DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrrc4b

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001258010.1	Gene:	Lrrc4b / 308571	RGDID:	1307121	Length:	709	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	170/856 - (19%)
Similarity:	263/856 - (30%)	Gaps:	310/856 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GVLVVLMALPPP-------------TAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDM 71
            |.|::|....||             ..|.:....|| ..|.|...:.:  ..|..:.|.::|..:
  Rat    24 GALLLLWLFSPPLRAGGGGVAVTSAAGGGSPPATSCPAACSCSNQASR--VICTRRELAEVPASI 86

  Fly    72 SNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIR 136
            ....:.|:...|.|..:|.:.|  ..|.::..:.|....::::...||.||..|..|:|..||:.
  Rat    87 PVNTRYLNLQENSIQVIRTDTF--KHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLT 149

  Fly   137 ELHPGTFAGLEKLRNVIINNNEIEVLPNHLF----------------------------VNLSFL 173
            .:....|..|.|||.:.:.||.||.:|::.|                            |||.:|
  Rat   150 TVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYL 214

  Fly   174 S-------------------RIEFRNNRLRQVQLHVFAGTMALSAI------------------- 200
            :                   .:|...|||..::...|.|..:|..:
  Rat   215 NLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLK 279

  Fly   201 SLEQNRLSH-----LHKETFKDLQKLMHLSLQGNAWNCSCE-------LQDFRDFAISKRLYTPP 253
            |||:..|||     |..:.|..|.:|..:.|..|.|:|:|:       |::           |.|
  Rat   280 SLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKE-----------TVP 333

  Fly   254 TD------CQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHD-NIS------LPCRIVGS 305
            ::      |..|..|:|:...|:...:|.|...::      :|...| |::      |.|| .|:
  Rat   334 SNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVI------VEPPTDLNVTEGMAAELKCR-TGT 391

  Fly   306 PRPNVTWVYNKRPLQQYDP-RVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGG 369
            ...:|.|:.....|..:.. |||:           |.:....|....|...|.|.|||:..|..|
  Rat   392 SMTSVNWLTPNGTLMTHGSYRVRI-----------SVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 445

  Fly   370 RAEAEFQLLVS------GDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAV 428
            ...|...|.||      ....|......|.|.|..|..|             ..||      |.|
  Rat   446 NTTASATLNVSAVDPVAAGGPGGGGPGGGGGAGGAGGYT-------------YFTT------VTV 491

  Fly   429 LTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRT 493
            .||                            :|..|.        |.|:....|    ::||..|
  Rat   492 ETL----------------------------ETQPGE--------EAQQPRGTE----KEPPGPT 516

  Fly   494 DIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDL 558
            ...:..||                     |.:.|...:.|.|...|||..            |..
  Rat   517 TDGAWGGG---------------------RPDAAAPASASTTAPAPRSSR------------PTE 548

  Fly   559 LAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAPHNGFMTLQ 623
            .||      |.|....:::.:.|           |...:.|.....|.:...|..|.
  Rat   549 KAF------TVPITDVTENALKD-----------LDDVMKTTKIIIGCFVAITFMAA-------- 588

  Fly   624 HPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPA 688
                  :.|:|          .::|::|.|.|.||...:..:      :......|||....|.|
  Rat   589 ------VMLVA----------FYKLRKQHQLHKHHGPTRTVE------IINVEDELPAASAVSVA 631

  Fly   689 TGVVMKQG-------YMTIPRKPR---------APSWAP-------STSGAAGHGSIQLSE---F 727
            ....:..|       ::.:|...|         |.::..       ...||.|.|...:.|   |
  Rat   632 AAAAVAGGAGVGGDSHLALPALERDHLNHHHYVAAAFKAHYGGNPGGGCGAKGPGLNSIHEPLLF 696

  Fly   728 QSPTSPNPSET 738
            :|.:..|..||
  Rat   697 KSGSKENVQET 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/83 (28%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	17/59 (29%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	23/124 (19%)
		leucine-rich repeat	149..172	CDD:275380	11/50 (22%)
		leucine-rich repeat	173..196	CDD:275380	7/41 (17%)
		LRR_8	197..>229	CDD:290566	12/55 (22%)
		leucine-rich repeat	197..220	CDD:275380	10/46 (22%)
		LRRCT	229..277	CDD:214507	13/60 (22%)
		Ig	296..376	CDD:143165	21/86 (24%)
Lrrc4b	NP_001258010.1	LRRNT	59..92	CDD:214470	6/34 (18%)
		LRR	<89..299	CDD:227223	45/211 (21%)
		LRR 1	89..110		5/22 (23%)
		leucine-rich repeat	90..113	CDD:275380	6/24 (25%)
		LRR 2	113..134		3/20 (15%)
		leucine-rich repeat	114..137	CDD:275380	5/22 (23%)
		LRR 3	137..158		6/20 (30%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		LRR 4	161..182		9/20 (45%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR 5	185..207		0/21 (0%)
		leucine-rich repeat	186..210	CDD:275380	0/23 (0%)
		LRR 6	210..231		3/20 (15%)
		leucine-rich repeat	211..232	CDD:275380	2/20 (10%)
		LRR 7	232..253		5/20 (25%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		LRR 8	256..277		1/20 (5%)
		leucine-rich repeat	257..280	CDD:275380	1/22 (5%)
		LRR 9	280..301		8/20 (40%)
		leucine-rich repeat	281..302	CDD:275380	7/20 (35%)
		LRRCT	313..363	CDD:214507	13/60 (22%)
		I-set	366..455	CDD:400151	25/106 (24%)
		Ig strand A	366..369	CDD:409353	0/8 (0%)
		Ig strand A'	373..376	CDD:409353	1/2 (50%)
		Ig strand B	382..389	CDD:409353	3/7 (43%)
		Ig strand C	395..400	CDD:409353	2/4 (50%)
		Ig strand C'	403..405	CDD:409353	0/1 (0%)
		Ig strand D	414..418	CDD:409353	2/14 (14%)
		Ig strand E	421..425	CDD:409353	1/3 (33%)
		Ig strand F	435..442	CDD:409353	3/6 (50%)
		Ig strand G	445..455	CDD:409353	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..552		20/106 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910