DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and Htr3a

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006243083.1	Gene:	Htr3a / 79246	RGDID:	61818	Length:	488	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	153/512 - (29%)
Similarity:	230/512 - (44%)	Gaps:	82/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 RLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSS 127
            ||...||.||....|||.:...|..:|..:.:..|::||||||:|.|.||.:..|.|..|:|...
  Rat    41 RLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPE 105

  Fly   128 EFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWF 192
            :|..|..|.||...:|.||:|:....|.| .......|.|.:.|......|....:.|.:||..|
  Rat   106 DFDNVTKLSIPTDSIWVPDILINEFVDVG-KSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNF 169

  Fly   193 PFDDQRCEMKFGSWTYDGFQLDLQL---QDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEP 254
            |||.|.|.:.|.||.:....:::.|   .:|...|.|.||..|||:||||..|..|.... ....
  Rat   170 PFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIE-TSNS 233

  Fly   255 YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAE 319
            |.::.|.::|||:.|:|..:|::|.:.:..:.::||.|||||||::|..:|:||..:|||.:|::
  Rat   234 YAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSD 298

  Fly   320 TMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFL---YWLPCIL 381
            |:|||:...||:|.||...|.::..|:..||.|:...|:......:.:|:|.:.|   .||.|:
  Rat   299 TLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCL- 362

  Fly   382 RMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASAT 446
                                    ||:       .:..|...:..||..|         .|:.:.
  Rat   363 ------------------------GEQ-------PMAHRPPATFQANKTD---------DCSGSL 387

  Fly   447 LPHQPTYYRTMYRQGD--------DGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKE 503
            ||....:...:....|        |..:.|...|...|.|                     :|:|
  Rat   388 LPAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRG---------------------LLQE 431

  Fly   504 LRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIA---TLAVLFSAPHF 557
            |..|...|:|.||..::.|||.....|:|||...|: |..::|   ||..|:|..|:
  Rat   432 LSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIY-LLAVLAYSITLVTLWSIWHY 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	148/501 (30%)
		Neur_chan_LBD	61..268	CDD:280998	73/207 (35%)
		Neur_chan_memb	275..552	CDD:280999	75/290 (26%)
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	150/505 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910