DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Amigo1

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_996764.1	Gene:	Amigo1 / 295365	RGDID:	1303079	Length:	493	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	126/582 - (21%)
Similarity:	203/582 - (34%)	Gaps:	161/582 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GMILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQV 77
            |:.||||.:.::|..:  ..||..  :.|| ..|.|..|    ...|..:.|..:||.:.....:
  Rat     9 GLWLLLLSLFLLLFEV--ARAGRP--VVSCPANCLCASN----ILSCSKQQLPNVPQSLPGYTAL 65

  Fly    78 LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGT 142
            ||.:||.:..| :.|:....|.|:|.:.|.:..:..:..|||..:..|..||||.|.:..|....
  Rat    66 LDLSHNNLSRL-KAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFL 129

  Fly   143 FAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRL 207
            |:||:.|..:::.||.|.|:..:.|.:::.|.::....|.:.:..|.:......|..::|.....
  Rat   130 FSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMISRFPLELIKDANRLPKLTLLDLSS 194

  Fly   208 SHLHKETFKDLQKL-----MHLSLQGNAWNCSCEL---------------QDFRD--FAI-SKRL 249
            :.|.|....|||||     ..|.|..|...|.|:|               .||::  :.: ||:|
  Rat   195 NKLKKLPLTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCVHSKKL 259

  Fly   250 YTPPT----DCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEAN-HDNISLPCRIVGSPRPN 309
            :...:    :|.|   .:...|                      ||: .|.:::.|
  Rat   260 HNVFSLDFFNCSE---YKESAW----------------------EAHLGDTLTITC--------- 290

  Fly   310 VTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQ--VLTSE---LRIVGVRASDKGAYTCVADNRGG 369
                   ...||...:|.|..|.||:..|.:.  |..||   |....|:..|.|.|||.|
  Rat   291 -------DTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYA----- 343

  Fly   370 RAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMF-----------------LIICLII 417
                                     ||.....|:..:..::                 |:.|::.
  Rat   344 -------------------------MGETFNETLSVELKVYNFTLHGHHDTLNTAYTTLVGCILS 383

  Fly   418 TTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVI---MEMQKSL 479
            ..|:|:.|.......| ||.:    :..:...||.|.||.:..|.|...:.|...   .:.:.:.
  Rat   384 VVLVLIYLYLTPCRCW-CRGV----EKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAF 443

  Fly   480 LNEVNPVE------KPPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDT 535
            |....|.:      ||.....:....|...                ....|.|:||...|||
  Rat   444 LEPAGPGQGQNGKLKPGNTLPVPEATGKGQ----------------RRMSDPESVSSVFSDT 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	26/83 (31%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	11/58 (19%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	11/36 (31%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	12/69 (17%)
		Ig	296..376	CDD:143165	20/84 (24%)
Amigo1	NP_996764.1	leucine-rich repeat	44..64	CDD:275380	4/19 (21%)
		LRR	53..>242	CDD:227223	49/189 (26%)
		LRR 1	62..83		6/21 (29%)
		leucine-rich repeat	65..87	CDD:275380	7/22 (32%)
		LRR 2	87..108		6/20 (30%)
		leucine-rich repeat	88..111	CDD:275380	5/22 (23%)
		LRR 3	111..132		8/20 (40%)
		leucine-rich repeat	112..135	CDD:275380	10/22 (45%)
		LRR 4	135..156		6/20 (30%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		LRR 5	159..179		3/19 (16%)
		leucine-rich repeat	160..186	CDD:275380	4/25 (16%)
		LRR 6	186..206		4/19 (21%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		IG_like	279..358	CDD:214653	26/124 (21%)
		Ig strand B	285..296	CDD:409353	2/26 (8%)
		Ig strand C	298..303	CDD:409353	1/4 (25%)
		Ig strand C'	307..309	CDD:409353	1/1 (100%)
		Ig strand D	318..321	CDD:409353	1/2 (50%)
		Ig strand E	324..331	CDD:409353	1/6 (17%)
		Ig strand F	337..345	CDD:409353	5/37 (14%)
		Ig strand G	348..358	CDD:409353	1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..493		20/101 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910