DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and SLITRK3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001305739.1	Gene:	SLITRK3 / 22865	HGNCID:	23501	Length:	977	Species:	Homo sapiens

Alignment Length:	1046	Identity:	195/1046 - (18%)
Similarity:	325/1046 - (31%)	Gaps:	365/1046 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRRLGMILLLLGVLVVLMALPPPTAGTTDWM-QSC-GTCHCQWNSGKKSADCKNKALTKIPQ--D 70
            ||.|.:|  ||..:.:....|.|....::.: :.| ..|:|:.........|.:|..|.|.|  :
Human    12 GRMLWII--LLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74

  Fly    71 MSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNR- 134
            ..:....|....|.:.:|....||  .|.|...|.|.|..:|::...||.||.||..|.|..|:
Human    75 FWSRPFKLYLQRNSMRKLYTNSFL--HLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKL 137

  Fly   135 -----------------------IRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRI 176
                                   |:.:..|.|..|.|||.:|:|:|.|.:||.:||..:| |:.:
Human   138 DVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVS-LTHL 201

  Fly   177 EFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFR 241
            :.|.|||:               :...:..|.|:.:       .||.|.|:.|.|||:||:...:
Human   202 DLRGNRLK---------------VLFYRGMLDHIGR-------SLMELQLEENPWNCTCEIVQLK 244

  Fly   242 DFAISKRLYTP---PTDCQEPPQLRGK----------------------------------LWSE 269
            .: :.:..||.   ...|:.|....||                                  .|..
Human   245 SW-LERIPYTALVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPT 308

  Fly   270 VPSENFACRPRILGSVR---SFIEANHDNIS-LPCRIVGSPRPNVT--WVY---NKRPLQQYDPR 325
            .||.       :|.||.   |.:|....|.. .|.:...:|||..|  .:|   |:.|:..|..|
Human   309 KPSS-------MLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTR 366

  Fly   326 VRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEF--------QLLVSGD 382
                        .|..::........:..:|.| .|.....||....:|.        :|.:|.:
Human   367 ------------PPIPIICPTGCTCNLHINDLG-LTVNCKERGFNNISELLPRPLNAKKLYLSSN 418

  Fly   383 YAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTM 447
            ....:..||                                        ||.
Human   419 LIQKIYRSD----------------------------------------FWN------------- 430

  Fly   448 MSGDGLISSKMDKTHNGS-----MLEGSVI-MEMQKSLLNEVNPVEK--PPRRTDIESVDGGDDV 504
                   .|.:|..|.|:     :.:|:.| :...|||....|.:||  |.....::|
Human   431 -------FSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQS------- 481

  Fly   505 LEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPARVPPTS 569
                   |....:..|..|:.:..:.::     .|..:..::::....:||.|..|      .||
Human   482 -------LHYLYFEFNVIREIQPAAFSL-----MPNLKLLFLNNNLLRTLPTDAFA------GTS 528

  Fly   570 PSMQSSQSN----IPDQVIYGI-------------RSPPSLTSPVYTH------MTPHGIYGTKT 611
            .:..:.:.|    :|   :.|:             .:|...|..:...      ::...:.|...
Human   529 LARLNLRKNYFLYLP---VAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVL 590

  Fly   612 MTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTS 676
            ..:|.|    |.|...|.:.|              ::...:..|.....:...|....|.:.  :
Human   591 CRSPEN----LTHRDVRTIEL--------------EVLCPEMLHVAPAGESPAQPGDSHLIG--A 635

  Fly   677 PFLPAPVVYSPATG------------------VVMKQG---YMTIPRKPRAPSWAPSTSGAAGHG 720
            |...:|..:||..|                  |.:..|   |:...|:.:.|
Human   636 PTSASPYEFSPPGGPVPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKKLP------------- 687

  Fly   721 SIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQGGAGQQYSM 785
                  |:|........||    .::|...::::.|     ||         .|..||.|:
Human   688 ------FRSKRQEGVDLTG----IQMQCHRLFEDGG-----GG---------GGGSGGGGR---- 724

  Fly   786 RDRPLPATPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQQQQQQRLGSMDTEPLYGVR-QQGI 849
                    |:|:|...|.....:||.|...:.|                 |...|:|..| ::.:
Human   725 --------PTLSSPEKAPPVGHVYEYIPHPVTQ-----------------MCNNPIYKPREEEEV 764

  Fly   850 TILPGSSISGAGLGHAAYLSPGSGAAVSPSHASSSGDSPKAAKIPPRPPPKPKKKMSVTTTRSGQ 914
            .:........|..|......||.|.|:..|  ....::||......|...:.:|:.::..
Human   765 AVSSAQEAGSAERGGPGTQPPGMGEALLGS--EQFAETPKENHSNYRTLLEKEKEWALAV----- 822

  Fly   915 GSTSQL 920
             |:|||
Human   823 -SSSQL 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/107 (28%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	24/83 (29%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR	122..145	CDD:197688	9/46 (20%)
		leucine-rich repeat	125..148	CDD:275380	8/46 (17%)
		LRR_8	148..207	CDD:290566	17/58 (29%)
		leucine-rich repeat	149..172	CDD:275380	10/22 (45%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	6/31 (19%)
		leucine-rich repeat	197..220	CDD:275380	2/22 (9%)
		LRRCT	229..277	CDD:214507	15/84 (18%)
		Ig	296..376	CDD:143165	17/93 (18%)
SLITRK3	NP_001305739.1	leucine-rich repeat	81..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR_8	105..161	CDD:316378	13/55 (24%)
		leucine-rich repeat	127..150	CDD:275380	4/22 (18%)
		LRR_8	150..208	CDD:316378	19/58 (33%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		leucine-rich repeat	175..197	CDD:275380	10/21 (48%)
		leucine-rich repeat	198..402	CDD:275380	48/246 (20%)
		leucine-rich repeat	224..271	CDD:275380	15/47 (32%)
		LRRCT	232..>270	CDD:214507	10/38 (26%)
		leucine-rich repeat	272..410	CDD:275380	26/157 (17%)
		leucine-rich repeat	403..433	CDD:275380	6/89 (7%)
		LRR_8	432..492	CDD:316378	16/73 (22%)
		leucine-rich repeat	434..457	CDD:275380	5/22 (23%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..501	CDD:275380	3/18 (17%)
		leucine-rich repeat	506..528	CDD:275380	4/27 (15%)
		leucine-rich repeat	529..553	CDD:275380	3/26 (12%)
		LRRCT	562..>597	CDD:214507	5/38 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4831
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960