DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	695	Identity:	140/695 - (20%)
Similarity:	230/695 - (33%)	Gaps:	255/695 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LPPPTAGTTDWMQSC--------------GTCHCQ-------WNSGK------KSADCKNKALTK 66
            :.||.     ||::|              |.|..|       |.:.:      |:.||.:..||.
Frog    12 MKPPL-----WMETCLFVIVLHSVFFSTLGVCPPQCVCETRPWFTPQSVYHEAKTVDCNDLLLTH 71

  Fly    67 IPQDMSNEMQVL----------------------------------------------------- 78
            ||:::|.::|||
Frog    72 IPENLSTDIQVLLLQSNKISHLTWELQELSNLTELDLSQNHFQSIDDLGVSNLSQLITLYLEENQ 136

  Fly    79 -----DFA-------------HNQI--------------------------------PELRREEF 93
                 |::             ||||                                .:|...|.
Frog   137 LRELPDYSLKDLGSLEELYINHNQISYIGPRAFSGLGRLLRLHLNANRLEIIDPRWFEDLPNLEI 201

  Fly    94 LLAG--------------LPNVHKIFLRNCTIQ------------------------EVHREAFK 120
            |:.|              |..:|.:.|....::                        ||.:||.|
Frog   202 LMVGENPVTALQSLNFQPLGRLHSLVLAGMELEHIPENAFQGLDYLESLSFFDNRLTEVPKEALK 266

  Fly   121 GLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINN-NEIEVLPNHLFVNLSFLSRIEFRNN-RL 183
            .|.:|..|||:.|.|.|:..|.|.|:|.|..:.:|: .|:|.:....|.:|..|.::|..|| ||
Frog   267 NLKLLKFLDLNKNPIPEIRGGDFTGMEHLEELSLNSMEELERVEAEAFQDLPELIKLEMCNNPRL 331

  Fly   184 RQVQLHVFAGTM-ALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISK 247
            ..:....|:..: ||..:.|..|||:.:..:.|:.|..|:.:||..|...|.|: ..::..:..:
Frog   332 SYLDPEAFSSNLGALKTLLLNNNRLAMVPLKIFQALPGLLEISLYSNPIRCDCQ-NCWKGLSKLR 395

  Fly   248 RLYTPPTDCQEPPQLRGKLWSEVPSENF--ACRPRILGSV--RSFIEANHDNISLPCRIVGSPRP 308
            .:....|.|..||.:.|.|:.|:..:.:  .|.|.|...:  ..|..|.|..:.|.|:..|.|:|
Frog   396 LIEAQATLCINPPLVSGHLFQEIQGQAWLNRCPPLIDTHLIPPQFQIARHQPVKLSCQASGHPKP 460

  Fly   309 NVTWV--YNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRA 371
            .:.|:  :.:| :...:.||::...             ..|.|......|.|:|||...|
Frog   461 EIYWMTPHGER-VTGTNGRVKINAG-------------GSLEITDAVEEDSGSYTCQMWN----- 506

  Fly   372 EAEFQLLVSGDYAGAVSASDGMGMGAIGAP---TIDPQTNMFLIICLIITTLLLLLLVAVLTLFW 433
                              |||....::...   |.:|:.     :.|::.|..:....||:.  |
Frog   507 ------------------SDGTDSKSVFVSINRTQEPEA-----MSLLMVTKKVHSNFAVVE--W 546

  Fly   434 YCRRIKTYQKDTTMMSGDGLI---------SSKMDKTHNGSM-LEGSVIMEMQKSLLNEVNPVEK 488
                        .|:||.|:.         ||...:.||..: ....|.:|:|:..|..:.|..|
Frog   547 ------------KMLSGSGVSPNVLVPFQWSSATMRIHNPHISYTAKVPLEVQEYNLTHLQPSTK 599

  Fly   489 PPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMS 533
            ......:.||........:..|..|.:..:|...|   .||:|:|
Frog   600 YEVCLTVSSVSQPSQQSCLNITTRDASFSMAVVGR---PVSIALS 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	35/225 (16%)
		leucine-rich repeat	76..100	CDD:275380	13/140 (9%)
		LRR_8	99..159	CDD:290566	21/84 (25%)
		leucine-rich repeat	101..124	CDD:275380	8/46 (17%)
		LRR	122..145	CDD:197688	10/22 (45%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	17/61 (28%)
		leucine-rich repeat	149..172	CDD:275380	6/23 (26%)
		leucine-rich repeat	173..196	CDD:275380	7/24 (29%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	10/49 (20%)
		Ig	296..376	CDD:143165	17/81 (21%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	25/209 (12%)
		leucine-rich repeat	60..79	CDD:275380	8/18 (44%)
		leucine-rich repeat	80..102	CDD:275380	3/21 (14%)
		LRR_8	101..161	CDD:316378	3/59 (5%)
		leucine-rich repeat	103..126	CDD:275380	0/22 (0%)
		leucine-rich repeat	127..150	CDD:275380	1/22 (5%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		leucine-rich repeat	175..198	CDD:275380	1/22 (5%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		leucine-rich repeat	223..246	CDD:275380	2/22 (9%)
		leucine-rich repeat	247..294	CDD:275380	16/46 (35%)
		LRR_8	294..356	CDD:316378	17/61 (28%)
		leucine-rich repeat	295..319	CDD:275380	6/23 (26%)
		leucine-rich repeat	320..345	CDD:275380	7/24 (29%)
		leucine-rich repeat	346..367	CDD:275380	6/20 (30%)
		PCC	351..>412	CDD:188093	16/61 (26%)
		leucine-rich repeat	370..382	CDD:275378	4/11 (36%)
		Ig	448..515	CDD:319273	20/103 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910