Protein Alignment nAChRalpha7 and lgc-24

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001123110.2
• Gene: lgc-24 / 6418837
• WormBaseID: WBGene00045385
• Length: 389
• Species: Caenorhabditis elegans
• Alignment Length: 341
• Identity: 66/341 - (19%)
• Similarity: 126/341 - (36%)
• Gaps: 70/341 - (20%)

  Fly    63 RLLHALLDNYNSLERPVVN----ESDP-LQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNL 122
            :|...|..|||. ..||..    |:.| |::.|    :..||.|.....::.|  .:|.|.|..|
 Worm    30 KLRSDLFKNYNG-SMPVGKGEYLEATPSLEVGF----IHFIDDDHGFMSVVIN--AELTWIDERL 87

  Fly   123 RWNSSEFGGVRDL-------RIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGI 180
            :||.:.:.|||::       | ..:..|.| ::.|.|.|..:.   ..:::..::...|....|.
 Worm    88 KWNPANYSGVREIVEKTFEFR-KDNNCWMP-IVKYRSYDRRYS---ELDLLEFSDARTLISYKGE 147

  Fly   181 FKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFIT-NG------------ 232
            .|:..:..:|      .:|:..||.:..|.....:.|......|...|:: ||
 Worm   148 IKTALQTMVT------TKCQFSFGEYPNDYQNCSIMLIPNQNADEFRFVSPNGYCNPKFENLEHR 206

  Fly   233 -----EWDLLGVPGKRNEIYYNCCPEPY-------------IDITFAILIRRKTLYYFFNLIVPC 279
                 :..|:||   .:.|:|......:             .:..|.::.:|........|.:|.
 Worm   207 AVRVHDLHLMGV---ESNIFYTFANTYFTAEEVTGFEYMAKTEFRFNLMFKRVNKLLNVKLSIPS 268

  Fly   280 VLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNM-VAETMPATSDAVPLLGTYFNCIMFMVA 343
            :||:...::....|  :|..: .|......:.|...: |::.:|.....:|..|....|  |::.
 Worm   269 ILISMFLIIAGLFP--NGYSI-FGYAYCFFVEVMHGLYVSKILPNDIRGIPYHGALALC--FLIE 328

  Fly   344 SSVVSTILILNYHHRN 359
            :..:....:.:.:.||
 Worm   329 TVFLFCWKVFSVYARN 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	66/341 (19%)
		Neur_chan_LBD	61..268	CDD:280998	50/247 (20%)
		Neur_chan_memb	275..552	CDD:280999	16/86 (19%)
lgc-24	NP_001123110.2	LGIC_ECD	62..226	CDD:355788	37/179 (21%)
		Cys-loop	160..174	CDD:349787	4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910