DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrfn2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001034788.1	Gene:	Lrfn2 / 316205	RGDID:	1311831	Length:	788	Species:	Rattus norvegicus

Alignment Length:	703	Identity:	152/703 - (21%)
Similarity:	237/703 - (33%)	Gaps:	174/703 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSCGT-CHCQWNSGKKSADCKNKALTKIPQDMSNEMQVL 78
            |..||.|:|...||...        :.:|.. |.||..|......|.:|.|..:|.|:......|
  Rat     1 METLLGGLLAFGMAFAV--------VDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVEL 57

  Fly    79 DFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTF 143
            ....|.|..:.|::|  |.:..:..:.|...||..:...:|..|..|..|.|..||:..|...|.
  Rat    58 RLGGNFIIHIGRQDF--ANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL 120

  Fly   144 AGLEKLRNVIINNNEIEVLPNHLFVN-LSFLSRIEFRNNRL---------RQVQLHVFAGTMALS 198
            .||..|:::|:|||::..:.:..|.: |..|..::...|.|         |.|.||
  Rat   121 RGLVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH--------- 176

  Fly   199 AISLEQNRLSHLHKETFKDLQKLMHLSLQ-----------------------------------G 228
            .:||:.|.|.|:.:.||.|||||..|.|.                                   |
  Rat   177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASLLTATPFAPPLSFSFGG 241

  Fly   229 NAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGS-VRSFIEAN 292
            |..:|:|||...|.......|.|    |..|..|:|:.:..:..|.|.|.|.::.. ....:...
  Rat   242 NPLHCNCELLWLRRLERDDDLET----CGSPGGLKGRYFWHIREEEFVCEPPLITQHTHKLLVLE 302

  Fly   293 HDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDK 357
            ....:|.|:.:|.|.|.:.||.....|.....|..|..:             ..|.|:...:.|.
  Rat   303 GQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDN-------------GTLDILITTSQDS 354

  Fly   358 GAYTCVADNRGGRAEAEFQLLV-------------------SGDYAGAVSASDGMGMGAIGAPTI 403
            |.:||:|.|..|.|.|..::.:                   ..|..|:...|.|.|....|.|..
  Rat   355 GPFTCIAANAAGEATATVEVSIVQLPHLSNSTSRMAPPKSRLSDITGSSKTSRGGGGSGAGEPPK 419

  Fly   404 DPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLE 468
            .......|:..:..|:.|:...|:.     ...|:|.||.... .|.|.::..:|....|.:.:.
  Rat   420 STPERAVLVSDVTTTSALVKWSVSK-----SAPRVKMYQLQYN-CSDDEVLIYRMIPASNKAFVV 478

  Fly   469 GSVI------------MEMQKSLLNEVNPV---------EKPPRRTDIESVDGGDDVLE----IK 508
            .:::            .:...:.|...|.|         :.|..::....:.||..:|.    |.
  Rat   479 NNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIV 543

  Fly   509 KTLLDDTVY------VANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFP-ARVP 566
            .|||...|.      |.||....:..:..:|:..:...           .:.||.|...| .::|
  Rat   544 ATLLVFIVILMVRYKVCNHDAPGKMAAATVSNVYSQTN-----------GAQPPPLGGMPVGQLP 597

  Fly   567 PTSPSM------------------QSSQSNIPDQVIYGI-----RSPPSLTSP 596
            ...|.:                  .||.|::......|:     |.||....|
  Rat   598 QAPPKVVVRNELMDFSTSLARACDSSSSSSLGSGEAAGLSRGPWRLPPPAPRP 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	17/68 (25%)
		leucine-rich repeat	149..172	CDD:275380	7/23 (30%)
		leucine-rich repeat	173..196	CDD:275380	7/31 (23%)
		LRR_8	197..>229	CDD:290566	14/66 (21%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		LRRCT	229..277	CDD:214507	14/47 (30%)
		Ig	296..376	CDD:143165	21/79 (27%)
Lrfn2	NP_001034788.1	LRR_RI	27..>209	CDD:238064	56/192 (29%)
		LRR 1	53..74		5/22 (23%)
		leucine-rich repeat	54..77	CDD:275380	6/24 (25%)
		LRR_8	76..136	CDD:290566	19/59 (32%)
		LRR 2	77..98		4/20 (20%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		LRR 3	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		LRR_8	125..185	CDD:290566	17/68 (25%)
		LRR 4	125..146		6/20 (30%)
		leucine-rich repeat	126..150	CDD:275380	7/23 (30%)
		LRR 5	150..171		3/20 (15%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		LRR_8	174..>215	CDD:290566	16/49 (33%)
		LRR 6	174..195		9/29 (31%)
		leucine-rich repeat	175..198	CDD:275380	11/31 (35%)
		LRR 7	198..219		4/20 (20%)
		LRRCT	242..286	CDD:214507	14/47 (30%)
		IG_like	298..376	CDD:214653	21/90 (23%)
		Ig	303..376	CDD:299845	21/85 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..423		7/39 (18%)
		fn3	428..493	CDD:278470	11/70 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..655		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..707
		PDZ-binding	785..788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910