Protein Alignment nAChRalpha7 and Htr3a

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_006243083.1
• Gene: Htr3a / 79246
• RGDID: 61818
• Length: 488
• Species: Rattus norvegicus
• Alignment Length: 512
• Identity: 153/512 - (29%)
• Similarity: 230/512 - (44%)
• Gaps: 82/512 - (16%)

  Fly    63 RLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSS 127
            ||...||.||....|||.:...|..:|..:.:..|::||||||:|.|.||.:..|.|..|:|...
  Rat    41 RLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPE 105

  Fly   128 EFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWF 192
            :|..|..|.||...:|.||:|:....|.| .......|.|.:.|......|....:.|.:||..|
  Rat   106 DFDNVTKLSIPTDSIWVPDILINEFVDVG-KSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNF 169

  Fly   193 PFDDQRCEMKFGSWTYDGFQLDLQL---QDEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCPEP 254
            |||.|.|.:.|.||.:....:::.|   .:|...|.|.||..|||:||||..|..|.... ....
  Rat   170 PFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIE-TSNS 233

  Fly   255 YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAE 319
            |.::.|.::|||:.|:|..:|::|.:.:..:.::||.|||||||::|..:|:||..:|||.:|::
  Rat   234 YAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSD 298

  Fly   320 TMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFL---YWLPCIL 381
            |:|||:...||:|.||...|.::..|:..||.|:...|:......:.:|:|.:.|   .||.|:
  Rat   299 TLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCL- 362

  Fly   382 RMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASAT 446
                                    ||:       .:..|...:..||..|         .|:.:.
  Rat   363 ------------------------GEQ-------PMAHRPPATFQANKTD---------DCSGSL 387

  Fly   447 LPHQPTYYRTMYRQGD--------DGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKE 503
            ||....:...:....|        |..:.|...|...|.|                     :|:|
  Rat   388 LPAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRG---------------------LLQE 431

  Fly   504 LRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIA---TLAVLFSAPHF 557
            |..|...|:|.||..::.|||.....|:|||...|: |..::|   ||..|:|..|:
  Rat   432 LSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIY-LLAVLAYSITLVTLWSIWHY 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	148/501 (30%)
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	150/505 (30%)