DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and LRRC15

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001128529.2 Gene:LRRC15 / 131578 HGNCID:20818 Length:587 Species:Homo sapiens


Alignment Length:330 Identity:89/330 - (26%)
Similarity:136/330 - (41%) Gaps:71/330 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 QIPELRR--------EEF---LLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRE 137
            |:|:|.|        :|.   :...:||:.:::|.:..|..:....|..|..|..|.||.|:|..
Human   273 QLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF 337

  Fly   138 LHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISL 202
            :.||.|.||.:||.:.::.|.::.|..::|..|:.|..|..:||||||:..::||....|.||.|
Human   338 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQL 402

  Fly   203 EQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAI--SKRLYTPPTD-CQEPPQLRG 264
            :.|:|.:|....|..|.||..|.|..|.|.|..::...|::.:  ..||.|.... |..|..:||
Human   403 QNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRG 467

  Fly   265 KLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPR----PNVTWVYNKRPLQQYDPR 325
                                 :|.|..| .|:::|.  |..|.    |...| |...|       
Human   468 ---------------------Q
SLIIIN-VNVAVPS--VHVPEVPSYPETPW-YPDTP------- 500

  Fly   326 VRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYT-----CVADNRG--GRAEAEFQLLVSGDY 383
                    ..|:..|...|:||      .|....||     .|.|:|.  |..:|:..|.::...
Human   501 --------SYPDTTSVSSTTEL------TSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIV 551

  Fly   384 AGAVS 388
            .|.|:
Human   552 IGIVA 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 25/86 (29%)
leucine-rich repeat 76..100 CDD:275380 5/26 (19%)
LRR_8 99..159 CDD:290566 20/59 (34%)
leucine-rich repeat 101..124 CDD:275380 4/22 (18%)
LRR 122..145 CDD:197688 10/22 (45%)
leucine-rich repeat 125..148 CDD:275380 11/22 (50%)
LRR_8 148..207 CDD:290566 21/58 (36%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
leucine-rich repeat 173..196 CDD:275380 10/22 (45%)
LRR_8 197..>229 CDD:290566 13/31 (42%)
leucine-rich repeat 197..220 CDD:275380 9/22 (41%)
LRRCT 229..277 CDD:214507 11/50 (22%)
Ig 296..376 CDD:143165 20/90 (22%)
LRRC15NP_001128529.2 LRR_8 60..119 CDD:290566
LRR_RI 63..309 CDD:238064 8/35 (23%)
LRR_8 88..167 CDD:290566
leucine-rich repeat 88..108 CDD:275380
leucine-rich repeat 109..156 CDD:275380
leucine-rich repeat 157..180 CDD:275380
LRR_8 180..239 CDD:290566
leucine-rich repeat 181..204 CDD:275380
leucine-rich repeat 205..228 CDD:275380
LRR_8 228..287 CDD:290566 4/13 (31%)
leucine-rich repeat 229..252 CDD:275380
leucine-rich repeat 253..276 CDD:275380 1/2 (50%)
leucine-rich repeat 277..300 CDD:275380 3/22 (14%)
LRR_8 299..359 CDD:290566 20/59 (34%)
LRR_4 299..340 CDD:289563 12/40 (30%)
leucine-rich repeat 301..324 CDD:275380 4/22 (18%)
LRR_4 324..364 CDD:289563 15/39 (38%)
leucine-rich repeat 325..348 CDD:275380 11/22 (50%)
leucine-rich repeat 349..370 CDD:275380 5/20 (25%)
LRR_8 372..430 CDD:290566 23/57 (40%)
leucine-rich repeat 373..393 CDD:275380 9/19 (47%)
leucine-rich repeat 397..418 CDD:275380 8/20 (40%)
TPKR_C2 429..>468 CDD:301599 11/59 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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