DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrfn5

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001101494.1	Gene:	Lrfn5 / 314164	RGDID:	1309357	Length:	719	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	188/943 - (19%)
Similarity:	294/943 - (31%)	Gaps:	369/943 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFA 81
            |.|:|:.|.....|.             .|.||..|...:..|..|.|..:|.::......|..|
  Rat     8 LFLIGIAVRAQICPK-------------RCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLA 59

  Fly    82 HNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGL 146
            .|.:..::|::|  |.:.::..:.|...||..:...||..|..|..|.|:.||:.::....|:||
  Rat    60 DNFVTNIKRKDF--ANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGL 122

  Fly   147 EKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRL---- 207
            ..|.::|:|||::.::.:..|.::..|..::...|.|..:........::|..:||:.|.:
  Rat   123 SNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIP 187

  Fly   208 ----SHLHKETFKD-----LQKL----------------------MHLSLQGNAWNCSCELQDFR 241
                |||||.|..|     ||||                      ..||..||..:|:|||...|
  Rat   188 KGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLR 252

  Fly   242 DFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRP----------RILGSVRSFIEANHDNI 296
            ..:....|.|    |..|..|.|:.:..:|.|.|.|.|          |:|...|:
  Rat   253 RLSREDDLET----CASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRA--------- 304

  Fly   297 SLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVL---TSELRIVGVRASDKG 358
            :|.|:..|.|.|.:.|:         .|..:::::..:     |.|.   |.::.|..|:  |.|
  Rat   305 TLRCKARGDPEPAIHWI---------SPEGKLISNATR-----SLVYDNGTLDILITTVK--DTG 353

  Fly   359 AYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLL 423
            |:||:|.|..|                  .|:..|.:..|..|
  Rat   354 AFTCIASNPAG------------------EATQTMDLHIIKLP---------------------- 378

  Fly   424 LLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEK 488
                                                                  .|||..|.:.:
  Rat   379 ------------------------------------------------------HLLNSTNNIHE 389

  Fly   489 P-PRRTDIE---------SVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRH 543
            | |..:||.         |...||..:                |:|:..|:.|.|.|.
  Rat   390 PDPGSSDISTSTKSGSNASSSNGDTKM----------------SQDKIVVAEASSSTA------- 431

  Fly   544 TYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSNIP--------------DQVIYGIRSPPSLT 594
                          ||.|            :.|.|||              |.::|.:..|.|.|
  Rat   432 --------------LLKF------------NFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKT 470

  Fly   595 SPVYTHMTPHGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQ 659
            ..| .::....:|....:....:|..:|  ..:|.:..|             |...:|.:...|.
  Rat   471 FLV-NNLASGTMYDLCVLAIYDDGITSL--TATRVVGCI-------------QFTTEQDYVRCHF 519

  Fly   660 QQQQ-------------------------------QQQQQQHPLATTSPFLPAPVVYSPATGVVM 693
            .|.|                               .....||.:...|.      |||...|..|
  Rat   520 MQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKVTKVSN------VYSQTNGAQM 578

  Fly   694 KQGYMTIPRKPRAPSWAPSTSGAAGH------------GSIQLSEFQSP--------------TS 732
            :...:|:|:.        .:..|.||            .:||.||..|.              ||
  Rat   579 QGCSVTLPQS--------MSKQAMGHEENAQCCKVASDSAIQSSETCSSQDSSTTTSALPPTWTS 635

  Fly   733 PNP------SETGTATTAELQAEPVYDNLGLRTTAGGNST-LNLTKIAGSQGGAGQQYSMRDRPL 790
            ..|      .:|||..:||.|:|.| .|:..:.|...||| |.|....               |.
  Rat   636 SAPVSQKQKRKTGTKPSAEPQSEAV-TNVESQNTNRNNSTALQLASCP---------------PD 684

  Fly   791 PATPSLTSVSSATNASKIYEPIHELIQQQQQLQ 823
            ..|...||..:.|..:.:...:.:.:|:.|:|:
  Rat   685 SVTEGPTSQRAHTKPNALLTNVDQNVQETQRLE 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	17/66 (26%)
		leucine-rich repeat	197..220	CDD:275380	12/35 (34%)
		LRRCT	229..277	CDD:214507	15/47 (32%)
		Ig	296..376	CDD:143165	20/82 (24%)
Lrfn5	NP_001101494.1	LRR 1	52..73		5/22 (23%)
		leucine-rich repeat	53..76	CDD:275380	6/24 (25%)
		PPP1R42	56..211	CDD:411060	43/156 (28%)
		LRR 2	76..97		5/20 (25%)
		leucine-rich repeat	77..100	CDD:275380	6/22 (27%)
		LRR 3	100..121		6/20 (30%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR 4	124..145		6/20 (30%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR 5	148..169		3/20 (15%)
		leucine-rich repeat	149..172	CDD:275380	3/22 (14%)
		LRR 6	172..193		4/20 (20%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR 7	196..217		7/20 (35%)
		leucine-rich repeat	197..215	CDD:275380	6/17 (35%)
		TPKR_C2	240..>272	CDD:417692	11/35 (31%)
		IgI_SALM5_like	287..374	CDD:409421	25/129 (19%)
		Ig strand B	304..308	CDD:409421	1/12 (8%)
		Ig strand C	317..321	CDD:409421	0/3 (0%)
		Ig strand E	340..344	CDD:409421	1/3 (33%)
		Ig strand F	354..359	CDD:409421	3/4 (75%)
		Ig strand G	367..370	CDD:409421	0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..416		8/32 (25%)
		FN3	421..494	CDD:419708	18/106 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..719		29/120 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910