Protein Alignment nAChRalpha7 and CHRFAM7A

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 200/471 - (42%)
• Similarity: 271/471 - (57%)
• Gaps: 96/471 - (20%)

  Fly   105 QLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRN 169
            ||||.::|:....                            |:     |||.||.|:.|||:|.:
Human    13 QLLIQHLWIAANC----------------------------DI-----ADERFDATFHTNVLVNS 44

  Fly   170 NGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEW 234
            :|.|.|:|||||||:|.||:.|||||.|.|::|||||:|.|:.||||:|:   .|||.:|.||||
Human    45 SGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE---ADISGYIPNGEW 106

  Fly   235 DLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEK 299
            ||:|:||||:|.:|.||.|||.|:||.:.:||:||||..||::|||||:::|||.|.||.|||||
Human   107 DLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEK 171

  Fly   300 LSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHE 364
            :|||:|:|||||||:.:|||.||||||:|||:..||...|.:|..|||.|:::|.|||.:||..:
Human   172 ISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGK 236

  Fly   365 MSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANV 429
            |.:|.|||.|.|....|||:|||                            |.|.|.:
Human   237 MPKWTRVILLNWCAWFLRMKRPG----------------------------EDKVRPA------- 266

  Fly   430 LDIDDDFRCNH---RCA------SATLPHQPTYYRTMY--RQGDDGSVGPVGPAGPVVDGRL--- 480
                    |.|   ||:      ||..|...:....:|  .:|.||......|...||.||:
Human   267 --------CQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACS 323

  Fly   481 ---HEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLF 542
               .|.:.|.......:.:||.||:|:|:|..:.:.:||:..:..:|||||.|||||||:.|::|
Human   324 PTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVF 388

  Fly   543 TIIATLAVLFSAPHFI 558
            |||.|:.:|.|||:|:
Human   389 TIICTIGILMSAPNFV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	194/459 (42%)
		Neur_chan_LBD	61..268	CDD:280998	75/162 (46%)
		Neur_chan_memb	275..552	CDD:280999	115/293 (39%)
CHRFAM7A	NP_647536.1	Neur_chan_LBD	<28..400	CDD:332142	190/417 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I3411
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1468
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm8451
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820