DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lrfn4b

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_021333806.1	Gene:	lrfn4b / 100149980	ZFINID:	ZDB-GENE-070705-473	Length:	1131	Species:	Danio rerio

Alignment Length:	900	Identity:	163/900 - (18%)
Similarity:	261/900 - (28%)	Gaps:	328/900 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLS------------HLHKETFKDLQ 219
            |::||...:::...:.|...|     ...||....||..:::            |..:|||..:.
Zfish    71 FIDLSLAKKLKIPTHLLPHPQ-----SVTALDGRPLEPGKVTEATQSLKLTIAKHQQEETFYLID 130

  Fly   220 KLMHLSLQGNA------------------WNCSC--------------ELQDFRD---------- 242
            ...:..:.|:.                  |:.||              |.||..|
Zfish   131 SPEYPVILGHPWLHRHNPHINWSTGSILDWSPSCHFTCFTQSLSAPHPEPQDSVDLSQVPAVYHK 195

  Fly   243 ----FAISKRLYTP---PTDC-------QEPPQLRGKLWSEVPSENFACRPRILGSVRS-FIEAN 292
                |:.|:....|   |.||       ..||  ||:::|..|.|..|....|..|:.: .|.|:
Zfish   196 FRAVFSKSRATSLPPHRPYDCAIDLLPGSSPP--RGRVFSLSPPEQAAMNAYIQESLATGIIRAS 258

  Fly   293 HDNISLPCRIVGSP----RPNVTW-VYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTS-ELRIVG 351
            ..........||..    ||.:.: ..||..::...|...:.|:.|.:  |.:.:.|. :||
Zfish   259 TSPAGAGFFFVGKKDGGLRPCIDYRGLNKITIRNRYPLPLMATAFELL--QGASIFTKLDLR--- 318

  Fly   352 VRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLI 416
                  .||..|...:|...:..|. ..:|.|...|     |..|...||.             :
Zfish   319 ------NAYHLVRIRQGDEWKTAFN-TPTGHYEYLV-----MPFGLTNAPA-------------V 358

  Fly   417 ITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLN 481
            ...|:..:|..:|.:|     :..|..|.       ||.||..:.|     ||.|...:|:.|.|
Zfish   359 FQALINDVLRDMLNIF-----VFVYLDDI-------LIFSKSMEEH-----EGHVSRVLQRLLEN 406

  Fly   482 EVNPVEKPPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSR---DEEAVSVAMS-DTTTTPRSR 542
            .:  ..||.:             .|...:|.....|:.....   |...:...:: ...||.:..
Zfish   407 HL--FVKPEK-------------CEFHVSLTKFLGYIVTPGHLEMDPSKIKAVLNWPIPTTVKEV 456

  Fly   543 HTYVDDAYANSLPPDLLAFPARVPPTS-------------PSMQSSQSNIPDQVIYG-IRSPPSL 593
            ..:|  .:||.....:..|.:.|.|.:             |...::..::.|:.... |.|.|:.
Zfish   457 QRFV--GFANFYRKFIRNFSSVVAPLTALTKGGGVKIEWGPKAAAAFQDLKDRFTSAPILSIPNP 519

  Fly   594 TSPVYTHMTPHGIYGTKTMTAPHNGFMTLQHP---KSRNLA------------LIATTNSSRQHQ 643
            ..|....:....: |...:.:..|....| ||   .||.|:            |:|...:..:.:
Zfish   520 DIPFMVEVDASDV-GVGAILSQRNEDGKL-HPCAFMSRRLSNAERNYHVGDRELLAVKLALEEWR 582

  Fly   644 H-----HHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRK 703
            |     .|..|....|.:....||.:|                                    ..
Zfish   583 HWLEGARHPFQVLTDHKNLEYLQQAKQ------------------------------------LN 611

  Fly   704 PRAPSWAPSTSGAAGHGSIQLSEFQ-----SPTSPN--PSETGTATTAELQAEPVYDNLGLRTTA 761
            ||...|           |:..:.||     .|.|.|  |.....|.:.|...:|
Zfish   612 PRQARW-----------SLFFNRFQFILTYRPGSKNLKPDALSRAYSPETHEKP----------- 654

  Fly   762 GGNSTLNLTKIAGSQGGAGQQYSMRDRPLPATPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQ 826
                                                 |||...:|:|..|:.   ...:|:.::.
Zfish   655 -------------------------------------VSSIIPSSRIVAPLR---WDLEQVVRKA 679

  Fly   827 QQQQQRLGSMDTEPLYGVRQQGITILPGSSISGAGLGHAAYLS--PGSGAAVS--------PS-- 879
            |.::...|:.....||..|.....:|.        .||.:.|:  |||...:.        ||
Zfish   680 QTKEPDPGNGPLGALYVPRAVRAQVLQ--------WGHESVLTCHPGSSRTLEFLRRRFWWPSIK 736

  Fly   880 --------------HASSSGDSPKAAKIPPRPPPKPKKKMS---VTTTRSGQGST 917
                          ...||...|:....|...|.:|...:|   :|.....||:|
Zfish   737 EDVKGYVEACQVCCQGKSSHQRPQGLLHPLPVPHRPWSHLSLDFITGLPLSQGNT 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064
		leucine-rich repeat	76..100	CDD:275380
		LRR_8	99..159	CDD:290566
		leucine-rich repeat	101..124	CDD:275380
		LRR	122..145	CDD:197688
		leucine-rich repeat	125..148	CDD:275380
		LRR_8	148..207	CDD:290566	9/39 (23%)
		leucine-rich repeat	149..172	CDD:275380	2/4 (50%)
		leucine-rich repeat	173..196	CDD:275380	2/22 (9%)
		LRR_8	197..>229	CDD:290566	7/43 (16%)
		leucine-rich repeat	197..220	CDD:275380	7/34 (21%)
		LRRCT	229..277	CDD:214507	20/103 (19%)
		Ig	296..376	CDD:143165	17/85 (20%)
lrfn4b	XP_021333806.1	retropepsin_like	58..144	CDD:133136	14/77 (18%)
		RT_LTR	253..429	CDD:238825	49/237 (21%)
		RNase_HI_RT_Ty3	525..646	CDD:260006	27/169 (16%)
		zf-H2C2	716..749	CDD:324145	5/32 (16%)
		rve	772..885	CDD:307008	5/19 (26%)
		Chromo	1069..1116	CDD:306815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26535
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910