Protein Alignment nAChRalpha7 and chrna3

DIOPT Version :10

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_073785858.1
• Gene: chrna3 / 568467
• ZFINID: ZDB-GENE-070822-1
• Length: 572
• Species: Danio rerio
• Alignment Length: 557
• Identity: 209/557 - (37%)
• Similarity: 315/557 - (56%)
• Gaps: 57/557 - (10%)

  Fly    22 SMSFPQPHSL--------PEATANGGRMLVY-----GLGLLIMIPACAAGPHEKRLLHALLDNYN 73
            |.|.|.|..:        |:.|.|.|.:|::     .|..|:....|:...|  ||...:..:||
Zfish    43 SSSSPGPPLVCTAALFLSPDCTMNTGALLIFFSSFSPLCFLLSGVCCSEAEH--RLFSVIFSSYN 105

  Fly    74 SLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIP 138
            ...|||.|.|||:.:.|.:::.|::.|||.||::.||:||:..|||..|||:..:||||..:|:|
Zfish   106 QYIRPVENVSDPVVVQFEVSMSQLVKVDEVNQIMETNLWLRHIWNDYKLRWDPKDFGGVEFIRVP 170

  Fly   139 PHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKF 203
            .:::||||:::||:|...|.....|..::|.||...::||.||||:||||:|:||||.|.|.|||
Zfish   171 SNKIWKPDIVLYNNAVGDFQVDDKTKALLRFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKF 235

  Fly   204 GSWTYDGFQLDLQLQDEAGGDIS--SFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRR 266
            ||||||..::||.|   .|..|:  .|..:|||.::..||.:::|.||||.|.|.|||:::.|||
Zfish   236 GSWTYDKAKIDLVL---IGSTINLKDFWESGEWTIIDAPGYKHDIKYNCCEEIYTDITYSLYIRR 297

  Fly   267 KTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLL 331
            ..|:|..|:|:||:||:.:.:|.|.||.|.|||::|.:::||||||||.::.||:|:||..:||:
Zfish   298 LPLFYTINMIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLI 362

  Fly   332 GTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECP-- 394
            |.|....|..|..|:|.|:.:||.|:|.|.||.|..|:|.:||..||.::.|.|| :...|.|
Zfish   363 GEYLLFTMIFVTLSIVITVFVLNVHYRTPKTHTMPCWVRRVFLSLLPRVMFMTRP-EKDQEVPAK 426

  Fly   395 -----PPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYY 454
                 ||.||..:|.....:..:...||.|.|..:.|..          .|.|       ...:.
Zfish   427 QCSVHPPVSSKQTSVCRGPQLLLCPTELNEASRTAFLCR----------EHHC-------WKKHI 474

  Fly   455 RTMYRQG-DDGSVGPVGPAGPVVDGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETS 518
            ..|..:| :||  |....:...:||.|       |: |:...::...::.:::|.|.::.::|..
Zfish   475 SNMTSEGAEDG--GSPCSSSESLDGFL-------CM-SAVSPQVREAIESVKYIAENMRLQNEAK 529

  Fly   519 DITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAP 555
            ::..|||:.|||:||:.|.:|.|..|:.| |.||..|
Zfish   530 EVQDDWKYVAMVIDRIFLWVFVLVCILGT-AGLFLQP 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:455710	192/498 (39%)
chrna3	XP_073785858.1	None