Protein Alignment nAChRalpha7 and chrna11

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 591
• Identity: 242/591 - (40%)
• Similarity: 349/591 - (59%)
• Gaps: 99/591 - (16%)

  Fly    47 GLLIMIPACAAGPHEKRLLHALLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITNI 111
            |:..:|.....||:::.||..||.:||.:||||.|:|.||.:...::|:||:|||||||:|.|||
Zfish    11 GISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEKNQVLTTNI 75

  Fly   112 WLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYV 176
            ||.:.|.|..|:||.||:.||::||....::|.||:|:|||||:.||.|:.:||||.::|.|.|:
Zfish    76 WLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVNSSGYCNYL 140

  Fly   177 PPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLGVPG 241
            |||||.|||.:|:.|||||.|:||:||||||:||:.||||:.:   .|||.::.||||||:||||
Zfish   141 PPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE---ADISGYMPNGEWDLVGVPG 202

  Fly   242 KRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSLGVTI 306
            .|||::|:||.|||.|:||.:.|||:||||..||::||||::||.||.|.||.|||||:|||:|:
Zfish   203 TRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFLLPADSGEKISLGITV 267

  Fly   307 LLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRV 371
            |||||||:.:|||.||||||::||:|.||..||.:|..||::|:::|.|||.:|:...|.:|:::
Zfish   268 LLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATVVVLQYHHHDPNGGNMPKWVQL 332

  Fly   372 IFLYWLPCILRMQRPGQ-VGYECPPPPSSSSSSASGEKKQQIQNV-------------------- 415
            :.|.|:...|||:|||: ...|.||........:||.:...:.|.
Zfish   333 VLLQWVAWFLRMKRPGESEDPERPPCAPHLRRCSSGSQSGSLPNAPGSASADLHHHHISSTLHPL 397

  Fly   416 -------------------------------------ELKERSSKSLLANVLDIDDDFRCNHR-- 441
                                                 .|.|.|..:|||      |..:.|..
Zfish   398 HPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIGFSSLDEASPPALLA------DSVQRNSMSG 456

  Fly   442 -----------CASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGR-LHEAISH-----TCL 489
                       ..|:..||.|:.:           ..|..|..|.::.. ....:|.     :|.
Zfish   457 GPRPTVVSPPVVGSSPPPHLPSQF-----------CSPPPPPTPNLEATGCPSTVSGGGGGCSCS 510

  Fly   490 TSS--AEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLF 552
            .:|  .:.:|..||:|:|::.::.:.:||...:|..|||||.|:|||||:.|::|.||.|:::|.
Zfish   511 GTSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVIDRLCLVAFSVFNIICTISILM 575

  Fly   553 SAPHFI 558
            |||:|:
Zfish   576 SAPNFV 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	233/567 (41%)
		Neur_chan_LBD	61..268	CDD:280998	117/206 (57%)
		Neur_chan_memb	275..552	CDD:280999	111/355 (31%)
chrna11	NP_001038562.1	LIC	2..577	CDD:273305	238/585 (41%)
		Neur_chan_LBD	25..229	CDD:280998	117/206 (57%)
		Neur_chan_memb	236..573	CDD:280999	111/353 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134707
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840