DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and si:ch211-180f4.1

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001373634.1	Gene:	si:ch211-180f4.1 / 100144405	ZFINID:	ZDB-GENE-080327-27	Length:	744	Species:	Danio rerio

Alignment Length:	884	Identity:	174/884 - (19%)
Similarity:	279/884 - (31%)	Gaps:	311/884 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQ---WNSGK------KSADCKNKALTKIPQD 70
            :.|:|.|....:|:|           .| ..|.|:   |.:.:      |:.||....|::||.:
Zfish    13 VCLVLAVCRCSLAVP-----------FCPAQCVCETRPWYTPQSVYHQAKTVDCNELHLSRIPWN 66

  Fly    71 MSNEMQVLDFAHNQIP---------------ELRREEFLLAGLPNVHKIFLRNCT---------- 110
            :|.:.|||....|.|.               :|.:..|     ..:|.:.|.|.|
Zfish    67 ISVDTQVLLLQSNNISRGTSQLQSLVNLTELDLSQNHF-----TQIHDVGLNNLTQLVTLYLEEN 126

  Fly   111 -IQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLS 174
             |:|:.....|.|..|.||.::.|:|..:.|..|:||..|..:.:|:|::..:.:|.|.:|..|.
Zfish   127 QIKELPDMCLKDLVSLEELYINHNQISSIGPNAFSGLGNLLRLHLNSNKLVAIDSHWFESLPNLE 191

  Fly   175 RIEFRNN------------------------RLRQVQLHVFAGTMALSAISLEQNRLSHLHKETF 215
            .:....|                        .||::....|.|...|.::|...|:|:.:.|:..
Zfish   192 ILMIGENPILGLQDMNFHPLTKLHSLVLAGMGLREIPEGAFQGLEYLESLSFFDNKLTAVPKKAL 256

  Fly   216 KDLQKLMHLSLQGNAWNCSCELQ--DFRDF---------------AISKRLYTPPTDCQEPPQLR 263
            :.|..|..|.|..|.   ...:|  ||:||               |:.:..::     ..|...:
Zfish   257 RVLPSLKFLDLNKNP---IVRIQEGDFQDFPHLEELSLNNMEELVAVERGSFS-----NLPQMAK 313

  Fly   264 GKLWSEVPSENFACRPRIL--GSVRSFIEANHDNISLPCRIVGSPRPNV---------------- 310
            .:|::. |...|..|...|  ..:|:.:..|:|...||..|| |..||:
Zfish   314 LELYNN-PHLFFIDRAAFLKMRGLRTLLIHNNDLTLLPHEIV-SAFPNLDEISLHSNPLRCDCLN 376

  Fly   311 TW---VYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGA-YTCVADNRGGRA 371
            .|   :.|:..|:..:|::.:..|.:.:..|..|.:.|        ||..|| .||
Zfish   377 NWGPVLGNQSSLKVLEPQITLCASPQHLVGQALQDVVS--------ASWNGASNTC--------- 424

  Fly   372 EAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVL----TLF 432
                                   :..|......||.|:.|      ..||.|...||.    ..:
Zfish   425 -----------------------LPLISQHAFPPQLNVTL------GQLLTLDCWAVADPAPQFY 460

  Fly   433 WYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVI-----MEMQKSLLNEVNPVEKPPRR 492
            |            ...:||.:.|..:..:.|    ||...     |:.|.:|  |:..:|  |..
Zfish   461 W------------VTPTGDKVTSEAVSPSSN----EGGGTPKKHRMQDQGAL--EIPHIE--PED 505

  Fly   493 TDIE-----SVDGGDDVLEIKKTLLDDTVYV-------ANHSRDEEAVSVAMSDTTTTPRSRHTY 545
            |.:.     :.:|.|        ....:|||       |:|......|       ..|..|....
Zfish   506 TGLYTCVAWNAEGAD--------TRSVSVYVDKRSWNGAHHFGGHHGV-------VNTTGSLVIL 555

  Fly   546 VDDAYANSLPPDLLAFPARVPPT----SPSMQSSQSNIPD-QVIYGIRSPPSLTSPVYTHMTPHG 605
            ....:|.|:..:....|..:|..    .|...|:...|.: |:.|....|..:.....||:.|..
Zfish   556 AKTVHAQSVVLEWKMHPYAIPSNHEAGQPKWLSATVKIDNPQISYTAMVPVDVQEYNLTHLLPST 620

  Fly   606 IY-------GTK-------TMTAPHNGFMTLQHPKSRNLALIATTNS-----------------S 639
            .|       ||:       .:|.....|......:..|:||.|...|                 .
Zfish   621 EYQVCLTMAGTEQTQHSCINVTTKEASFAVEMVAQPTNVALAAVMGSMFAICIMALLVFYMGRRM 685

  Fly   640 RQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKP 704
            :|...||.|::..||                   |||  :|...:|.|...:
Zfish   686 KQKSCHHSLKKYMQH-------------------TTS--IPLNELYPPLINL------------- 716

  Fly   705 RAPSWAPSTSGAAGHGSIQLSEFQSPTSPNPSETGTATT 743
                |...|.          .|.:....|..|:..|:.|
Zfish   717 ----WENETE----------KEKEGAVDPQNSQIDTSKT 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	27/109 (25%)
		leucine-rich repeat	76..100	CDD:275380	7/38 (18%)
		LRR_8	99..159	CDD:290566	20/70 (29%)
		leucine-rich repeat	101..124	CDD:275380	8/33 (24%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	15/82 (18%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	6/46 (13%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	11/64 (17%)
		Ig	296..376	CDD:143165	21/99 (21%)
si:ch211-180f4.1	NP_001373634.1	leucine-rich repeat	51..70	CDD:275380	7/18 (39%)
		PPP1R42	55..266	CDD:411060	48/215 (22%)
		leucine-rich repeat	71..93	CDD:275380	5/21 (24%)
		leucine-rich repeat	94..117	CDD:275380	5/27 (19%)
		leucine-rich repeat	118..141	CDD:275380	4/22 (18%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		leucine-rich repeat	166..189	CDD:275380	6/22 (27%)
		leucine-rich repeat	190..213	CDD:275380	2/22 (9%)
		leucine-rich repeat	214..237	CDD:275380	4/22 (18%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	260..320	CDD:404697	12/68 (18%)
		leucine-rich repeat	262..285	CDD:275380	9/25 (36%)
		leucine-rich repeat	286..310	CDD:275380	1/28 (4%)
		leucine-rich repeat	311..330	CDD:275380	4/19 (21%)
		leucine-rich repeat	336..359	CDD:275378	8/23 (35%)
		PCC	341..>412	CDD:188093	16/71 (23%)
		leucine-rich repeat	360..372	CDD:275378	0/11 (0%)
		IG	434..528	CDD:214652	26/127 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910