DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and SLITRK5

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001371538.1	Gene:	SLITRK5 / 26050	HGNCID:	20295	Length:	958	Species:	Homo sapiens

Alignment Length:	949	Identity:	192/949 - (20%)
Similarity:	325/949 - (34%)	Gaps:	271/949 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AGTTDWM-QSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQV--LDFAHNQIPELRREEFL 94
            |.|.|:. :.| ..|.|:...|..:..|:|:.:..:.:.......:  |..:.|.:..|...||:
Human    38 AETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFV 102

  Fly    95 -LAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNE 158
             ..|...:|   |.:..||::...||.||..|..|.|:.|::..|...||.|||.|..:.::.|.
Human   103 NYTGASILH---LGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNY 164

  Fly   159 IEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHL-HKETFKDLQKLM 222
            |.|:..:.|..|..|..:...:|.|..:..::|. .:.|:.:.|..|||..| :....:.:.|::
Human   165 ISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFR-FVPLTHLDLRGNRLKLLPYVGLLQHMDKVV 228

  Fly   223 HLSLQGNAWNCSCELQDFRDF--AISKRLYTPPTDCQEPPQLRGKLWSEVPSE---------NFA 276
            .|.|:.|.|||||||...:|:  :||.........|:.|.:|.|:...||..:         ::.
Human   229 ELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYE 293

  Fly   277 CRPRILGSVRSFIE---ANHDNISLPCRIVGSP---RPNVTWVYNK---RPLQQ----------Y 322
            .||:...|...::.   |:.::::.....|..|   .|..|...||   ||..:          |
Human   294 MRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNY 358

  Fly   323 DPRV---------------------------------RVLTSVEQM---PEQPSQVLTSELRIVG 351
            .|.:                                 |.:.|:.::   |..|.::..:|..|..
Human   359 GPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAV 423

  Fly   352 VRASD-------------KGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGA------ 397
            ||.:|             ....:.:.|...|......:|.::|:....:|.....|:.:
Human   424 VRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFL 488

  Fly   398 -------IGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLIS 455
                   |.:.|.||..|:.|   |.:...||..:                  .:.:.||..|:.
Human   489 QYNLIREIQSGTFDPVPNLQL---LFLNNNLLQAM------------------PSGVFSGLTLLR 532

  Fly   456 SKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRT-DIESVDGGDDVLEIKKTLLDDTVYVA 519
            ..:...|..| |..|.:::..|||: :::..:.|...| ||..:....:.|:: ..|:|:.:..|
Human   533 LNLRSNHFTS-LPVSGVLDQLKSLI-QIDLHDNPWDCTCDIVGMKLWVEQLKV-GVLVDEVICKA 594

  Fly   520 NHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSNIPDQVI 584
            .....|..:....|:......|      |...::..|..:..|||....:|:::.:.:..|..:.
Human   595 PKKFAETDMRSIKSELLCPDYS------DVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLG 653

  Fly   585 Y--GIRSPP------SL---------------------------------TSPVYTHMTPHGIYG 608
            .  |..|.|      ||                                 .|.|.:....:.:||
Human   654 AGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYG 718

  Fly   609 --------------------TKTMTAPHNGFMTLQHP----------KSRNLALIATTNSSRQHQ 643
                                .|..|...:.:..:.||          :||.      .||...::
Human   719 GGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSRE------GNSVEDYK 777

  Fly   644 HHHQLQQQQQHHHHHQQQQQ-----QQQQQQ---------------------HPLATTSPFLPAP 682
            ..|:|:.....:||.|||||     ||.|||                     .|..:.|...|..
Human   778 DLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPRE 842

  Fly   683 VVYSPA-------TGVVMKQ-------------GYMTIPRKPRAPSWAPSTSGAAGH-------G 720
            .:.||.       .|::...             .|...|..|.|.:::|:......|       |
Human   843 DLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAG 907

  Fly   721 SIQLSE--FQSPTS-----PNPSETGTATTAELQAEPVY 752
            ..:|.|  ..||.|     ||.:|. ....|:|..||.|
Human   908 DSRLREPVLYSPPSAVFVEPNRNEY-LELKAKLNVEPDY 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	26/86 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/26 (23%)
		LRR_8	99..159	CDD:290566	20/59 (34%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	9/32 (28%)
		leucine-rich repeat	197..220	CDD:275380	6/23 (26%)
		LRRCT	229..277	CDD:214507	17/58 (29%)
		Ig	296..376	CDD:143165	21/144 (15%)
SLITRK5	NP_001371538.1	leucine-rich repeat	62..79	CDD:275380	2/16 (13%)
		LRR	<72..319	CDD:227223	64/250 (26%)
		LRR 1	82..103		5/20 (25%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		LRR 2	106..127		7/23 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/25 (32%)
		LRR_8	129..189	CDD:404697	18/59 (31%)
		LRR 3	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR 4	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR 5	178..199		4/21 (19%)
		leucine-rich repeat	179..200	CDD:275380	4/21 (19%)
		LRR 6	201..222		6/20 (30%)
		leucine-rich repeat	202..226	CDD:275380	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..358		8/40 (20%)
		PPP1R42	391..>563	CDD:411060	34/194 (18%)
		LRR 7	410..431		6/20 (30%)
		LRR_8	433..493	CDD:404697	6/59 (10%)
		LRR 8	434..455		1/20 (5%)
		leucine-rich repeat	435..458	CDD:275378	2/22 (9%)
		LRR 9	458..479		3/20 (15%)
		leucine-rich repeat	459..482	CDD:275378	4/22 (18%)
		LRR 10	482..503		2/20 (10%)
		leucine-rich repeat	483..530	CDD:275378	11/67 (16%)
		LRR 11	506..527		5/41 (12%)
		LRR 12	529..550		5/21 (24%)
		leucine-rich repeat	531..554	CDD:275378	4/23 (17%)
		leucine-rich repeat	555..567	CDD:275378	2/12 (17%)
		TPKR_C2	563..>599	CDD:417692	8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..844		15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4831
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960