DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and LRRC70

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_852607.3 Gene:LRRC70 / 100130733 HGNCID:35155 Length:622 Species:Homo sapiens


Alignment Length:297 Identity:81/297 - (27%)
Similarity:125/297 - (42%) Gaps:69/297 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 LTKIPQDMSNEMQV------LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGL 122
            |||:|   ||..:|      |..:||.|..:  :.|...||.|:..:.|:|..|:.|.|:.|.|:
Human   216 LTKVP---SNAFEVLKSLRRLSLSHNPIEAI--QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGI 275

  Fly   123 HILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQ 187
            :.|..|.||.|.:..|:..||:.|:.|..:.::.|.|..:.|..|.|:.                
Human   276 NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMG---------------- 324

  Fly   188 LHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDF----AISKR 248
                   .:|..::|..|.|:.||....|.|..|:||....|.|.|:|:|...||:    ||:..
Human   325 -------ASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLN 382

  Fly   249 LYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPN---- 309
            :|     ||.||.:||:....:         .|...|.|.|     |:|....:|.||..:    
Human   383 IY-----CQNPPSMRGRALRYI---------NITNCVTSSI-----NVSRAWAVVKSPHIHHKTT 428

  Fly   310 ---VTW---VYNKRPLQQYDPRVRVLTSVEQMPEQPS 340
               :.|   ..|..||:  :.....:|..|::|..|:
Human   429 ALMMAWHKVTTNGSPLE--NTETENITFWERIPTSPA 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 27/89 (30%)
leucine-rich repeat 76..100 CDD:275380 8/29 (28%)
LRR_8 99..159 CDD:290566 19/59 (32%)
leucine-rich repeat 101..124 CDD:275380 7/22 (32%)
LRR 122..145 CDD:197688 8/22 (36%)
leucine-rich repeat 125..148 CDD:275380 9/22 (41%)
LRR_8 148..207 CDD:290566 9/58 (16%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
leucine-rich repeat 173..196 CDD:275380 0/22 (0%)
LRR_8 197..>229 CDD:290566 11/31 (35%)
leucine-rich repeat 197..220 CDD:275380 8/22 (36%)
LRRCT 229..277 CDD:214507 16/51 (31%)
Ig 296..376 CDD:143165 12/55 (22%)
LRRC70NP_852607.3 LRRNT 31..62 CDD:214470
LRR 1 61..82
leucine-rich repeat 65..85 CDD:275380
LRR_8 85..144 CDD:290566
LRR 2 85..106
leucine-rich repeat 86..109 CDD:275380
LRR 3 109..130
leucine-rich repeat 110..133 CDD:275380
LRR_8 133..192 CDD:290566
LRR 4 133..154
leucine-rich repeat 134..157 CDD:275380
LRR 5 157..178
leucine-rich repeat 158..181 CDD:275380
LRR_RI <159..340 CDD:238064 41/151 (27%)
LRR 6 181..202
LRR_8 182..240 CDD:290566 10/26 (38%)
leucine-rich repeat 182..205 CDD:275380
LRR 7 205..226 6/12 (50%)
leucine-rich repeat 206..229 CDD:275380 7/15 (47%)
LRR_8 228..288 CDD:290566 20/61 (33%)
LRR 8 229..250 5/22 (23%)
leucine-rich repeat 230..253 CDD:275380 7/24 (29%)
LRR 9 253..274 7/20 (35%)
leucine-rich repeat 254..277 CDD:275380 7/22 (32%)
LRR_8 277..337 CDD:290566 18/82 (22%)
LRR 10 277..298 8/20 (40%)
leucine-rich repeat 278..301 CDD:275380 9/22 (41%)
LRR 11 301..322 5/20 (25%)
leucine-rich repeat 302..326 CDD:275380 6/46 (13%)
LRR 12 326..347 6/20 (30%)
leucine-rich repeat 327..348 CDD:275380 7/20 (35%)
LRRCT 359..398 CDD:214507 16/43 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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