DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and Amigo3

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_835280.1 Gene:Amigo3 / 316003 RGDID:631413 Length:508 Species:Rattus norvegicus


Alignment Length:478 Identity:102/478 - (21%)
Similarity:153/478 - (32%) Gaps:165/478 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNE----MQVLDFAHNQIPELRREEFLLAGLP 99
            |:...|...|...:|..::|.:. .|...|.:..|:    ..||..|...:.:|.      |.||
  Rat     3 WLVLLGLLLCMLGAGSGTSDLEG-VLPPDPHNCPNKCVCAADVLSCAGRGLQDLP------AALP 60

  Fly   100 NVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPN 164
            ..                       ..|||||.|.::.||||..|.|.:||.:.:..|:::||..
  Rat    61 AT-----------------------AAELDLSHNALKRLHPGWLAPLSRLRALYLGYNKLDVLGR 102

  Fly   165 HLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGN 229
            .:|.|.|.|..::..:|.||:::.:...|...|..:.|..|||.||..:.|:.|..|.||.|..|
  Rat   103 GVFTNASGLRILDLSSNLLRRLRTYDLDGLEELEKLLLFNNRLMHLDLDAFQGLSMLSHLYLSCN 167

  Fly   230 AWNCSCELQDFR---------------DFA------------------ISKRLY---TP-PTDCQ 257
                  ||..|.               |.:                  :..|||   .| |.||.
  Rat   168 ------ELSSFSFNHLHGLGLTRLRTLDLSSNWLGHVSVPELAALPTFLKNRLYLHNNPLPCDCS 226

  Fly   258 EPPQLRGKLWSEVP-------SENFACRP-RILGSVRSFIEANHDNISLPCRIVGS--------- 305
            ....||  .|.:..       ...:.|.. ::..|...|.|  |..:...|.:..:         
  Rat   227 LYHLLR--RWHQRGLSALHDFEREYTCLAFKVAESRVRFFE--HSRVFKNCSVAAAPGLELPEEE 287

  Fly   306 -----------------PRPNVTWVYNKRPL----QQYDPRVRVLTSVEQMPEQPSQVLTSELRI 349
                             |...|.||..|..|    ...|..:.||..             ..|.|
  Rat   288 LHTHVGQSLRLFCNTTVPAARVAWVSPKNELLVAPGSQDGSIAVLAD-------------GSLAI 339

  Fly   350 VGVRASDKGAYTCVADNRGGRAE----AEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMF 410
            ..|:....|.:.|:|.  |.|..    .|:.:                   ::..|..:|:.  |
  Rat   340 GRVQEQHAGLFVCLAS--GPRLHHNQTLEYNV-------------------SVHKPRPEPEA--F 381

  Fly   411 ------LIICLIITTLLLLLLVA 427
                  |:.|::...|:||.|.|
  Rat   382 NTGFTTLLGCIVGLVLVLLYLFA 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 22/83 (27%)
leucine-rich repeat 76..100 CDD:275380 6/23 (26%)
LRR_8 99..159 CDD:290566 16/59 (27%)
leucine-rich repeat 101..124 CDD:275380 0/22 (0%)
LRR 122..145 CDD:197688 10/22 (45%)
leucine-rich repeat 125..148 CDD:275380 12/22 (55%)
LRR_8 148..207 CDD:290566 16/58 (28%)
leucine-rich repeat 149..172 CDD:275380 7/22 (32%)
leucine-rich repeat 173..196 CDD:275380 5/22 (23%)
LRR_8 197..>229 CDD:290566 13/31 (42%)
leucine-rich repeat 197..220 CDD:275380 9/22 (41%)
LRRCT 229..277 CDD:214507 15/91 (16%)
Ig 296..376 CDD:143165 19/113 (17%)
Amigo3NP_835280.1 LRR 1 62..83 10/43 (23%)
LRR_8 65..121 CDD:404697 22/55 (40%)
leucine-rich repeat 65..86 CDD:275380 12/20 (60%)
LRR 2 86..107 6/20 (30%)
leucine-rich repeat 87..110 CDD:275380 7/22 (32%)
LRR 3 110..131 4/20 (20%)
leucine-rich repeat 111..134 CDD:275380 5/22 (23%)
LRR 4 134..155 8/20 (40%)
leucine-rich repeat 135..158 CDD:275380 9/22 (41%)
LRR_8 142..193 CDD:404697 16/56 (29%)
LRR 5 158..178 8/25 (32%)
leucine-rich repeat 159..184 CDD:275380 8/30 (27%)
LRR 6 184..207 1/22 (5%)
leucine-rich repeat 185..208 CDD:275380 1/22 (5%)
Ig_3 279..355 CDD:404760 14/88 (16%)
Ig strand B 295..303 CDD:409353 0/7 (0%)
Ig strand C 308..313 CDD:409353 2/4 (50%)
Ig strand C' 316..318 CDD:409353 0/1 (0%)
Ig strand D 329..332 CDD:409353 0/2 (0%)
Ig strand E 335..342 CDD:409353 2/6 (33%)
Ig strand F 348..355 CDD:409353 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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