DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and Chrna9

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_075219.2	Gene:	Chrna9 / 65024	RGDID:	621534	Length:	479	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	170/504 - (33%)
Similarity:	268/504 - (53%)	Gaps:	56/504 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDM 120
            |.|.:.::|...|.::|:|..|||.:....|.::..:||.||.|:||:||:|...:|::..|:|.
  Rat    26 ANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDA 90

  Fly   121 NLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTC 185
            .|.|:..::..:..:|||...:|:||:::||.||:.......||||:|.:|...:..|.|.||:|
  Rat    91 YLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSC 155

  Fly   186 KIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIYYNC 250
            .:|:|:||||.|:|.:.||||||:|.|:|: ......||:|.||.:.||::.|:|..:|.|.|.|
  Rat   156 VVDVTYFPFDSQQCNLTFGSWTYNGNQVDI-FNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGC 219

  Fly   251 CPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLN 315
            |.|||.|:||.:|::|::.:|..||::|||||:.:|.|.|.||..||||:||||||||::|||..
  Rat   220 CSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQL 284

  Fly   316 MVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCI 380
            ||||.||| |:.|||:|.|:...|.::.:|...||:::|.|....:...:..|.:|:.|.::..|
  Rat   285 MVAEIMPA-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRI 348

  Fly   381 LRMQRPGQVGYECPPP-----PSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNH 440
            |.:.   .||..|..|     |...:...|...:..::....|:.|.|..:..:|..|
  Rat   349 LFVY---DVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKND------- 403

  Fly   441 RCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKELR 505
                  |.:|                           |.:.:.....|    |.||  .:.|.:.
  Rat   404 ------LGYQ---------------------------GGIPQNTDSYC----ARYE--ALTKNIE 429

  Fly   506 WITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSA 554
            :|.:.||....|:....:||..|.|:||..:.||.....:.|:.::..|
  Rat   430 YIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARA 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	166/493 (34%)
		Neur_chan_LBD	61..268	CDD:280998	83/206 (40%)
		Neur_chan_memb	275..552	CDD:280999	82/281 (29%)
Chrna9	NP_075219.2	LIC	8..474	CDD:273305	169/498 (34%)
Chrna9	NP_075219.2	LGIC_ECD_nAChR_A9	31..237	CDD:349823	83/206 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920