DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lrrc4b

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001096358.1	Gene:	lrrc4b / 100124949	XenbaseID:	XB-GENE-5945982	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	481	Identity:	111/481 - (23%)
Similarity:	175/481 - (36%)	Gaps:	136/481 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDF 80
            ||||.|..:.:....||        || ..|.|. |...:.| |..:.|.::|:.:|...:.|:.
Frog    24 LLLLWVTSLALGGISPT--------SCPAACTCS-NQASRVA-CTRRELMEVPESISVNTRYLNL 78

  Fly    81 AHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAG 145
            ..|.|..::.:.|  ..|.::..:.|....|:::...||.||..|..|:|..||:..:....|..
Frog    79 QENIIQVIKTDTF--KHLRHLEILQLSKNLIRKIEVGAFNGLPNLSTLELFDNRLTTVPTQAFEY 141

  Fly   146 LEKLRNVIINNNEIEVLPNHLF----------------------------VNLSFLS-------- 174
            |.|||.:.:.||.||.:|::.|                            |||.:|:
Frog   142 LSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKKLEYISEAAFEGLVNLRYLNLGMCNLKD 206

  Fly   175 -----------RIEFRNNRLRQVQLHVFAGTMALSAI-------------------SLEQNRLSH 209
                       .:|...|||..::...|.|..:|..:                   |||:..|||
Frog   207 IPNLTALVRLEELELSGNRLEMIRPGSFQGLTSLRKLWLMHAHVTIIERNAFDDLKSLEELNLSH 271

  Fly   210 -----LHKETFKDLQKLMHLSLQGNAWNCSCE-------LQDFRDFAISKRLYTPPTD------C 256
                 |..:.|..|.:|..:.|..|.|:|:|:       |::           |.|.:      |
Frog   272 NNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKE-----------TVPNNTTCCARC 325

  Fly   257 QEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHD-NIS------LPCRIVGSPRPNVTWVY 314
            ..||.|:.:...|:...:|.|...::      :|...| |::      |.|| .|:...:|.|:.
Frog   326 HSPPNLKMRYIGELDQSHFTCYAPVI------VEPPTDLNVTEGMAAELKCR-TGTSMTSVNWLT 383

  Fly   315 NKRPLQQYDP-RVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLL 378
            ....|..:.. |||:           |.:....|....|...|.|.|||:..|..|...|...|.
Frog   384 PNGTLMTHGSYRVRI-----------SVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTATATLN 437

  Fly   379 VSGDYAGAVSASDGMGMGAIGAPTID 404
            ||.  |...:.:|......:...|:|
Frog   438 VSA--AADPATTDYTYFTTVTVETMD 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/83 (28%)
		leucine-rich repeat	76..100	CDD:275380	5/23 (22%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	23/124 (19%)
		leucine-rich repeat	149..172	CDD:275380	11/50 (22%)
		leucine-rich repeat	173..196	CDD:275380	7/41 (17%)
		LRR_8	197..>229	CDD:290566	12/55 (22%)
		leucine-rich repeat	197..220	CDD:275380	10/46 (22%)
		LRRCT	229..277	CDD:214507	13/60 (22%)
		Ig	296..376	CDD:143165	21/86 (24%)
lrrc4b	NP_001096358.1	LRRNT	42..75	CDD:214470	9/34 (26%)
		leucine-rich repeat	73..96	CDD:275380	5/24 (21%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		PPP1R42	100..297	CDD:411060	44/196 (22%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..193	CDD:275380	0/23 (0%)
		leucine-rich repeat	194..215	CDD:275380	2/20 (10%)
		leucine-rich repeat	216..239	CDD:275380	6/22 (27%)
		leucine-rich repeat	240..263	CDD:275380	1/22 (5%)
		leucine-rich repeat	264..285	CDD:275380	7/20 (35%)
		LRRCT	296..346	CDD:214507	13/60 (22%)
		I-set	349..438	CDD:400151	25/106 (24%)
		Ig strand A	349..352	CDD:409353	0/8 (0%)
		Ig strand A'	356..359	CDD:409353	1/2 (50%)
		Ig strand B	365..372	CDD:409353	3/7 (43%)
		Ig strand C	378..383	CDD:409353	2/4 (50%)
		Ig strand C'	386..388	CDD:409353	0/1 (0%)
		Ig strand D	397..401	CDD:409353	2/14 (14%)
		Ig strand E	404..408	CDD:409353	1/3 (33%)
		Ig strand F	418..425	CDD:409353	3/6 (50%)
		Ig strand G	428..438	CDD:409353	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49155
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910