Protein Alignment nAChRalpha7 and HTR3B

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_006019.1
• Gene: HTR3B / 9177
• HGNCID: 5298
• Length: 441
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 128/538 - (23%)
• Similarity: 214/538 - (39%)
• Gaps: 140/538 - (26%)

  Fly    50 IMIP--AC---AAG--------PHEKRLLH---ALLDNYNSLERPVVNESDPLQLSFGLTLMQII 98
            :|.|  ||   |||        |.:..|.|   .||..|:...|||.|.:....:...|.:..|:
Human     5 VMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAIL 69

  Fly    99 DVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSAD-EGF-DGTY 161
            |||.:||:|.|::|.:..|||..|.||||.|..:|::.:|...:|.||:::....| |.: |..|
Human    70 DVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY 134

  Fly   162 ATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLD---LQLQDEAGG 223
               |.|.::|:.....|....|.|.::...||||.|.|.:.|.|..:....:|   |:..::...
Human   135 ---VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQH 196

  Fly   224 DISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALL 288
            |..:|:.:.||:||.|....:.:..:.  ..:..|.|.:::||..|.|..:|::|.:.:..:.|.
Human   197 DKKAFLNDSEWELLSVSSTYSILQSSA--GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLG 259

  Fly   289 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN-CIMFMVASSVVSTILI 352
            .|.|||:...::....::|:..|||...::..:|.:..:.||:|.:|. |:.|:|.|...|.:|:
Human   260 SFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324

  Fly   353 LNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVEL 417
            ...|..                         ||.||
Human   325 KFLHDE-------------------------QRGGQ----------------------------- 335

  Fly   418 KERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHE 482
                           :..|.|                    .:||..:      ..|.|:.|...
Human   336 ---------------EQPFLC--------------------LRGDTDA------DRPRVEPRAQR 359

  Fly   483 AISHTCLTSSAEY--------ELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLC---- 535
            |:    :|.|:.|        .|..:..:|:.|:..|:.:|:|.....:|.......|||.
Human   360 AV----VTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY 420

  Fly   536 LIIFTLFTIIATLAVLFS 553
            |.:..::||  ||..|::
Human   421 LFMLGIYTI--TLCSLWA 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	118/509 (23%)
		Neur_chan_LBD	61..268	CDD:280998	64/214 (30%)
		Neur_chan_memb	275..552	CDD:280999	53/289 (18%)
HTR3B	NP_006019.1	LIC	8..435	CDD:273305	126/532 (24%)
		Neur_chan_LBD	33..239	CDD:280998	63/210 (30%)
		Neur_chan_memb	246..>328	CDD:280999	22/81 (27%)
		HA-stretch	381..413		6/31 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910