DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lrfn2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_031758515.1	Gene:	lrfn2 / 100491687	XenbaseID:	XB-GENE-6035533	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	739	Identity:	162/739 - (21%)
Similarity:	260/739 - (35%)	Gaps:	170/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFA 81
            ||:.|:.|::.:.|.             .|.||..|......|..|.|..:|.|:......|...
Frog     8 LLVFGMAVMVNSCPK-------------YCVCQNLSESLGTLCPTKGLLFVPMDIDRRTVELRLG 59

  Fly    82 HNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGL 146
            .|.|..:.|::|  |.:..:..:.|...||..:...:|..|..|..|.|..||:..|....|.||
Frog    60 GNFIISINRQDF--ANMTGLVDLTLSRNTISYIQPYSFIDLESLRSLHLDSNRLTNLGDDVFRGL 122

  Fly   147 EKLRNVIINNNEIEVLPNHLFVN-LSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHL 210
            ..|:::|:|||::..:....|.: |..|..::...|.|:.|........:.|..:||:.|.:.::
Frog   123 INLQHLIMNNNQLNSIAEDAFEDLLQTLEDLDLSYNNLKTVPWDAVRRMVNLHQLSLDHNLIYYI 187

  Fly   211 HKETFKDLQKL-----------------------------------MHLSLQGNAWNCSCELQDF 240
            .:.||:||.||                                   :.||..||..:|:|||...
Frog   188 TEGTFQDLNKLARLDLTSNRLQKLPPDPIFARSQISMTSATPFSPPLSLSFGGNPLHCNCELLWL 252

  Fly   241 RDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGS-VRSFIEANHDNISLPCRIVG 304
            |.......:.|    |..|..|:|:.:..|..|.|.|.|.::.. .:..:.......||.|:.||
Frog   253 RRLDREDDMET----CASPSALKGRYFWYVREEEFVCEPPLITQYTQRLLVLEGQTASLKCKAVG 313

  Fly   305 SPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGG 369
            .|.|.:.||.....|.....|..|..:             ..|.|:...:.|.|.:||:|.|..|
Frog   314 DPLPVIHWVAPDGRLIGNSSRTTVYDN-------------GTLDILITTSKDYGTFTCIAANAAG 365

  Fly   370 RAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMF-------------------LIICL 415
            ...|..:|.:    ......|:|.|.      |..|::.:.                   .::..
Frog   366 ELTAPVELSI----VQIPHVSNGTGR------TAPPKSRLSDITSSTKSNRGEVKTAPEKAVVVS 420

  Fly   416 IITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHN-----GSMLEGS----- 470
            .:|:...|:..:|...   ..::|.||.... .|.|.::..:|....|     .:::.|:
Frog   421 EVTSSTALVKWSVSKA---APKVKMYQLQYN-CSDDEVLIYRMIPASNKAFVVNNLVSGTAYDLC 481

  Fly   471 --VIMEMQKSLLNEVNPVEKPP--RRTDIESVD-------GGDDVLE----IKKTLLDDTVY--- 517
              .|.:...:.|...|.|....  .:.|.:...       ||..:|.    |..|||...|.
Frog   482 VLAIWDDTATTLTATNIVGCAQFFTQEDYQQCQSMHSQFLGGTMILVIGGIIVATLLVFIVILMV 546

  Fly   518 ---VANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPP----------DLLAFPARVPPTS 569
               :.|||:.:      |::.|..  ...|...:...|..||          :|:.|......:|
Frog   547 RYKICNHSQGK------MANVTNV--YSQTNGGNTVQNGAPPQTNPKVVVRNELMEFQCGSAHSS 603

  Fly   570 PSMQSSQSNIPDQVIYGIRSPPSLTS----PVYTHMTPHGIYGTKTMTAPHNGFMTLQHPKSRNL 630
            .|..||..|.||...|.:.|.||..|    ||  ..:.|.|  .:.|.|    |.:|:....:..
Frog   604 VSSSSSSVNSPDGDDYSLHSNPSTLSNKWRPV--SRSKHNI--DRLMGA----FASLELRCQKKE 660

  Fly   631 ALIATTNSSRQHQH-------HHQ 647
            ..:.:..|:..||.       ||:
Frog   661 DTVDSRTSTTAHQSDKEPLLGHHE 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	15/59 (25%)
		leucine-rich repeat	149..172	CDD:275380	7/23 (30%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	12/66 (18%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	14/47 (30%)
		Ig	296..376	CDD:143165	22/79 (28%)
lrfn2	XP_031758515.1	LRR_8	51..111	CDD:404697	15/61 (25%)
		leucine-rich repeat	53..76	CDD:275380	6/24 (25%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..160	CDD:404697	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	148..208	CDD:404697	14/59 (24%)
		leucine-rich repeat	150..173	CDD:275380	4/22 (18%)
		leucine-rich repeat	174..197	CDD:275380	8/22 (36%)
		LRRCT	241..285	CDD:214507	14/47 (30%)
		Ig	288..375	CDD:416386	23/99 (23%)
		Ig strand A	288..291	CDD:409353	0/2 (0%)
		Ig strand A'	295..298	CDD:409353	0/2 (0%)
		Ig strand B	304..312	CDD:409353	3/7 (43%)
		Ig strand C	318..323	CDD:409353	1/4 (25%)
		Ig strand C'	326..328	CDD:409353	0/1 (0%)
		Ig strand D	334..338	CDD:409353	1/3 (33%)
		Ig strand E	341..345	CDD:409353	1/3 (33%)
		Ig strand F	355..362	CDD:409353	3/6 (50%)
		Ig strand G	365..375	CDD:409353	3/9 (33%)
		fn3	417..485	CDD:394996	11/71 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910