DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and Igfals

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus

Alignment Length:	303	Identity:	75/303 - (24%)
Similarity:	108/303 - (35%)	Gaps:	125/303 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGT 142
            ||.:||::..|..:.|  .||..:|.:.|.:..|..:....||.||.|.||.|..||||:|...|
Mouse   306 LDLSHNRVAGLLEDTF--PGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKT 368

  Fly   143 FAGLEKLRNVIINNNEI-EV-----------------------LPNHLFVNLSFLSRIEFRNNRL 183
            |.||.:|..:.:|:|:| ||                       ||.|:|..|..|..:...::.|
Mouse   369 FEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCL 433

  Fly   184 RQVQLHVFAGTMAL--------SAISLEQ----------------NRLSHLHKETFKDLQKLMHL 224
            .:::||.|||...|        |..|:|:                |:|:||.::.|:.|.:|.:|
Mouse   434 GRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYL 498

  Fly   225 -----------------------------------------------------SLQ--------- 227
                                                                 |||
Mouse   499 LLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVPQPGLE 563

  Fly   228 -----GNAWNCSCELQDFRDFAISKRLYTP--------PTDCQ 257
                 .|.|:|||.|:..||||:......|        ..|||
Mouse   564 RLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCEGDDCQ 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	32/82 (39%)
		leucine-rich repeat	76..100	CDD:275380	8/21 (38%)
		LRR_8	99..159	CDD:290566	23/59 (39%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	13/22 (59%)
		leucine-rich repeat	125..148	CDD:275380	13/22 (59%)
		LRR_8	148..207	CDD:290566	23/106 (22%)
		leucine-rich repeat	149..172	CDD:275380	11/46 (24%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	197..>229	CDD:290566	15/122 (12%)
		leucine-rich repeat	197..220	CDD:275380	10/46 (22%)
		LRRCT	229..277	CDD:214507	14/37 (38%)
		Ig	296..376	CDD:143165
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470
		leucine-rich repeat	92..110	CDD:275380
		PLN00113	96..>558	CDD:331614	61/253 (24%)
		leucine-rich repeat	114..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380
		leucine-rich repeat	159..182	CDD:275380
		leucine-rich repeat	183..206	CDD:275380
		leucine-rich repeat	207..230	CDD:275380
		leucine-rich repeat	231..254	CDD:275380
		leucine-rich repeat	255..278	CDD:275380
		leucine-rich repeat	279..302	CDD:275380
		leucine-rich repeat	303..326	CDD:275380	8/21 (38%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..374	CDD:275380	13/22 (59%)
		leucine-rich repeat	375..396	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..446	CDD:275380	7/22 (32%)
		leucine-rich repeat	447..470	CDD:275380	4/22 (18%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		leucine-rich repeat	495..516	CDD:275380	2/20 (10%)
		leucine-rich repeat	519..542	CDD:275380	0/22 (0%)
		leucine-rich repeat	543..561	CDD:275380	3/17 (18%)
		TPKR_C2	570..613	CDD:326558	14/37 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12130
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000