DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and FLRT2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001333072.1	Gene:	FLRT2 / 23768	HGNCID:	3761	Length:	660	Species:	Homo sapiens

Alignment Length:	726	Identity:	133/726 - (18%)
Similarity:	221/726 - (30%)	Gaps:	273/726 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILLLLGV---LVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQV 77
            :::.||:   :..|:|.|             ..|.|..|    ...|..::||.:|..:...:.|
Human    20 LIISLGLYSQVSKLLACP-------------SVCRCDRN----FVYCNERSLTSVPLGIPEGVTV 67

  Fly    78 LDFAHNQI------PELRR--------------EEFLLAGLP-NVHKIFLRNCTIQEVHREAFKG 121
            |...:|||      .||..              :||.: .|| ||..:.|:...||.:.|.|...
Human    68 LYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPM-NLPKNVRVLHLQENNIQTISRAALAQ 131

  Fly   122 LHILIELDLSGNRIRE--LHPGTF------------------------AGLEKLRNVIINNNEIE 160
            |..|.||.|..|.|..  :..|.|                        ..|::||   ::.|.|.
Human   132 LLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR---VDENRIA 193

  Fly   161 VLPNHLFVNLSFLSRI------------------------EF----------------------- 178
            |:.:..|.||:.|.|:                        ||
Human   194 VISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLY 258

  Fly   179 -RNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRD 242
             ::|::..:.|..|:....|..:.:..|:|..|.:..|.:|..|..|:.:.|.|.|.|.::...:
Human   259 LQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTE 323

  Fly   243 FA--ISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHD----------N 295
            :.  |...|......||.|.|:||....|:.....:| |.....:..|..|...          :
Human   324 WLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC-PTTTPGLPLFTPAPSTASPTTQPPTLS 387

  Fly   296 ISLPCRIVGSPRPNVTWVYNKRP-LQQYDPRVRVLTSVEQMPE------QPSQVLTSELRIVGVR 353
            |..|.|....|.|..    :|.| :..:|.|.||...:.:..:      ..:.:..|.|.:..|.
Human   388 IPNPSRSYTPPTPTT----SKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVM 448

  Fly   354 A----------------------------------------------SDKGAYTCVADNRGGRAE 372
            |                                              .|...|..|.|.....|.
Human   449 AYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEAT 513

  Fly   373 AEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRR 437
            .....|.:|  :...|:.:.....::|:|        ||:..||...::.:|:|.:....|:..:
Human   514 THASYLNNG--SNTASSHEQTTSHSMGSP--------FLLAGLIGGAVIFVLVVLLSVFCWHMHK 568

  Fly   438 IKTY-----------QKDTTMMSGDGLISSKMDKT---------HNGSMLEGSVIMEMQKSLLNE 482
            ...|           :||....:|....:|.::.|         :|..:|:|..          .
Human   569 KGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDF----------R 623

  Fly   483 VNPVEKPPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVD 547
            :.|:..|         :||.:..:         .::.|:.|
Human   624 LQPIYTP---------NGGINYTD---------CHIPNNMR------------------------ 646

  Fly   548 DAYANSLPPDL 558
              |.||..|||
Human   647 --YCNSSVPDL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	31/130 (24%)
		leucine-rich repeat	76..100	CDD:275380	11/44 (25%)
		LRR_8	99..159	CDD:290566	21/86 (24%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR	122..145	CDD:197688	9/48 (19%)
		leucine-rich repeat	125..148	CDD:275380	9/48 (19%)
		LRR_8	148..207	CDD:290566	17/106 (16%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	7/70 (10%)
		LRR_8	197..>229	CDD:290566	8/31 (26%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	13/49 (27%)
		Ig	296..376	CDD:143165	20/132 (15%)
FLRT2	NP_001333072.1	LRRNT	35..66	CDD:214470	9/47 (19%)
		NEL	<54..>265	CDD:330839	44/214 (21%)
		LRR 1	64..85		6/20 (30%)
		leucine-rich repeat	65..86	CDD:275378	7/20 (35%)
		LRR 2	89..109		3/20 (15%)
		leucine-rich repeat	90..110	CDD:275380	4/20 (20%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR 4	134..155		7/20 (35%)
		leucine-rich repeat	135..160	CDD:275380	8/24 (33%)
		LRR 5	160..181		0/20 (0%)
		leucine-rich repeat	161..181	CDD:275380	0/19 (0%)
		leucine-rich repeat	182..205	CDD:275380	9/25 (36%)
		LRR 6	182..202		7/22 (32%)
		LRR 7	205..225		2/19 (11%)
		leucine-rich repeat	206..231	CDD:275380	2/24 (8%)
		LRR 8	231..252		2/20 (10%)
		leucine-rich repeat	232..253	CDD:275380	2/20 (10%)
		LRR_8	252..311	CDD:316378	11/58 (19%)
		LRR 9	253..274		3/20 (15%)
		leucine-rich repeat	254..277	CDD:275380	3/22 (14%)
		LRR 10	277..298		5/20 (25%)
		leucine-rich repeat	278..301	CDD:275380	6/22 (27%)
		PCC	282..>359	CDD:188093	20/76 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413		8/43 (19%)
		fn3	426..494	CDD:306538	4/67 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000