DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and chrna2a

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001035417.1	Gene:	chrna2a / 678575	ZFINID:	ZDB-GENE-040108-2	Length:	520	Species:	Danio rerio

Alignment Length:	559	Identity:	205/559 - (36%)
Similarity:	297/559 - (53%)	Gaps:	94/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RMLVYGLGLLIMI-----PACAAG---PH-EKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLM 95
            :.|:..|.:||:|     |..:.|   .| |.:|.|.|...||...|||.|.||.:.:.|||::.
Zfish     7 KTLLNNLWMLILIADHVQPVLSDGWIHAHAEDKLFHKLFIGYNKWSRPVRNISDVVIVKFGLSIA 71

  Fly    96 QIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGT 160
            |:||||||||::.||:|||.||||..||||.|||..|..:|:|...:|.||:::||:||..|..|
Zfish    72 QLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGEFAVT 136

  Fly   161 YATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDI 225
            :.|...:.:.|...:|||.|:||:|.||:|:||||.|.|:|||||||||..::||: |.|...|:
Zfish   137 HMTKAHLFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE-QIEGTVDL 200

  Fly   226 SSFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGF 290
            ..:..:|||.::...|..|...|:||.|.|.|||:..:|||..|:|..|||:||:||:.:.:|.|
Zfish   201 KDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVF 265

  Fly   291 TLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNY 355
            .||.|.|||::|.:::||||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:||.
Zfish   266 YLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNV 330

  Fly   356 HHRNPDTHEMSEWIRVIFLYWLPCILRMQRP-----------------------GQVGYECPP-- 395
            |||:|.||.|..|:..:||..:|..|.|:||                       |..|..|..
Zfish   331 HHRSPSTHSMPRWVHSVFLDHIPRWLFMRRPEPEKKPKKTANLSTSKSWFQQETGVDGLVCQDME 395

  Fly   396 -----PPSSSSSSAS----GEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQP 451
                 ..|.||.||:    .:.:..:|..||:.      |.:|:::     |.|......|..:|
Zfish   396 FGIGLSTSISSPSATSLHLSDSEPLLQKYELQH------LGHVVNL-----CQHPAKLGNLVSEP 449

  Fly   452 TYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDE 516
                                      |.|..    .|:..:        |:.:|:|.:.|:.|||
Zfish   450 --------------------------GLLFS----PCVLRA--------LEGVRYIADHLRAEDE 476

  Fly   517 TSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555
            ...:..|||:.|||:||:.|.:|.:..::.|:. ||..|
Zfish   477 DFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTIG-LFLPP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	194/523 (37%)
		Neur_chan_LBD	61..268	CDD:280998	100/206 (49%)
		Neur_chan_memb	275..552	CDD:280999	91/310 (29%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:273305	204/554 (37%)
		Neur_chan_LBD	37..243	CDD:280998	100/206 (49%)
		Neur_chan_memb	250..511	CDD:280999	91/310 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910