DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and VASN

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_612449.2	Gene:	VASN / 114990	HGNCID:	18517	Length:	673	Species:	Homo sapiens

Alignment Length:	888	Identity:	165/888 - (18%)
Similarity:	264/888 - (29%)	Gaps:	340/888 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLGVLVVLMALPPPTAGTTDWMQSCGT-CHCQWNSGKKSADCKNKALTKIPQDMSNE-------- 74
            ||..|::|:||.|       .:|.|.: |.|   |..::..|..:..|.:|:|:..:
Human     7 LLLPLLLLLALGP-------GVQGCPSGCQC---SQPQTVFCTARQGTTVPRDVPPDTVGLYVFE 61

  Fly    75 ----------------MQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLH 123
                            :|:||.:.|||..|....|  ..|.|:..:.|....:.|:..|.|:||.
Human    62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVF--QPLANLSNLDLTANRLHEITNETFRGLR 124

  Fly   124 ILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLP------------NH----------- 165
            .|..|.|..||||.:.||.|..|::|..:.:.:||:..||            :|
Human   125 RLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPGIL 189

  Fly   166 ---------------------LFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQN-RLS 208
                                 ||..|..|..::..:|:|.:|. .|..|...|:.:.|..| |::
Human   190 DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-PVIRGLRGLTRLRLAGNTRIA 253

  Fly   209 HLHKETFKDLQKLM-----HLSLQG-------------------NAWNCSCELQDF----RDFAI 245
            .|..|....|..|.     :||||.                   |.:||.|.|..|    |:..:
Human   254 QLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHV 318

  Fly   246 SKRLYTP-PTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPN 309
            :  |.:| .|.|..||:..|:|..|:...:|.|...   :..:.:......:..|..:..|..|
Human   319 T--LASPEETRCHFPPKNAGRLLLELDYADFGCPAT---TTTATVPTTRPVVREPTALSSSLAP- 377

  Fly   310 VTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGV-RASDKGAYTCVADNRGGRAEA 373
             ||                |:..|...|.||...|:...:..| :..|....||:   .||....
Human   378 -TW----------------LSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCL---NGGTCHL 422

  Fly   374 ----EFQLLVSGDYAGAVSASDGMGMGAIGAPT-IDPQTNMFLIICLIITTLLLLLLVAVLTLFW 433
                ....|....:.|....|. ||.|...:|| :.|:.
Human   423 GTRHHLACLCPEGFTGLYCESQ-MGQGTRPSPTPVTPRP-------------------------- 460

  Fly   434 YCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRTDIESV 498
                                                      .:||...:.||.....|..::..
Human   461 ------------------------------------------PRSLTLGIEPVSPTSLRVGLQRY 483

  Fly   499 DGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPA 563
            ..|..| :::
Human   484 LQGSSV-QLR------------------------------------------------------- 492

  Fly   564 RVPPTSPSMQSSQSNI--PDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAPHNGFMTLQHPK 626
                   |::.:..|:  ||:.:..:|.|.||.....|.:.|:..|....|.....     :.|:
Human   493 -------SLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGPG-----RVPE 545

  Fly   627 SRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGV 691
            .......|.|..: .|.:|..:.|.::.:                    .|.|.||.:.:.....
Human   546 GEEACGEAHTPPA-VHSNHAPVTQAREGN--------------------LPLLIAPALAAVLLAA 589

  Fly   692 VMKQGYMTIPRKPRAPSWAPSTSGAAGHGS--IQLSEFQSPTSPNPSETGTATTAELQAEPVYDN 754
            :...|.....|:.||.:.|....|..|.|:  ::|...:.|..|.|
Human   590 LAAVGAAYCVRRGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGP------------------- 635

  Fly   755 LGLRTTAGGNSTLNLTKIAGSQ--------GGAGQQYSMRDRP 789
               :.|.||...|.    :||:        .|.|.|..:..:|
Human   636 ---KATEGGGEALP----SGSECEVPLMGFPGPGLQSPLHAKP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/83 (36%)
		leucine-rich repeat	76..100	CDD:275380	9/23 (39%)
		LRR_8	99..159	CDD:290566	20/59 (34%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	11/22 (50%)
		leucine-rich repeat	125..148	CDD:275380	11/22 (50%)
		LRR_8	148..207	CDD:290566	18/103 (17%)
		leucine-rich repeat	149..172	CDD:275380	9/66 (14%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	12/56 (21%)
		leucine-rich repeat	197..220	CDD:275380	7/23 (30%)
		LRRCT	229..277	CDD:214507	17/52 (33%)
		Ig	296..376	CDD:143165	17/84 (20%)
VASN	NP_612449.2	LRR 8	217..238		5/21 (24%)
		leucine-rich repeat	218..240	CDD:275380	6/22 (27%)
		LRR 9	240..262		6/21 (29%)
		leucine-rich repeat	241..265	CDD:275380	7/23 (30%)
		LRR 10	265..287		5/21 (24%)
		leucine-rich repeat	266..286	CDD:275380	5/19 (26%)
		LRRCT	298..349	CDD:214507	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..404		11/63 (17%)
		EGF	409..440	CDD:278437	6/33 (18%)
		fn3	466..535	CDD:278470	16/131 (12%)
		LRRNT	23..54	CDD:214470	8/33 (24%)
		leucine-rich repeat	34..56	CDD:275380	4/21 (19%)
		LRR 1	52..74		0/21 (0%)
		leucine-rich repeat	57..77	CDD:275380	0/19 (0%)
		LRR_8	62..112	CDD:290566	11/51 (22%)
		LRR_4	76..117	CDD:289563	12/42 (29%)
		LRR 2	77..98		8/22 (36%)
		leucine-rich repeat	78..101	CDD:275380	9/24 (38%)
		LRR_8	101..158	CDD:290566	19/56 (34%)
		LRR_4	101..141	CDD:289563	14/39 (36%)
		LRR 3	101..122		5/20 (25%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR_8	124..228	CDD:290566	22/103 (21%)
		LRR 4	125..146		10/20 (50%)
		leucine-rich repeat	126..149	CDD:275380	11/22 (50%)
		LRR 5	149..170		5/20 (25%)
		leucine-rich repeat	150..193	CDD:275380	6/42 (14%)
		LRR 6	171..191		1/19 (5%)
		LRR 7	193..214		2/20 (10%)
		leucine-rich repeat	194..217	CDD:275380	3/22 (14%)
		LRR_8	216..273	CDD:290566	14/57 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910