DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lingo1

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_006511149.1	Gene:	Lingo1 / 235402	MGIID:	1915522	Length:	647	Species:	Mus musculus

Alignment Length:	596	Identity:	121/596 - (20%)
Similarity:	193/596 - (32%)	Gaps:	216/596 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMA--LPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQV 77
            ::||:||.::...|  .||               .|:.::..::..|..|....:|:.:..|.::
Mouse    53 ILLLVLGSVLSGSATGCPP---------------RCECSAQDRAVLCHRKRFVAVPEGIPTETRL 102

  Fly    78 LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGT 142
            ||...|:|..|.::||  |..|::.::.|....:..|...||..|..|..|.|..||::.:..|.
Mouse   103 LDLGKNRIKTLNQDEF--ASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGV 165

  Fly   143 FAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQ--- 204
            |.||..|..:.|:.|:|.:|.:::|.:|..|..:|..:|.|..:....|:|..:|..::||:
Mouse   166 FTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNL 230

  Fly   205 -----NRLSHLH----------------KETFKDLQKL--------------------------- 221
                 ..|||||                ..:||.|.:|
Mouse   231 TSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSL 295

  Fly   222 --------------------------------------MH------------------------- 223
                                                  :|
Mouse   296 SITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRG 360

  Fly   224 ------------------------------LSLQGNAWNCSCELQDFRDFAISKRLY------TP 252
                                          |.|..|...|.|.|     ..:.:|.:      ..
Mouse   361 LNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRL-----LWVFRRRWRLNFNRQQ 420

  Fly   253 PTDCQEPPQLRGKLWSEVPS----ENFACRP---RILGSVRSFIEANHDNISLPCRIVGSPRPNV 310
            || |..|..::||.:.:.|.    ..|.||.   |...:.:.|::..| .:...||..|.|.|.:
Mouse   421 PT-CATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGH-TVQFVCRADGDPPPAI 483

  Fly   311 TWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEF 375
            .|:..::.|.......|:..    .|:.     |.|:|...|:  |.|.|.|:|.|.||......
Mouse   484 LWLSPRKHLVSAKSNGRLTV----FPDG-----TLEVRYAQVQ--DNGTYLCIAANAGGNDSMPA 537

  Fly   376 QLLV---SGDYA-------GAVSASDGMGMGAIGAPTID-PQTNMFLIICLIITTLL-------L 422
            .|.|   |.|:.       ..:|...|.|.......|:. |    |.|..|||.|.:       :
Mouse   538 HLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFP----FDIKTLIIATTMGFISFLGV 598

  Fly   423 LLLVAVLTLFW 433
            :|...||...|
Mouse   599 VLFCLVLLFLW 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	26/83 (31%)
		leucine-rich repeat	76..100	CDD:275380	8/23 (35%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	16/66 (24%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	15/175 (9%)
		leucine-rich repeat	197..220	CDD:275380	11/46 (24%)
		LRRCT	229..277	CDD:214507	13/57 (23%)
		Ig	296..376	CDD:143165	21/79 (27%)
Lingo1	XP_006511149.1	LRRNT	68..102	CDD:214470	7/48 (15%)
		LRR	<93..398	CDD:227223	54/306 (18%)
		leucine-rich repeat	100..123	CDD:275380	8/24 (33%)
		leucine-rich repeat	124..147	CDD:275380	5/22 (23%)
		LRR_8	147..206	CDD:338972	19/58 (33%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		leucine-rich repeat	172..219	CDD:275380	13/46 (28%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..291	CDD:275380	4/46 (9%)
		leucine-rich repeat	292..315	CDD:275380	0/22 (0%)
		leucine-rich repeat	316..339	CDD:275380	1/22 (5%)
		leucine-rich repeat	340..363	CDD:275380	0/22 (0%)
		leucine-rich repeat	364..384	CDD:275380	0/19 (0%)
		PCC	368..>448	CDD:188093	15/85 (18%)
		Ig	466..541	CDD:386229	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000