Protein Alignment nAChRalpha7 and htr3a

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_073791438.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 494
• Species: Danio rerio
• Alignment Length: 499
• Identity: 142/499 - (28%)
• Similarity: 242/499 - (48%)
• Gaps: 57/499 - (11%)

  Fly    63 RLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSS 127
            ||...|...|....|||.:......::..|.:..|::||||||:|.|.:|.:.:|.|..|.|:..
Zfish    40 RLNEFLSAGYKKGVRPVRDWRQSTTVAIDLMVYAILNVDEKNQVLTTYVWYRQQWTDEFLMWDPE 104

  Fly   128 EFGGVRDLRIPPHRLWKPDVLMYNSADEGF--DGTYATNVVVRNNGSCLYVPPGIFKSTCKIDIT 190
            ||..|:.:.||...:|.||:|:....|.|.  |..|   |.|.::|......|....:.|.::|.
Zfish   105 EFDEVKKISIPTANIWIPDILINEFVDVGKSPDIPY---VYVGHDGLVSNYKPIQVVTACSLNIY 166

  Fly   191 WFPFDDQRCEMKFGSWTYDGFQLDLQLQ---DEAGGDISSFITNGEWDLLGVPGKRNEIYYNCCP 252
            .||:|.|:|.:.|.||.:....:::.|.   :....|.|.|:..|||:||.|....|....: ..
Zfish   167 NFPYDVQKCSLTFQSWLHTTKDINITLMRSPEAVKTDKSVFMNQGEWELLHVLSTYNAFSID-ND 230

  Fly   253 EPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMV 317
            :.|.::.|.::|||:.|:|..||::|.:.:..|.::||.|||||||::|..:|:||..:|||.:|
Zfish   231 DYYAEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLPPDSGERVSFKITLLLGYSVFLIIV 295

  Fly   318 AETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILR 382
            ::|:|||:...||:|.||...|.::..|:..::||:...|:......:.:|::.:.|.....:|.
Zfish   296 SDTLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHKQDLQSRVPQWVKHLVLEKATVLLC 360

  Fly   383 MQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATL 447
            ::......:.      |..|.....|:..:...|  ::.:.:::.:.:      .|||.....:.
Zfish   361 IRNKKICSFR------SQGSDLPLYKENNMNTAE--QQDTLTMITSAI------HCNHHSCEGSR 411

  Fly   448 PHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLK 512
            ...    ||:   |...|....||  ||:||                     ||:|:..|.:.|:
Zfish   412 DSG----RTL---GLGLSAHESGP--PVMDG---------------------ILREITTIRQFLE 446

  Fly   513 KEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIA---TLAVLFS 553
            |:||:.:|.::|.....|:|.|...:: |.|::|   ||..|:|
Zfish   447 KKDESREIAKEWLQVGYVLDILLFRVY-LLTVLAYGITLGSLWS 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	138/492 (28%)
htr3a	XP_073791438.1	None