DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and tlr9

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_017948709.2	Gene:	tlr9 / 100494387	XenbaseID:	XB-GENE-486908	Length:	1035	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	86/389 - (22%)
Similarity:	143/389 - (36%)	Gaps:	93/389 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLLGVLVVLMALPPPTAGTTDWMQSCGTCH---CQWNSGKKSADCKNKALTKIPQDMSNEMQVLD 79
            |:||..:....:|                |   |...:...:..|:.:.|..:|..:|..::|.|
Frog    25 LILGACLAFCKIP----------------HFLPCDDFNNASTVICRERQLIHVPHIVSQSVKVFD 73

  Fly    80 FAHNQIPELRREEFLLAGLPNVHKIFLR-NC------TIQEVHR-----EAFKGLHILIELDLSG 132
            .|.|:|..|....|  :|:||:..:.|. ||      ..:|:.|     .|...|..|..|||||
Frog    74 LAINEIRLLANSTF--SGVPNLVILNLSDNCQPSNLRPYKEICRLIIEPHALVSLKSLTNLDLSG 136

  Fly   133 NRIRELHPGTFAGLEKLRNVIINNNEIEVL---------------------------PNHL---- 166
            |.:..:.|..    |.::.:.:|.|:|.::                           |.||
Frog   137 NSLTSIPPLP----ENIKFLNLNLNQIHMISGWEFSRLNNVKMIRLGYNCFYSKQCEPFHLSDSA 197

  Fly   167 FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAW 231
            |:|..||..:....|.:.....::   ..::..:.|.:|::|.:.:|...:|..|..|.||.|..
Frog   198 FINNEFLEELALSFNNITSFPQNL---PSSIRILDLSENKISKIDREDLCNLNNLHSLDLQWNCQ 259

  Fly   232 NCSCELQDFRDFAISKRLYTPP--TDCQEP---PQLRGKLWSEVPSENFACRPRILGSVRSFIEA 291
            .|...||.......:..|...|  .||...   ..|||.....:.|..|:....:...|.|
Frog   260 RCDHALQACYPCKNNSALLLVPGVFDCLHKLSYLNLRGNSLHTLHSSLFSSLTNLSHLVLS---- 320

  Fly   292 NHDN-ISLPCRIVGSPRPNVTWV---YNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVG 351
              || ::|......|...||..:   :|.:|...|: |:.:.::|.:|..      ...:.|||
Frog   321 --DNFLNLETETFFSALTNVKELNLDFNFKPYSMYE-RLVLNSNVARMKS------LERITIVG 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	28/95 (29%)
		leucine-rich repeat	76..100	CDD:275380	8/23 (35%)
		LRR_8	99..159	CDD:290566	20/71 (28%)
		leucine-rich repeat	101..124	CDD:275380	7/34 (21%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	13/89 (15%)
		leucine-rich repeat	149..172	CDD:275380	8/53 (15%)
		leucine-rich repeat	173..196	CDD:275380	2/22 (9%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		LRRCT	229..277	CDD:214507	13/52 (25%)
		Ig	296..376	CDD:143165	13/59 (22%)
tlr9	XP_017948709.2	leucine-rich repeat	69..92	CDD:275380	8/24 (33%)
		PLN00113	82..>592	CDD:215061	71/316 (22%)
		leucine-rich repeat	93..128	CDD:275380	7/34 (21%)
		leucine-rich repeat	129..148	CDD:275380	8/22 (36%)
		leucine-rich repeat	149..172	CDD:275380	3/22 (14%)
		leucine-rich repeat	173..203	CDD:275380	5/29 (17%)
		leucine-rich repeat	204..224	CDD:275380	2/22 (9%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		leucine-rich repeat	249..289	CDD:275380	12/39 (31%)
		leucine-rich repeat	290..311	CDD:275380	5/20 (25%)
		leucine-rich repeat	314..337	CDD:275380	6/28 (21%)
		leucine-rich repeat	353..394	CDD:275380	7/30 (23%)
		leucine-rich repeat	395..418	CDD:275380
		leucine-rich repeat	482..504	CDD:275380
		leucine-rich repeat	505..529	CDD:275380
		leucine-rich repeat	530..553	CDD:275380
		inl_like_NEAT_1	<534..>767	CDD:411101
		leucine-rich repeat	554..583	CDD:275380
		leucine-rich repeat	584..637	CDD:275380
		leucine-rich repeat	607..629	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..686	CDD:275380
		leucine-rich repeat	687..708	CDD:275380
		leucine-rich repeat	709..732	CDD:275380
		leucine-rich repeat	733..751	CDD:275380
		PCC	738..>821	CDD:188093
		TIR_2	875..1017	CDD:419986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910