DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and Islr

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:XP_006511267.1 Gene:Islr / 26968 MGIID:1349645 Length:436 Species:Mus musculus


Alignment Length:436 Identity:105/436 - (24%)
Similarity:171/436 - (39%) Gaps:78/436 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GRRL-GMILLLLGVLVVLM-ALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMS 72
            ||.: .:.||...||:.|: |.|.|             |.|....|.:.|||..:.|..:|....
Mouse     6 GRTMRALCLLCWAVLLNLVRACPEP-------------CDCGEKYGFQIADCAYRDLEGVPPGFP 57

  Fly    73 NEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRE 137
            ..:..|..:.|::|          |||                ..||:.:.:|..|.|:.|.||.
Mouse    58 ANVTTLSLSANRLP----------GLP----------------EGAFREVPLLQSLWLAHNEIRS 96

  Fly   138 LHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISL 202
            :..|..|.|..|:::.:::|.:.........|||.|..::..:|.|..:....|:...||.::.|
Mouse    97 VAIGALAPLSHLKSLDLSHNLLSEFAWSDLHNLSALQLLKMDSNELAFIPRDAFSSLSALRSLQL 161

  Fly   203 EQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD---CQEPPQLRG 264
            ..|||..|.:.||..|..|.||.:..|.::|:|.:..|:.:|::..:..|..|   |..|..|:|
Mouse   162 NHNRLHALAEGTFAPLTALSHLQINDNPFDCTCGIVWFKTWALASAVSIPEQDNIACTTPHVLKG 226

  Fly   265 KLWSEVPSENFACRPRILGSVRSFIEANHDN--------ISLPCRIVGSPRPNVTWVYNKRP--- 318
                 :|.......|....||:...:.:.|.        ::|.|.:.|.|.|.:.| :...|   
Mouse   227 -----IPLGRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPVPQLHW-HIHTPGGT 285

  Fly   319 LQQYDPRV----RVLTSVEQMPEQP--SQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQL 377
            ::...|.|    |.|........||  .......|.|......::|.|:|:|.|..|.||:...:
Mouse   286 VEIASPNVGTDGRALPGALATSGQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVNV 350

  Fly   378 LVSGDYAGAVSA----SDGMGMGAIGAPTID-------PQTNMFLI 412
            .::....|...|    ..|..:...|..|:|       |:.|:.:|
Mouse   351 ALATPGEGGEDAVGHKFHGKAVEGKGCYTVDNEVQPSGPEDNVVII 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 19/83 (23%)
leucine-rich repeat 76..100 CDD:275380 5/23 (22%)
LRR_8 99..159 CDD:290566 14/59 (24%)
leucine-rich repeat 101..124 CDD:275380 2/22 (9%)
LRR 122..145 CDD:197688 7/22 (32%)
leucine-rich repeat 125..148 CDD:275380 9/22 (41%)
LRR_8 148..207 CDD:290566 13/58 (22%)
leucine-rich repeat 149..172 CDD:275380 4/22 (18%)
leucine-rich repeat 173..196 CDD:275380 4/22 (18%)
LRR_8 197..>229 CDD:290566 12/31 (39%)
leucine-rich repeat 197..220 CDD:275380 9/22 (41%)
LRRCT 229..277 CDD:214507 12/50 (24%)
Ig 296..376 CDD:143165 23/88 (26%)
IslrXP_006511267.1 leucine-rich repeat 40..59 CDD:275380 5/18 (28%)
LRR_8 59..118 CDD:338972 19/84 (23%)
leucine-rich repeat 60..83 CDD:275380 8/48 (17%)
leucine-rich repeat 84..107 CDD:275380 9/22 (41%)
LRR_8 107..166 CDD:338972 13/58 (22%)
leucine-rich repeat 108..131 CDD:275380 4/22 (18%)
leucine-rich repeat 132..155 CDD:275380 4/22 (18%)
leucine-rich repeat 156..179 CDD:275380 9/22 (41%)
PCC 161..>235 CDD:188093 23/78 (29%)
Ig 263..349 CDD:319273 23/86 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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