Protein Alignment nAChRalpha7 and CHRNA10

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_065135.2
• Gene: CHRNA10 / 57053
• HGNCID: 13800
• Length: 450
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 185/519 - (35%)
• Similarity: 267/519 - (51%)
• Gaps: 83/519 - (15%)

  Fly    42 LVYGLGLLIMIPA-C--AAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEK 103
            |..||.||.::|| |  |.|....:|...|..||.|..|||.:....|.::..:||.||||:||:
Human     8 LSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDER 72

  Fly   104 NQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVR 168
            ||:|...:|::.||.|..|||:.:.:||:..:|||...:|:||:::||.||....|:.:||||:|
Human    73 NQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLR 137

  Fly   169 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGE 233
            ::|:..:..|.|.:|:|::|:..||||.|.|.:.|||||:.|.|||::.:. |...::.|:.|.|
Human   138 HDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRG-AAASLADFVENVE 201

  Fly   234 WDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGE 298
            |.:||:|.:|..:.|.||.|||.|:||.:|:||:...|..||::|||||:.:|.|.|.||.||||
Human   202 WRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGE 266

  Fly   299 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTH 363
            |:|||||:||:||||..::||:|| .:::|||:|.|:...|.||..|...||||:|.|:..|...
Human   267 KVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330

  Fly   364 EMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLAN 428
            .:..|.|.:.|..|...|.::..|:...:..||..|.|
Human   331 PVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPS--------------------------- 368

  Fly   429 VLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRL---HEAISHTCLT 490
                               |..|           :|..||  ||||..:.|.   .||:.|...|
Human   369 -------------------PQSP-----------EGGAGP--PAGPCHEPRCLCRQEALLHHVAT 401

  Fly   491 SSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSA 554
                            |....:..........|||..|.|:||..|.||....::.:|.||..|
Human   402 ----------------IANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	171/491 (35%)
CHRNA10	NP_065135.2	LGIC_ECD	30..236	CDD:475126	87/206 (42%)
		LGIC_TM_cation	239..>324	CDD:349853	47/85 (55%)
		TM1 helix	239..261	CDD:349853	11/21 (52%)
		Neur_chan_memb	243..434	CDD:460753	80/266 (30%)
		TM2 helix	269..290	CDD:349853	13/20 (65%)
		TM3 helix	300..322	CDD:349853	9/21 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..380		9/83 (11%)