Protein Alignment nAChRalpha7 and CHRNA6

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 196/541 - (36%)
• Similarity: 291/541 - (53%)
• Gaps: 77/541 - (14%)

  Fly    35 TANGGRMLVYGLGLLIMI-----PACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTL 94
            |:.|...|..||.|.:.:     ..|.....|:||.|.|..:||...|||.|.|||:.:.|.:.:
Human     3 TSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAI 67

  Fly    95 MQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDG 159
            .|:.:|||.||::.||:||:..|||..|||:..|:.|:..||:|..::||||:::||:|...|..
Human    68 TQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQV 132

  Fly   160 TYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG- 223
            ...|..:::.||...:.||.||||:|.:|||:||||.|.|.:||||||||..::||.:   .|.
Human   133 EGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI---IGSK 194

  Fly   224 -DISSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMAL 287
             |::.|..|.||:::...|.:::|.||||.|.|.|||::..|||..::|..|||:||:.|:.:.:
Human   195 VDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTV 259

  Fly   288 LGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILI 352
            |.|.||.|.|||::|.:::||||||||.::.||:|:||..|||:|.|....|..|..|:|.|:.:
Human   260 LVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFV 324

  Fly   353 LNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRP----GQVGYECPP-----PPSSSSSSASGEK 408
            ||.|:|.|.||.|..|::.:||..||.:|.|:.|    ...|.:..|     .|:....::.||.
Human   325 LNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEP 389

  Fly   409 KQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASAT----LPHQPTYYRTMYRQGDDGSVGPV 469
            :      .|||               .|.|:.....||    |.|||..:
Human   390 R------HLKE---------------CFHCHKSNELATSKRRLSHQPLQW--------------- 418

  Fly   470 GPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRL 534
                 ||:...|..            |:..::..:::|.|.:|..:||.::..|||:.||||||:
Human   419 -----VVENSEHSP------------EVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRV 466

  Fly   535 CLIIFTLFTIIATLAVLFSAP 555
            .|.:|.:..:..| |.||..|
Human   467 FLWVFIIVCVFGT-AGLFLQP 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	184/503 (37%)
CHRNA6	NP_004189.1	LIC	34..484	CDD:455710	187/506 (37%)
		LGIC_ECD	34..240	CDD:475126	93/208 (45%)