DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Chad

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_031715.1	Gene:	Chad / 12643	MGIID:	1096866	Length:	358	Species:	Mus musculus

Alignment Length:	346	Identity:	80/346 - (23%)
Similarity:	123/346 - (35%)	Gaps:	107/346 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLD 79
            |...||..||.|..|.|..|....      .|||  :...:...|....|.|||: :|...::|:
Mouse     1 MARALLFSLVFLAILLPALAACPQ------NCHC--HGDLQHVICDKVGLQKIPK-VSETTKLLN 56

  Fly    80 FAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFA 144
            ...|..|.|....|  ..:||:..:.|::|.|:||...||:||..||.|.||.|.||.|..|.|.
Mouse    57 LQRNNFPVLAANSF--RTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFD 119

  Fly   145 GLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSH 209
            .|.:|..:.:::|::..||..|...|..|..::..||::|:::...|.|...|..:.|.:|.||.
Mouse   120 DLTELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSS 184

  Fly   210 LHKETFKDLQ-----------------------------KLMH---------------------- 223
            |...:..|::                             ||.|
Mouse   185 LQPGSLDDVENLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLW 249

  Fly   224 --------------------------------------------LSLQGNAWNCSCELQDFRDFA 244
                                                        |:|..|.|.|:|:|:..|.:
Mouse   250 LDNTNLEKFSDAAFSGVTTLKHVHLDNNRLNQLPSSFPFDNLETLTLTNNPWKCTCQLRGLRRW- 313

  Fly   245 ISKRLYTPPTDCQEPPQLRGK 265
            :..:...|...|..|.:.:|:
Mouse   314 LEAKASRPDATCSSPAKFKGQ 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/83 (36%)
		leucine-rich repeat	76..100	CDD:275380	5/23 (22%)
		LRR_8	99..159	CDD:290566	25/59 (42%)
		leucine-rich repeat	101..124	CDD:275380	9/22 (41%)
		LRR	122..145	CDD:197688	12/22 (55%)
		leucine-rich repeat	125..148	CDD:275380	12/22 (55%)
		LRR_8	148..207	CDD:290566	15/58 (26%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	12/126 (10%)
		leucine-rich repeat	197..220	CDD:275380	7/51 (14%)
		LRRCT	229..277	CDD:214507	10/37 (27%)
		Ig	296..376	CDD:143165
Chad	NP_031715.1	LRRNT	22..48	CDD:279764	8/34 (24%)
		LRR 1	51..72		5/22 (23%)
		leucine-rich repeat	52..75	CDD:275380	5/24 (21%)
		LRR_8	74..134	CDD:290566	25/59 (42%)
		LRR 2	75..96		8/20 (40%)
		leucine-rich repeat	76..99	CDD:275380	9/22 (41%)
		LRR_RI	<89..281	CDD:238064	39/191 (20%)
		LRR 3	99..120		11/20 (55%)
		leucine-rich repeat	100..123	CDD:275380	12/22 (55%)
		LRR 4	123..144		5/20 (25%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_8	147..206	CDD:290566	13/58 (22%)
		LRR 5	147..168		5/20 (25%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR 6	171..192		6/20 (30%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRR 7	195..216		0/20 (0%)
		leucine-rich repeat	196..219	CDD:275380	0/22 (0%)
		LRR 8	219..240		3/20 (15%)
		LRR_8	220..279	CDD:290566	3/58 (5%)
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		LRR 9	244..265		0/20 (0%)
		leucine-rich repeat	245..268	CDD:275380	0/22 (0%)
		LRR 10	268..289		0/20 (0%)
		leucine-rich repeat	269..291	CDD:275380	0/21 (0%)
		LRRCT	299..346	CDD:214507	10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..358		3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910