DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek5 and CPN2

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001073982.3 Gene:CPN2 / 1370 HGNCID:2313 Length:545 Species:Homo sapiens


Alignment Length:342 Identity:80/342 - (23%)
Similarity:130/342 - (38%) Gaps:106/342 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLLGVLV----VLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDM---SNE 74
            |..||.|.    :|.|||   .|....:.:..:.|.|.|.           |..:|:.:   ...
Human   120 LTSLGKLTLNFNMLEALP---EGLFQHLAALESLHLQGNQ-----------LQALPRRLFQPLTH 170

  Fly    75 MQVLDFAHNQIPELRREEF--------------LLAGLP--------NVHKIFLRNCTIQEVHRE 117
            ::.|:.|.|.:.:|..|.|              .|:|||        ::.::||.:..|.|:..:
Human   171 LKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQ 235

  Fly   118 AFKGL--------------HI----------------------------------LIELDLSGNR 134
            .|..|              |:                                  |:.|.|:.|:
Human   236 VFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300

  Fly   135 IRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSA 199
            :..:..||||.|..||:::::.|.|..||..:|.:|..|.::...:|.|..:...:|.....|..
Human   301 LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLEL 365

  Fly   200 ISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCE-------LQDFRDFAISKRLYTPPTDCQ 257
            :||.:|:|:.|.:..|.....|.:|:|.||.|.|.|.       ||.:.|     ||....|.|.
Human   366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTD-----RLLNIQTYCA 425

  Fly   258 EPPQLRGKLWSEVPSEN 274
            .|..|:|::   ||:.|
Human   426 GPAYLKGQV---VPALN 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 29/153 (19%)
leucine-rich repeat 76..100 CDD:275380 10/45 (22%)
LRR_8 99..159 CDD:290566 20/115 (17%)
leucine-rich repeat 101..124 CDD:275380 6/36 (17%)
LRR 122..145 CDD:197688 9/70 (13%)
leucine-rich repeat 125..148 CDD:275380 9/22 (41%)
LRR_8 148..207 CDD:290566 16/58 (28%)
leucine-rich repeat 149..172 CDD:275380 8/22 (36%)
leucine-rich repeat 173..196 CDD:275380 4/22 (18%)
LRR_8 197..>229 CDD:290566 10/31 (32%)
leucine-rich repeat 197..220 CDD:275380 7/22 (32%)
LRRCT 229..277 CDD:214507 17/53 (32%)
Ig 296..376 CDD:143165
CPN2NP_001073982.3 LRRNT 21..53 CDD:214470
leucine-rich repeat 30..53 CDD:275380
leucine-rich repeat 75..98 CDD:275380
LRR 1 98..119
leucine-rich repeat 99..122 CDD:275380 1/1 (100%)
LRR_8 121..181 CDD:290566 16/73 (22%)
LRR 2 122..143 8/23 (35%)
leucine-rich repeat 123..146 CDD:275380 8/25 (32%)
LRR 3 146..167 5/31 (16%)
leucine-rich repeat 147..170 CDD:275380 5/33 (15%)
LRR_RI 149..>356 CDD:238064 42/217 (19%)
LRR_8 169..229 CDD:290566 12/59 (20%)
LRR 4 170..191 6/20 (30%)
leucine-rich repeat 171..194 CDD:275380 6/22 (27%)
LRR 5 194..215 4/20 (20%)
leucine-rich repeat 195..218 CDD:275380 4/22 (18%)
LRR_8 218..277 CDD:290566 7/58 (12%)
LRR 6 218..239 5/20 (25%)
leucine-rich repeat 219..242 CDD:275380 6/22 (27%)
LRR 7 242..263 1/20 (5%)
leucine-rich repeat 243..266 CDD:275380 1/22 (5%)
LRR 8 266..287 0/20 (0%)
leucine-rich repeat 267..290 CDD:275380 0/22 (0%)
LRR 9 290..311 7/20 (35%)
leucine-rich repeat 291..314 CDD:275380 9/22 (41%)
LRR_8 294..349 CDD:290566 18/54 (33%)
LRR 10 314..335 7/20 (35%)
leucine-rich repeat 315..338 CDD:275380 8/22 (36%)
LRR 11 338..359 4/20 (20%)
leucine-rich repeat 339..359 CDD:275380 4/19 (21%)
LRR 12 362..383 7/20 (35%)
leucine-rich repeat 363..382 CDD:275380 6/18 (33%)
leucine-rich repeat 387..399 CDD:275378 6/11 (55%)
LRRCT 395..446 CDD:214507 17/53 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.