DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and Lingo3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001013780.2	Gene:	Lingo3 / 237403	MGIID:	3609246	Length:	589	Species:	Mus musculus

Alignment Length:	582	Identity:	126/582 - (21%)
Similarity:	191/582 - (32%)	Gaps:	197/582 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFA 81
            |.:||:.::|:...|..||       | ...|:.::..::..|..:.||.||:.:..|.::|:.:
Mouse     5 LHMLGLHLLLLPTAPLAAG-------C-PARCECSASTRTVACGRRRLTAIPEGIPAETRMLELS 61

  Fly    82 HNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGL 146
            .|:|..|...:  ||.||.:.::.|.:..|..|...||..|..|..|.|.||:::.:.||.|..|
Mouse    62 RNRIRCLNPGD--LASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHL 124

  Fly   147 EKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQ------- 204
            :.|..:.::.|::.:|.:..|.:|..|.|:|..:|.|..:....|||.:.|:.::||:
Mouse   125 DSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLS 189

  Fly   205 ----------------------------------------------------------------- 204

Mouse   190 PESLGHLRGLGALRLRHLAIAALEDQNFQKLPGLSHLEIDNWPLLEEVAPGSLRGLNLTSLSITH 254

  Fly   205 ----------------------------------------------------------------- 204

Mouse   255 TNITAVPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQI 319

  Fly   205 -------NRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD-----CQ 257
                   |.||.|.:.||..:..|..|.:.||...|.|.|     ..|.:|..|...|     |.
Mouse   320 RLLNLSDNLLSTLEENTFHSVNTLETLRVDGNPLACDCRL-----LWIVQRRKTLNFDGRLPACA 379

  Fly   258 EPPQLRGKLWSEVPS----ENFACR-PRILGSVRSFIEANH-DNISLPCRIVGSPRPNVTWVYNK 316
            .|.::||.....:|.    |.|.|| |:|.......:.|.. |::...||..|.|.|.|.||
Mouse   380 TPAEVRGDALHNLPDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWV--- 441

  Fly   317 RPLQQYDP-------RVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAE 374
              ..|:..       |.|||         |...||    |...|..|.|.|||||.|.||. :..
Mouse   442 --TPQHHSVTAASRGRARVL---------PGGTLT----IADTRPQDSGTYTCVASNAGGN-DTY 490

  Fly   375 FQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCR 436
            |..|.....|.. :..||.....:|.......|.:.:...:...|.|.::|...|.||.:.|
Mouse   491 FATLTVQPAANR-TQGDGHNETQVGVRFPLDLTTILVSTAMGCITFLGVVLFCFLLLFVWSR 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	17/202 (8%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	197..>229	CDD:290566	11/175 (6%)
		leucine-rich repeat	197..220	CDD:275380	9/166 (5%)
		LRRCT	229..277	CDD:214507	15/56 (27%)
		Ig	296..376	CDD:143165	28/86 (33%)
Lingo3	NP_001013780.2	LRRNT	23..55	CDD:214470	8/39 (21%)
		leucine-rich repeat	34..53	CDD:275380	5/18 (28%)
		LRR 1	54..75		6/22 (27%)
		LRR	<55..353	CDD:227223	49/299 (16%)
		leucine-rich repeat	55..78	CDD:275380	7/24 (29%)
		LRR 2	78..99		5/20 (25%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		LRR 3	102..123		8/20 (40%)
		leucine-rich repeat	103..150	CDD:275380	14/46 (30%)
		LRR 4	126..147		4/20 (20%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		LRR 6	174..195		3/20 (15%)
		leucine-rich repeat	175..198	CDD:275380	3/22 (14%)
		leucine-rich repeat	199..222	CDD:275380	0/22 (0%)
		LRR 7	206..227		0/20 (0%)
		leucine-rich repeat	223..246	CDD:275380	0/22 (0%)
		LRR_8	246..302	CDD:338972	0/55 (0%)
		LRR 8	246..267		0/20 (0%)
		leucine-rich repeat	247..270	CDD:275380	0/22 (0%)
		LRR 9	270..291		0/20 (0%)
		leucine-rich repeat	271..292	CDD:275380	0/20 (0%)
		LRR 10	294..315		0/20 (0%)
		leucine-rich repeat	295..318	CDD:275380	0/22 (0%)
		LRR 11	318..339		6/20 (30%)
		leucine-rich repeat	321..342	CDD:275380	6/20 (30%)
		PCC	331..>405	CDD:188093	22/78 (28%)
		I-set	406..496	CDD:369462	34/108 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910