENFAC------ 277
                           :..|||   .| |.||.....||  .|.:..       ...:.|      
Mouse   195 LKHISIPELAALPTYLKNRLYLHNNPLPCDCSLYHLLR--RWHQRGLSALHDFEREYTCLVFKVS 257

  Fly   278 --RPRILGSVRSF--------------IEANHDNISLPCRI---VGSPRPNVTWVYNKRPL---- 319
              |.|.....|.|              .|..|..:....|:   ...|...|.||..|..|    
Mouse   258 ESRVRFFEHSRVFKNCSVAAAPGLELPEEQLHAQVGQSLRLFCNTSVPATRVAWVSPKNELLVAP 322

  Fly   320 QQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYA 384
            ...|..:.||..             ..|.|..|:....|.:.|:|.  |.|......|    :|.
Mouse   323 ASQDGSIAVLAD-------------GSLAIGRVQEQHAGVFVCLAS--GPRLHHNQTL----EYN 368

  Fly   385 GAVSASDGMGMGAIGAPTIDPQTNMF------LIICLIITTLLLLLLVA 427
            .:|..:             .|:...|      |:.|::...|:||.|.|
Mouse   369 VSVQKA-------------RPEPETFNTGFTTLLGCIVGLVLVLLYLFA 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 17/83 (20%)
leucine-rich repeat 76..100 CDD:275380 1/23 (4%)
LRR_8 99..159 CDD:290566 16/59 (27%)
leucine-rich repeat 101..124 CDD:275380 0/22 (0%)
LRR 122..145 CDD:197688 10/22 (45%)
leucine-rich repeat 125..148 CDD:275380 12/22 (55%)
LRR_8 148..207 CDD:290566 18/58 (31%)
leucine-rich repeat 149..172 CDD:275380 8/22 (36%)
leucine-rich repeat 173..196 CDD:275380 6/22 (27%)
LRR_8 197..>229 CDD:290566 12/31 (39%)
leucine-rich repeat 197..220 CDD:275380 8/22 (36%)
LRRCT 229..277 CDD:214507 15/91 (16%)
Ig 296..376 CDD:143165 18/86 (21%)
Amigo3NP_796249.1 leucine-rich repeat 44..61 CDD:275380 4/43 (9%)
LRR_RI <49..>221 CDD:238064 51/227 (22%)
LRR 1 62..83 10/43 (23%)
LRR_8 65..121 CDD:290566 23/55 (42%)
leucine-rich repeat 65..86 CDD:275380 12/20 (60%)
LRR 2 86..107 7/20 (35%)
leucine-rich repeat 87..110 CDD:275380 8/22 (36%)
LRR 3 110..133 6/22 (27%)
leucine-rich repeat 111..134 CDD:275380 6/22 (27%)
LRR 4 134..155 7/20 (35%)
leucine-rich repeat 135..158 CDD:275380 8/22 (36%)
LRR_8 142..193 CDD:290566 15/56 (27%)
LRR 5 158..178 8/25 (32%)
leucine-rich repeat 159..184 CDD:275380 8/30 (27%)
LRR 6 184..207 1/22 (5%)
leucine-rich repeat 185..209 CDD:275380 1/23 (4%)
IG_like 286..371 CDD:214653 22/103 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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