DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and SLITRK4

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001171678.1	Gene:	SLITRK4 / 139065	HGNCID:	23502	Length:	837	Species:	Homo sapiens

Alignment Length:	647	Identity:	129/647 - (19%)
Similarity:	211/647 - (32%)	Gaps:	249/647 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SGRRLGMILLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGK--KSADCKNKALTK----I 67
            |.|.|..|:.....:..|...|.|             |.|:.:...  .|.:|:.|.:..    |
Human   322 SNRNLSQIVSYQTRVPPLTPCPAP-------------CFCKTHPSDLGLSVNCQEKNIQSMSELI 373

  Fly    68 PQ-----------------DMSN--EMQVLDFAH---NQIPELRREEFLLAGLPNVHKIFLRNCT 110
            |:                 |:|:  :.:.||..|   |||..::.:.|  ..|.|:.:::|....
Human   374 PKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVF--HNLTNLRRLYLNGNQ 436

  Fly   111 IQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSR 175
            |:.::.|.|.|||.|..|.|..|.|:|:..|||..:..|:.:.:|||.::.||.::|.... |:|
Human   437 IERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAP-LAR 500

  Fly   176 IEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCEL--- 237
            :..|||:...         :.:|.: |:|             ||.|..:.|:||.|:|:|:|
Human   501 LNLRNNKFMY---------LPVSGV-LDQ-------------LQSLTQIDLEGNPWDCTCDLVAL 542

  Fly   238 ----QDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISL 298
                :...|..:.|.|     .|:.|.|........:.:| ..| |::|..
Human   543 KLWVEKLSDGIVVKEL-----KCETPVQFANIELKSLKNE-ILC-PKLLNK-------------- 586

  Fly   299 PCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCV 363
            |.....||.|.:|:.   .||
Human   587 PSAPFTSPAPAITFT---TPL-------------------------------------------- 604

  Fly   364 ADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAV 428
                                            |.|.:|...| ..:.::|..|:..|:|.:.||.
Human   605 --------------------------------GPIRSPPGGP-VPLSILILSILVVLILTVFVAF 636

  Fly   429 LTLFWYCRRIKTYQKDTTMMSG-----------------------DGLIS--------SKMDKTH 462
            ..|.:..||.|   |.|....|                       |||.:        .:|.|:|
Human   637 CLLVFVLRRNK---KPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSH 698

  Fly   463 NGSMLE---GSVIMEM--QKSLLNEVNPVEKPPRRTD----IESVDGGDDVLEIKKTLLDDTVYV 518
            ...:.|   |.:..:.  ||.::..|...||.....|    :.::|..|::...:    |..|::
Human   699 TCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSR----DSNVFI 759

  Fly   519 ANH-SRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSNI 579
            .|. ...:|..|:.:|                          .|..|.|...|..:|.:|.|
Human   760 QNFLESKKEYNSIGVS--------------------------GFEIRYPEKQPDKKSKKSLI 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	29/86 (34%)
		leucine-rich repeat	76..100	CDD:275380	8/26 (31%)
		LRR_8	99..159	CDD:290566	21/59 (36%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	11/22 (50%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	15/58 (26%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	7/31 (23%)
		leucine-rich repeat	197..220	CDD:275380	4/22 (18%)
		LRRCT	229..277	CDD:214507	12/54 (22%)
		Ig	296..376	CDD:143165	7/79 (9%)
SLITRK4	NP_001171678.1	LRR 1	60..81
		leucine-rich repeat	63..84	CDD:275380
		LRR_8	83..143	CDD:316378
		LRR 2	84..105
		leucine-rich repeat	85..108	CDD:275380
		LRR 3	108..129
		leucine-rich repeat	109..132	CDD:275380
		LRR_8	132..190	CDD:316378
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275380
		LRR 5	156..177
		leucine-rich repeat	157..179	CDD:275380
		LRR 6	179..200
		leucine-rich repeat	180..204	CDD:275380
		leucine-rich repeat	205..295	CDD:275380
		LRRCT	213..>253	CDD:214507
		leucine-rich repeat	296..371	CDD:275380	12/61 (20%)
		leucine-rich repeat	372..402	CDD:275380	4/29 (14%)
		LRR 7	378..399		2/20 (10%)
		LRR_8	402..461	CDD:316378	20/60 (33%)
		LRR 8	402..423		7/22 (32%)
		leucine-rich repeat	403..426	CDD:275380	8/24 (33%)
		LRR 9	426..447		5/20 (25%)
		leucine-rich repeat	427..450	CDD:275380	6/22 (27%)
		LRR 10	450..471		9/20 (45%)
		leucine-rich repeat	451..472	CDD:275380	9/20 (45%)
		LRR 11	474..495		7/20 (35%)
		leucine-rich repeat	475..496	CDD:275380	7/20 (35%)
		LRR 12	497..518		6/31 (19%)
		leucine-rich repeat	498..522	CDD:275380	9/46 (20%)
		PCC	502..>563	CDD:188093	20/88 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4831
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960