DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRRN2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_006329.2	Gene:	LRRN2 / 10446	HGNCID:	16914	Length:	713	Species:	Homo sapiens

Alignment Length:	628	Identity:	133/628 - (21%)
Similarity:	197/628 - (31%)	Gaps:	233/628 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQ---WNSGKKS------ADCKNKALTKIPQ 69
            |.||:..:|:..:|..........|...| ..|.||   |.:.:.|      .||.:..||.:|.
Human     1 MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPP 65

  Fly    70 -------------------DMSN-----EMQVLDFAHNQ-----------IPEL----------- 88
                               |.|.     .:..||.:.|.           :|:|
Human    66 ALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLT 130

  Fly    89 RREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIE-------------------------- 127
            |.|:...|||.::.:::|.:..:..:...||.||..|:.
Human   131 RLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILM 195

  Fly   128 ----------------------------------------------------------------- 127

Human   196 IGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQV 260

  Fly   128 -----LDLSGNRIRELHPGTFAGLEKLRNVIINN-NEIEVLPNHLFVNLSFLSRIEFRNN-RLRQ 185
                 |||:.|.::.:.||.||.:..|:.:.:|| .|:..:.....|||..|::::..|| ||..
Human   261 PGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSF 325

  Fly   186 VQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLY 250
            :....|.....:..:.|..|.||.||::|.:.|..|..:.|.||...|.|.::.........|..
Human   326 IHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFI 390

  Fly   251 TP-PTDCQEPPQLRGKLWSEVPSENFA--CRPRILGSVRSFIE----ANHDNISLPCRIVGSPRP 308
            .| .|.|.|||.|:.....|||.....  |.|.|  |.|||..    |:.:::.|.||.:..|.|
Human   391 EPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLI--SPRSFPPSLQVASGESMVLHCRALAEPEP 453

  Fly   309 NVTWVYNKRPLQQYDPRVRVLTSVEQ------MPEQPSQVLTSELRIVGVRASDKGAYTCVADN- 366
            .:.||         .|....||....      .||.     |.|||  .|.|.:.|.|||||.|
Human   454 EIYWV---------TPAGLRLTPAHAGRRYRVYPEG-----TLELR--RVTAEEAGLYTCVAQNL 502

  Fly   367 -----------------RGGRAEAE-FQLLVSGDYAGAV------------------SASDGMGM 395
                             :.||.|.: .:|.|...:...:                  |||...|.
Human   503 VGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASSLRGQ 567

  Fly   396 GAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRI 438
            ||.....:...|:.:     .||.||      ..|.:|.|.::
Human   568 GATALARLPRGTHSY-----NITRLL------QATEYWACLQV 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	28/202 (14%)
		leucine-rich repeat	76..100	CDD:275380	10/45 (22%)
		LRR_8	99..159	CDD:290566	17/156 (11%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	9/118 (8%)
		leucine-rich repeat	125..148	CDD:275380	9/118 (8%)
		LRR_8	148..207	CDD:290566	15/60 (25%)
		leucine-rich repeat	149..172	CDD:275380	7/23 (30%)
		leucine-rich repeat	173..196	CDD:275380	6/23 (26%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	14/50 (28%)
		Ig	296..376	CDD:143165	28/104 (27%)
LRRN2	NP_006329.2	leucine-rich repeat	51..69	CDD:275380	5/17 (29%)
		LRR_RI	62..288	CDD:238064	27/225 (12%)
		LRR 1	70..91		2/20 (10%)
		leucine-rich repeat	71..94	CDD:275380	2/22 (9%)
		LRR 2	94..115		3/20 (15%)
		leucine-rich repeat	95..118	CDD:275380	3/22 (14%)
		LRR_8	117..177	CDD:290566	13/59 (22%)
		LRR 3	118..139		3/20 (15%)
		leucine-rich repeat	119..142	CDD:275380	6/22 (27%)
		LRR 4	142..163		3/20 (15%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		LRR_8	165..222	CDD:290566	1/56 (2%)
		LRR 5	166..187		1/20 (5%)
		leucine-rich repeat	167..190	CDD:275380	1/22 (5%)
		LRR 6	190..211		0/20 (0%)
		leucine-rich repeat	191..214	CDD:275380	0/22 (0%)
		LRR_RI	209..>372	CDD:238064	33/162 (20%)
		LRR_8	214..273	CDD:290566	4/58 (7%)
		LRR 7	214..235		0/20 (0%)
		leucine-rich repeat	215..238	CDD:275380	0/22 (0%)
		LRR 8	238..259		0/20 (0%)
		leucine-rich repeat	239..262	CDD:275380	0/22 (0%)
		LRR 9	262..283		7/20 (35%)
		leucine-rich repeat	263..286	CDD:275380	8/22 (36%)
		LRR 10	286..305		4/18 (22%)
		leucine-rich repeat	287..311	CDD:275380	7/23 (30%)
		LRR_8	310..371	CDD:290566	18/60 (30%)
		LRR 11	311..333		6/21 (29%)
		leucine-rich repeat	312..334	CDD:275380	6/21 (29%)
		LRR 12	336..357		7/20 (35%)
		leucine-rich repeat	337..360	CDD:275378	8/22 (36%)
		leucine-rich repeat	361..373	CDD:275378	4/11 (36%)
		TPKR_C2	369..412	CDD:301599	12/42 (29%)
		I-set	430..514	CDD:254352	26/99 (26%)
		Ig	438..514	CDD:299845	25/91 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910