DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and Lingo2

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001159471.1 Gene:Lingo2 / 242384 MGIID:2442298 Length:606 Species:Mus musculus


Alignment Length:633 Identity:127/633 - (20%)
Similarity:202/633 - (31%) Gaps:231/633 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQ 84
            ||:.|||:.:     |:|   ..| ...|:.::..||..|..:.|..||:.:..|.::||.:.|:
Mouse    13 LGLAVVLLLM-----GST---IGC-PARCECSAQNKSVSCHRRRLLAIPEGIPIETKILDLSKNR 68

  Fly    85 IPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKL 149
            :..:..|||:  ..|.:.:|.|.:..|..|...||..|..|..|.|.|||::.:..|.|.||..|
Mouse    69 LKSINPEEFI--SYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNL 131

  Fly   150 RNVIINNNEIEVLPNHLFVNLSFLSRIEFRNN--------------------------------- 181
            ..:.|:.|:|.:|.:::|.:|..|..:|..:|                                 
Mouse   132 TKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEA 196

  Fly   182 ----------------------------------------------------------------- 181
                                                                             
Mouse   197 LSHLRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTNL 261

  Fly   182 ----------------------------------------------RLRQVQLHVFAGTMALSAI 200
                                                          :||.::.|.|.|...|..:
Mouse   262 STVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVL 326

  Fly   201 SLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCEL------QDFRDFAISKRLYTPPTDCQEP 259
            ::.||.|..|.:..|...:.|..||:..|...|.|.|      |....|...:.:      |..|
Mouse   327 NVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQPNLQFGGQQPM------CAGP 385

  Fly   260 PQLRGKLWSEVPSE----NFAC-RPRIL-GSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRP 318
            ..:|.:.:.:..|.    .|.| :|:|. ..::..:......:.|.|...|.|:|.::||     
Mouse   386 DTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWV----- 445

  Fly   319 LQQYDPRVRVLTSVEQMPEQPSQVL---TSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVS 380
                .||.|.:|:   .....:.||   |.|:|.  .:..|.|.|.|:|.|..|.......|.|.
Mouse   446 ----TPRRRFITT---KSNGRATVLGDGTLEIRF--AQDQDSGMYVCIASNAAGNDTFTASLTVK 501

  Fly   381 G-----------------DYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAV 428
            |                 |....||........::...||...|.|.   |.   |.|.::|...
Mouse   502 GFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMG---CF---TFLGVVLFCF 560

  Fly   429 LTLFWYCRRIKTYQKDTTMMSGDGLISSKMD-----KTHNGSMLEGSV 471
            |.||.:.|             |.|...:.:|     :.:||:::||.|
Mouse   561 LLLFVWSR-------------GKGKHKNSIDLEYVPRKNNGAVVEGEV 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 27/83 (33%)
leucine-rich repeat 76..100 CDD:275380 6/23 (26%)
LRR_8 99..159 CDD:290566 21/59 (36%)
leucine-rich repeat 101..124 CDD:275380 7/22 (32%)
LRR 122..145 CDD:197688 9/22 (41%)
leucine-rich repeat 125..148 CDD:275380 10/22 (45%)
LRR_8 148..207 CDD:290566 18/202 (9%)
leucine-rich repeat 149..172 CDD:275380 7/22 (32%)
leucine-rich repeat 173..196 CDD:275380 8/166 (5%)
LRR_8 197..>229 CDD:290566 9/31 (29%)
leucine-rich repeat 197..220 CDD:275380 6/22 (27%)
LRRCT 229..277 CDD:214507 11/57 (19%)
Ig 296..376 CDD:143165 23/82 (28%)
Lingo2NP_001159471.1 LRRNT 27..60 CDD:214470 9/33 (27%)
leucine-rich repeat 39..57 CDD:275380 6/17 (35%)
LRR 1 58..79 7/22 (32%)
leucine-rich repeat 59..82 CDD:275380 6/24 (25%)
LRR_8 60..117 CDD:404697 19/58 (33%)
LRR 2 82..103 6/20 (30%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
LRR_8 106..165 CDD:404697 20/58 (34%)
LRR 3 106..127 8/20 (40%)
leucine-rich repeat 107..130 CDD:275380 10/22 (45%)
LRR 4 130..151 6/20 (30%)
leucine-rich repeat 131..154 CDD:275380 7/22 (32%)
LRR 5 154..175 3/20 (15%)
leucine-rich repeat 155..178 CDD:275380 3/22 (14%)
PPP1R42 176..>373 CDD:411060 19/196 (10%)
LRR 6 178..199 0/20 (0%)
leucine-rich repeat 179..202 CDD:275380 0/22 (0%)
LRR 7 202..223 0/20 (0%)
leucine-rich repeat 203..250 CDD:275380 0/46 (0%)
LRR 8 226..247 0/20 (0%)
LRR 9 250..271 0/20 (0%)
leucine-rich repeat 251..274 CDD:275380 0/22 (0%)
LRR 10 274..295 0/20 (0%)
leucine-rich repeat 275..298 CDD:275380 0/22 (0%)
LRR 11 298..319 4/20 (20%)
leucine-rich repeat 299..322 CDD:275380 5/22 (23%)
LRR 12 322..343 6/20 (30%)
leucine-rich repeat 323..343 CDD:275380 6/19 (32%)
LRRCT 355..408 CDD:214507 11/58 (19%)
Ig 411..500 CDD:416386 25/102 (25%)
Ig strand A' 417..421 CDD:409353 0/3 (0%)
Ig strand B 427..436 CDD:409353 2/8 (25%)
Ig strand C 441..446 CDD:409353 2/13 (15%)
Ig strand C' 449..451 CDD:409353 0/1 (0%)
Ig strand D 460..463 CDD:409353 0/2 (0%)
Ig strand E 466..473 CDD:409353 3/8 (38%)
Ig strand F 479..487 CDD:409353 4/7 (57%)
Ig strand G 490..500 CDD:409353 2/9 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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