DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and flrt1

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_017948905.2	Gene:	flrt1 / 100486965	XenbaseID:	XB-GENE-495403	Length:	679	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	144/688 - (20%)
Similarity:	234/688 - (34%)	Gaps:	229/688 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MALPPPTAGTTDWMQSC-------------GTCH--CQWNSGKKSADCKNKALTKIPQDMSNEMQ 76
            :|:...|....||:..|             ..|.  |:.::|  ...|.::.||.||.|:.::..
Frog    29 VAMTTATLDLRDWLFLCYGLIAFLTEVIDSTNCPYVCRCDNG--FIYCNDRGLTSIPPDIPDDAT 91

  Fly    77 VLDFAHNQI------PELRR--------------EEF------------------------LLAG 97
            .|...:|||      |||:.              :||                        .|:.
Frog    92 TLYLQNNQINNAGVPPELKTKTNVKVIYLYENDLDEFPVNLPHSLRELHLQDNNIRSVTRDSLSR 156

  Fly    98 LPNVHKIFLRNCTIQEVHRE--AF--------------------KGL-HILIELDLSGNRIRELH 139
            :|.:.|:.|.:.::..|..|  ||                    .|| |.|.||.|..|||..:.
Frog   157 IPLIEKLHLDDNSVSTVSIEDDAFLDSHQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRISTIP 221

  Fly   140 PGTFAGLEKLRNVIINNN-------------------EIEVLPNHLF---VNL--SFLSRIEFRN 180
            ...|.||..||.::::.|                   |:.::.|.|.   |||  :.|.::..::
Frog   222 LHAFKGLNNLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPVNLPSTHLQKLYLQD 286

  Fly   181 NRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAI 245
            |.:..:.....:....|..:.|..|.|:.|.:..|.||:.|..|.|:.|.|.|.|.|...||:..
Frog   287 NAITHIPYSSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNNPWFCGCNLMWLRDWVK 351

  Fly   246 SKRLYTPPTD--CQEPPQLRGKLWSEVPSENFAC-----------------RPRI---------- 281
            ::........  ||.|.::||....::..|...|                 .|.|
Frog   352 ARAAVVNVRGLMCQGPEKVRGMAIKDITHELDECFEGGPQSNSASARATPGSPIITTPAQGSLFT 416

  Fly   282 LGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQ------------------------Y 322
            |.|.|..|:....|:..|.....|.:   ..|.|.:||..                        :
Frog   417 LKSKRPRIQLPDSNVDYPMETGTSTK---ALVINVKPLTADSIRITWKAFHPASSFRLSWLRLGH 478

  Fly   323 DPRVRVLTSVEQMPEQPSQVLTS-ELR---IVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDY 383
            .|.|..:|......::...:||: |.|   |:.:...|.| .|.:||.....|:||     :.|.
Frog   479 SPAVGSITETLVQGDKTEYLLTALEPRSTYIICMVTMDTG-NTYLADESPVCAKAE-----TADV 537

  Fly   384 AGAVSASDGMGMGAIGAPTIDPQTNMFL--IICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTT 446
            .|..:..:       .....||...:.|  ||...:|.:.|.|::|  ::.||..|
Frog   538 YGPTTTLN-------REQNADPLAGLPLAGIIGGAVTLVFLFLILA--SICWYVHR--------- 584

  Fly   447 MMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRTDIESVDGG----DDVLEI 507
              :|..|       ||..:...||                    |:.| :.|:.|    :.:|||
Frog   585 --AGQLL-------THERAYSRGS--------------------RKKD-DYVESGTKKDNSILEI 619

  Fly   508 KKTLLDDTVYVANHSRDEEAV-SVAMSDTTTTPRSRHT 544
            :...|.......:.|::|..: ::..|:.|:..:|.||
Frog   620 RGPGLQMLPINPHRSKEEYVIHTIFPSNGTSLYKSTHT 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	34/169 (20%)
		leucine-rich repeat	76..100	CDD:275380	10/67 (15%)
		LRR_8	99..159	CDD:290566	23/101 (23%)
		leucine-rich repeat	101..124	CDD:275380	8/45 (18%)
		LRR	122..145	CDD:197688	10/23 (43%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	14/82 (17%)
		leucine-rich repeat	149..172	CDD:275380	9/46 (20%)
		leucine-rich repeat	173..196	CDD:275380	2/22 (9%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	13/49 (27%)
		Ig	296..376	CDD:143165	22/107 (21%)
flrt1	XP_017948905.2	PRK15370	<65..>388	CDD:185268	74/324 (23%)
		leucine-rich repeat	92..114	CDD:275378	7/21 (33%)
		leucine-rich repeat	115..135	CDD:275380	2/19 (11%)
		leucine-rich repeat	136..159	CDD:275380	1/22 (5%)
		leucine-rich repeat	160..185	CDD:275380	6/24 (25%)
		leucine-rich repeat	186..206	CDD:275380	2/19 (11%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..256	CDD:275380	3/24 (13%)
		leucine-rich repeat	257..278	CDD:275380	6/20 (30%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		FN3	446..510	CDD:214495	10/63 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910