Protein Alignment nAChRalpha7 and chrna3

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_001921314.1
• Gene: chrna3 / 568467
• ZFINID: ZDB-GENE-070822-1
• Length: 508
• Species: Danio rerio
• Alignment Length: 534
• Identity: 203/534 - (38%)
• Similarity: 307/534 - (57%)
• Gaps: 49/534 - (9%)

  Fly    37 NGGRMLVY-----GLGLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQ 96
            |.|.:|::     .|..|:....|:...|  ||...:..:||...|||.|.|||:.:.|.:::.|
Zfish     2 NTGALLIFFSSFSPLCFLLSGVCCSEAEH--RLFSVIFSSYNQYIRPVENVSDPVVVQFEVSMSQ 64

  Fly    97 IIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTY 161
            ::.|||.||::.||:||:..|||..|||:..:||||..:|:|.:::||||:::||:|...|....
Zfish    65 LVKVDEVNQIMETNLWLRHIWNDYKLRWDPKDFGGVEFIRVPSNKIWKPDIVLYNNAVGDFQVDD 129

  Fly   162 ATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDIS 226
            .|..::|.||...::||.||||:||||:|:||||.|.|.|||||||||..::||.|   .|..|:
Zfish   130 KTKALLRFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL---IGSTIN 191

  Fly   227 --SFITNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLG 289
              .|..:|||.::..||.:::|.||||.|.|.|||:::.|||..|:|..|:|:||:||:.:.:|.
Zfish   192 LKDFWESGEWTIIDAPGYKHDIKYNCCEEIYTDITYSLYIRRLPLFYTINMIIPCLLISFLTVLV 256

  Fly   290 FTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILN 354
            |.||.|.|||::|.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:||
Zfish   257 FYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN 321

  Fly   355 YHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECP-------PPPSSSSSSASGEKKQQI 412
            .|:|.|.||.|..|:|.:||..||.::.|.|| :...|.|       ||.||..:|.....:..:
Zfish   322 VHYRTPKTHTMPCWVRRVFLSLLPRVMFMTRP-EKDQEVPAKQCSVHPPVSSKQTSVCRGPQLLL 385

  Fly   413 QNVELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQG-DDGSVGPVGPAGPVV 476
            ...||.|.|..:.|..          .|.|       ...:...|..:| :||  |....:...:
Zfish   386 CPTELNEASRTAFLCR----------EHHC-------WKKHISNMTSEGAEDG--GSPCSSSESL 431

  Fly   477 DGRLHEAISHTCLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTL 541
            ||.|       |: |:...::...::.:::|.|.::.::|..::..|||:.|||:||:.|.:|.|
Zfish   432 DGFL-------CM-SAVSPQVREAIESVKYIAENMRLQNEAKEVQDDWKYVAMVIDRIFLWVFVL 488

  Fly   542 FTIIATLAVLFSAP 555
            ..|:.| |.||..|
Zfish   489 VCILGT-AGLFLQP 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	192/498 (39%)
		Neur_chan_LBD	61..268	CDD:280998	96/208 (46%)
		Neur_chan_memb	275..552	CDD:280999	94/284 (33%)
chrna3	XP_001921314.1	LIC	4..499	CDD:273305	200/528 (38%)
		Neur_chan_LBD	29..235	CDD:280998	97/210 (46%)
		Neur_chan_memb	242..498	CDD:280999	94/284 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910