DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and LINGO2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001245211.1	Gene:	LINGO2 / 158038	HGNCID:	21207	Length:	606	Species:	Homo sapiens

Alignment Length:	636	Identity:	138/636 - (21%)
Similarity:	212/636 - (33%)	Gaps:	237/636 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LGVLVVLMALPPPTAGTTDWMQSCGTC--HCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAH 82
            ||:.|||:           :|.|...|  .|:.::..||..|..:.|..||:.:..|.::||.:.
Human    13 LGLAVVLI-----------FMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSK 66

  Fly    83 NQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLE 147
            |::..:..|||:  ..|.:.:|.|.:..|..|...||..|..|..|.|.|||::.:..|.|.||.
Human    67 NRLKSVNPEEFI--SYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLS 129

  Fly   148 KLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQ-------- 204
            .|..:.|:.|:|.:|.:::|.:|..|..:|..:|.|..:....|:|.::|..::||:
Human   130 NLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPT 194

  Fly   205 ---------------------------NRLSHL-HKE---------------------------- 213
                                       .||.|| |.|
Human   195 EALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNT 259

  Fly   214 --------TFKDLQKLMHLSL-------------------------------------QG----- 228
                    .||.|..|.||:|                                     ||
Human   260 NLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLR 324

  Fly   229 ------------------------------NAWNCSCEL------QDFRDFAISKRLYTPPTDCQ 257
                                          |...|.|.|      |....|...:.:      |.
Human   325 VLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPM------CA 383

  Fly   258 EPPQLRGKLWSEVPSE----NFAC-RPRIL-GSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNK 316
            .|..:|.:.:.:..|.    .|.| :|:|. ..::..:......:.|.|...|.|:|.::||
Human   384 GPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWV--- 445

  Fly   317 RPLQQYDPRVRVLTSVEQMPEQPSQVL---TSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLL 378
                  .||.|.:|:   .....:.||   |.|:|.  .:..|.|.|.|:|.|..|.......|.
Human   446 ------TPRRRFITT---KSNGRATVLGDGTLEIRF--AQDQDSGMYVCIASNAAGNDTFTASLT 499

  Fly   379 VSGDYAGAVSASDGMGMGAIGAP--------TIDPQTN-----MFLIICLIIT-----TLLLLLL 425
            |.|      .|||.. :.|...|        ||...||     :.|...|:.|     |.|.::|
Human   500 VKG------FASDRF-LYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVL 557

  Fly   426 VAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMD-----KTHNGSMLEGSV 471
            ...|.||.:.|             |.|...:.:|     :.:||:::||.|
Human   558 FCFLLLFVWSR-------------GKGKHKNSIDLEYVPRKNNGAVVEGEV 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	27/83 (33%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	21/59 (36%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	16/93 (17%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	18/175 (10%)
		leucine-rich repeat	197..220	CDD:275380	12/94 (13%)
		LRRCT	229..277	CDD:214507	11/57 (19%)
		Ig	296..376	CDD:143165	23/82 (28%)
LINGO2	NP_001245211.1	LRRNT	27..60	CDD:214470	9/32 (28%)
		leucine-rich repeat	39..57	CDD:275380	6/17 (35%)
		LRR 1	58..79		7/22 (32%)
		leucine-rich repeat	59..82	CDD:275380	6/24 (25%)
		LRR_8	60..117	CDD:316378	19/58 (33%)
		LRR 2	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR_8	106..165	CDD:316378	20/58 (34%)
		LRR 3	106..127		8/20 (40%)
		leucine-rich repeat	107..130	CDD:275380	10/22 (45%)
		LRR 4	130..151		6/20 (30%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_5	146..276	CDD:331043	20/129 (16%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR 6	178..199		3/20 (15%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR 7	202..223		0/20 (0%)
		leucine-rich repeat	203..250	CDD:275380	6/46 (13%)
		LRR 8	226..247		4/20 (20%)
		LRR_8	250..309	CDD:316378	7/58 (12%)
		LRR 9	250..271		1/20 (5%)
		leucine-rich repeat	251..274	CDD:275380	3/22 (14%)
		LRR 10	274..295		4/20 (20%)
		leucine-rich repeat	275..298	CDD:275380	4/22 (18%)
		LRR_8	298..357	CDD:316378	3/58 (5%)
		LRR 11	298..319		0/20 (0%)
		leucine-rich repeat	299..322	CDD:275380	2/22 (9%)
		LRR 12	322..343		0/20 (0%)
		leucine-rich repeat	323..343	CDD:275380	0/19 (0%)
		PCC	327..>391	CDD:188093	9/69 (13%)
		I-set	410..500	CDD:254352	26/103 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910