DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and chrnb4

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_696993.2	Gene:	chrnb4 / 568566	ZFINID:	ZDB-GENE-120809-1	Length:	525	Species:	Danio rerio

Alignment Length:	516	Identity:	188/516 - (36%)
Similarity:	292/516 - (56%)	Gaps:	56/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CAAGPHEKRLLHALL--DNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEW 117
            ||  ..|:||::.||  ..||.|.||.:|.::.:.:...::|.|:|.|:|:.|::.||:||...|
Zfish    33 CA--DSEERLMNWLLGKHRYNKLIRPALNRTERVTVLLQVSLAQLISVNEREQIMTTNVWLTQNW 95

  Fly   118 NDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFK 182
            ||..|.|:.:|:.|:..||||...:|.||:::||:||..::.|..||.:|..|||..::||.|:|
Zfish    96 NDYRLSWDPAEYEGIDKLRIPSRHIWLPDIVLYNNADGTYEVTVFTNAIVLFNGSIAWLPPAIYK 160

  Fly   183 STCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPGKRNEIY 247
            |.|||::..||||.|.|.:||.|||||..::||.|:.:| ..:..|..:||||:|.:||:|.
Zfish   161 SACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDLLLKSDA-ASMDDFTPSGEWDILALPGRRT--- 221

  Fly   248 YNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTV 312
            .:.....|:|:|:..:|:||.|:|..|||:|||||.|:|:|.|.||.|.|||::|.:::||:|||
Zfish   222 VSPLDATYVDLTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTV 286

  Fly   313 FLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWL 377
            ||.::::.:|.||..|||:|.|....|.:|..|:::::.:||.|||:|.||.|..|::::||..|
Zfish   287 FLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPSTHSMPAWVKIVFLVRL 351

  Fly   378 PCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRC 442
            |.:|.||||             ...||....:|..:.:.|.:...:|::           |:...
Zfish   352 PALLFMQRP-------------RGHSARQRLRQNRRLLGLADTPGRSVM-----------CSSAS 392

  Fly   443 A-----SATLPHQPTYYRTMYRQGDDGS------VGPVGPAGPVVDGRLHEAISHTCLTSSAEYE 496
            |     ||:....|   ..:|.:|..||      ....|.|..:...||:      |...|   |
Zfish   393 ALLAASSASALSSP---GLLYNKGHFGSRRAEGLNNGHGSAQDLKGNRLY------CEWGS---E 445

  Fly   497 LALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHF 557
            :...:..:|::.:.:...|:...:..|||:.|||||||.|.||.:..::.||. ||..|.|
Zfish   446 IQEAVDGVRYVADHMMGNDDDQSVIEDWKYVAMVVDRLFLWIFVIVCVVGTLG-LFLQPLF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	180/501 (36%)
		Neur_chan_LBD	61..268	CDD:280998	85/208 (41%)
		Neur_chan_memb	275..552	CDD:280999	93/287 (32%)
chrnb4	XP_696993.2	LIC	14..501	CDD:273305	185/510 (36%)
		Neur_chan_LBD	37..242	CDD:280998	85/208 (41%)
		Neur_chan_memb	249..500	CDD:280999	93/287 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910