DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and chrna9a

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021326868.1	Gene:	chrna9a / 568807	ZFINID:	ZDB-GENE-090312-63	Length:	580	Species:	Danio rerio

Alignment Length:	583	Identity:	194/583 - (33%)
Similarity:	304/583 - (52%)	Gaps:	79/583 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LVYGLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQL 106
            ||..:.||:.....|.|...::||:.|::.|::..|||.:....|.::..:||.||.|:||:||:
Zfish     6 LVIHISLLLHAVFSAQGRFAQKLLNDLMEGYSNALRPVEDTDKALNVTLQITLSQIKDMDERNQV 70

  Fly   107 LITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSAD-EGFDGTYATNVVVRNN 170
            |.|.:|::..|:|..|.|:..|:.|:..:|||.:.:|:||:::||:|| |...|...||||:|.|
Zfish    71 LTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEEDSSGPPDTNVVLRYN 135

  Fly   171 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWD 235
            |...:..|.|.||:||:|:::||||.|.|.:.||||||:|.|:|:.:..|: ||:|.|:.|.||:
Zfish   136 GEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSWTYNGNQVDIAMGMES-GDLSDFVDNVEWE 199

  Fly   236 LLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKL 300
            ..|:|..:|.|.|.||.:||.|||:.:|::|::.:|.|||::||.||:.:|.|||.||.|||||:
Zfish   200 CHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPADSGEKV 264

  Fly   301 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEM 365
            |||||:||:||||..||||:|| .|::|||:|.|:...|.|:.:|...||.|:|.|....:...:
Zfish   265 SLGVTVLLALTVFQLMVAESMP-PSESVPLIGKYYIATMTMITASTSLTIFIMNIHFCGAEAKPV 328

  Fly   366 SEWIRVIFLYWLPCILRMQRPGQVGYECPPPPS------SSSSSASGEK-----KQQIQNVELKE 419
            ..|.:|:.:.::..|..:.   :||..|..|.|      |....||.|:     |...::..|.|
Zfish   329 PHWAKVLIIDYMSKIFFVY---EVGENCTTPESDRGPFFSEDPLASLERDGYFDKGFYEDCHLDE 390

  Fly   420 RSSKSLLANVLDIDDDFRCN-----------HR-------CASATLP-----HQPTYYRTMYRQG 461
            |.....  |.....|....|           ||       .:|:..|     |.|.|...:.|.|
Zfish   391 RIRSQF--NGYSHRDHRHGNGYHHKNSSYRQHRHEQQRRTRSSSNSPVRQSSHHPKYTHFIGRDG 453

  Fly   462 D------------DGSVG-PVGPAGPVVD---------GRLHE--------AISHTCLTSS---- 492
            .            |..:. |....|...|         |.||:        |.|:...|:.
Zfish   454 SEKLPLTSQEKLKDSEISIPEKINGYTYDQGNGYLNGVGYLHDNGYSKTFGADSYNKTTTGTGCV 518

  Fly   493 -AEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSA 554
             .:::  .:::.:.:|....:::........:||..|.|:||..:.:|.:...:.::.||..|
Zfish   519 CGKHQ--KLVRNIEYIANCFREQRGHQAKGAEWKKVAKVMDRFFMWVFFIMVFLMSILVLAKA 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	185/558 (33%)
		Neur_chan_LBD	61..268	CDD:280998	89/207 (43%)
		Neur_chan_memb	275..552	CDD:280999	94/345 (27%)
chrna9a	XP_021326868.1	Neur_chan_LBD	25..231	CDD:308532	88/206 (43%)
chrna9a	XP_021326868.1	Neur_chan_memb	239..>367	CDD:308533	56/131 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920