DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and RTN4RL1

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_848663.1 Gene:RTN4RL1 / 146760 HGNCID:21329 Length:441 Species:Homo sapiens


Alignment Length:386 Identity:88/386 - (22%)
Similarity:146/386 - (37%) Gaps:85/386 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQI 85
            :|::|:|...|..|      .| ..|.|.  ....:..|:......||:.:..:.:.:...:|:|
Human    10 LLLLLVAAELPLGG------GCPRDCVCY--PAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRI 66

  Fly    86 PELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNR-IRELHP--------- 140
            ..|:...|    .|.:..:::.:..|..:|...|:|...|.||||..|| :|.|.|         
Human    67 GLLQPGHF----SPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127

  Fly   141 ---------------GTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHV 190
                           |.|.||..|:.:.:.:|.||.|.:.:||:|..||.:....|:|..:....
Human   128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGT 192

  Fly   191 FAGTMALSAISLEQNRLSHLHKETFKDLQKLM------------------------HLSLQGNAW 231
            |.|.:.|..:.|.:|:|..:|.:.|.||::|.                        .|.|.||.|
Human   193 FRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPW 257

  Fly   232 NCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFA-C---------RPRILGSVR 286
            :|.|..:...::....|..:....|..|....|:....:.:|:|. |         :...|.:..
Human   258 DCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTD 322

  Fly   287 SFIEANHDNISLPCRIVG---SPRPNVTWVYNKRPLQQ-YDPRVRVLTSV----EQMPEQP 339
            ......|.:...|.|..|   .|||.     :::|.:. .:||.|...|.    :|.||.|
Human   323 RAARKEHHSPHGPTRSKGHPHGPRPG-----HRKPGKNCTNPRNRNQISKAGAGKQAPELP 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 25/108 (23%)
leucine-rich repeat 76..100 CDD:275380 4/23 (17%)
LRR_8 99..159 CDD:290566 21/84 (25%)
leucine-rich repeat 101..124 CDD:275380 4/22 (18%)
LRR 122..145 CDD:197688 12/47 (26%)
leucine-rich repeat 125..148 CDD:275380 14/47 (30%)
LRR_8 148..207 CDD:290566 17/58 (29%)
leucine-rich repeat 149..172 CDD:275380 8/22 (36%)
leucine-rich repeat 173..196 CDD:275380 6/22 (27%)
LRR_8 197..>229 CDD:290566 11/55 (20%)
leucine-rich repeat 197..220 CDD:275380 8/22 (36%)
LRRCT 229..277 CDD:214507 10/48 (21%)
Ig 296..376 CDD:143165 15/52 (29%)
RTN4RL1NP_848663.1 leucine-rich repeat 37..54 CDD:275380 3/16 (19%)
LRR 1 55..76 4/24 (17%)
LRR_8 57..111 CDD:316378 14/57 (25%)
leucine-rich repeat 57..77 CDD:275380 4/23 (17%)
LRR 2 77..98 3/20 (15%)
leucine-rich repeat 78..101 CDD:275380 4/22 (18%)
LRR 3 101..123 10/21 (48%)
leucine-rich repeat 102..126 CDD:275380 10/23 (43%)
LRR_8 126..185 CDD:316378 15/58 (26%)
LRR 4 126..147 2/20 (10%)
leucine-rich repeat 127..150 CDD:275380 4/22 (18%)
LRR 5 150..171 6/20 (30%)
leucine-rich repeat 151..174 CDD:275380 8/22 (36%)
LRR_8 174..233 CDD:316378 15/58 (26%)
LRR 6 174..195 5/20 (25%)
leucine-rich repeat 175..198 CDD:275380 6/22 (27%)
LRR 7 198..219 6/20 (30%)
leucine-rich repeat 199..222 CDD:275380 8/22 (36%)
LRR 8 222..243 1/20 (5%)
leucine-rich repeat 223..246 CDD:275380 1/22 (5%)
TPKR_C2 255..300 CDD:326558 8/44 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..382 18/80 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..417
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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