DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and iglr-3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001293349.1	Gene:	iglr-3 / 171771	WormBaseID:	WBGene00021353	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	94/383 - (24%)
Similarity:	149/383 - (38%)	Gaps:	69/383 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RRLGMILLLLGVLVVLMALPPPTAGTTDWMQSCG----TCHCQWNSGKKSADCKNKALTKIPQDM 71
            |...::||.|.::                  ||.    ||...|.|.:.|.||.:..|.:.||.:
Worm     2 REAALLLLFLPII------------------SCSNAPKTCKSFWISNRPSQDCASLTLQEPPQLL 48

  Fly    72 SNEMQVLDFAHNQIPELRREEFLLAGLPNVHK----IFLRNCTIQEVHREAFKGLHILIELDLSG 132
            .|.:. |..::|.|       |.:...|:.::    :.|..|.::::..:|......|.|||:|.
Worm    49 PNVLS-LSLSNNSI-------FRITTFPSEYRRLQSLRLDQCQLEKLDFDALSVFEQLRELDVSR 105

  Fly   133 NRIREL-HPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMA 196
            |.:.:| .|...|.|..|.   :..|....:|:  ..:|..|..::..:|||..|:..:.  ...
Worm   106 NSLSKLIIPRNLASLRVLN---LAFNAFTYVPD--MSHLESLRLVDLSHNRLISVRPRML--PFN 163

  Fly   197 LSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLY-TPPTDCQEPP 260
            |..:.|..||..||....|  |.||..|.:..|...|.|.|..|..:|....|: :....|:.|.
Worm   164 LEVVRLAANRFQHLSPWPF--LHKLQELDVTFNDLECDCSLWHFVTWAEKLALFDSTMLPCRRPS 226

  Fly   261 QLR-----GKLWSEVPSENFACRPRIL-GSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPL 319
            :||     ||.         .|.|.:: .|..|.:.:..|...:.|..:.:|.|.:.|.:|.:
Worm   227 ELRKSPIDGKT---------VCGPTVVTSSPESAVVSLDDAHVMCCTALATPSPQLYWQFNGK-- 280

  Fly   320 QQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQL 377
                   .:.:.:.|.....|..|...|.|..||..|.|.|.|||...|..:..||.:
Worm   281 -------NISSGLSQKHLSESGKLEFCLEIPKVRLKDMGKYKCVASLAGLNSSKEFHV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	20/88 (23%)
		leucine-rich repeat	76..100	CDD:275380	4/23 (17%)
		LRR_8	99..159	CDD:290566	16/64 (25%)
		leucine-rich repeat	101..124	CDD:275380	3/26 (12%)
		LRR	122..145	CDD:197688	8/23 (35%)
		leucine-rich repeat	125..148	CDD:275380	10/23 (43%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	13/53 (25%)
		Ig	296..376	CDD:143165	20/79 (25%)
iglr-3	NP_001293349.1	LRR	<47..>196	CDD:227223	40/165 (24%)
		leucine-rich repeat	51..73	CDD:275380	5/29 (17%)
		leucine-rich repeat	74..97	CDD:275380	3/22 (14%)
		leucine-rich repeat	98..119	CDD:275380	8/20 (40%)
		leucine-rich repeat	120..141	CDD:275380	5/25 (20%)
		leucine-rich repeat	142..163	CDD:275380	5/22 (23%)
		leucine-rich repeat	164..185	CDD:275380	8/22 (36%)
		Ig_3	243..319	CDD:372822	20/84 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	66	1.000	Inparanoid score	I3947
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.920