Protein Alignment nAChRalpha7 and chrnb2

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_005169811.1
• Gene: chrnb2 / 561906
• ZFINID: ZDB-GENE-070821-3
• Length: 543
• Species: Danio rerio
• Alignment Length: 551
• Identity: 192/551 - (34%)
• Similarity: 298/551 - (54%)
• Gaps: 71/551 - (12%)

  Fly    48 LLIMIPACAAGPHEKRLLHALLD--NYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQLLITN 110
            :|.::.:......|:||:..||:  :||.|.||..|.|:.:.:...::|.|:|.|.|:.|::.||
Zfish    10 ILAIVKSGYGADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHEREQIMTTN 74

  Fly   111 IWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLY 175
            :||..||.|..|.|:..||.|::.:|:|...:|.|||::||:||..::.::.:|.||..:||..:
Zfish    75 VWLTQEWQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSVFW 139

  Fly   176 VPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISS---FITNGEWDLL 237
            :||.|:||.|||::..||||.|.|.:.|.|||||..::||.|:    .|::|   |..:||||::
Zfish   140 LPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVLR----ADVASMDDFTPSGEWDII 200

  Fly   238 GVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKLSL 302
            .:||:|||   |.....|:|||:..:||||.|:|..|||:|||||.|:|:|.|.||.|.|||::|
Zfish   201 ALPGRRNE---NPSDPTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTL 262

  Fly   303 GVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSE 367
            .:::||:|||||.::::.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:|.||.|..
Zfish   263 CISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMPP 327

  Fly   368 WIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSKSLLANVL-- 430
            |::::||..||.:|.|::|             .:||.....:|:.:..|.:|.....|.|.::
Zfish   328 WVKLVFLNKLPALLFMRQP-------------RNSSERQRLRQRRRANEQQEGGRGGLAAGLMAG 379

  Fly   431 -----DIDDDFRCNHRCASATLPHQPTYY--RTMYRQ---------GDDGSVGPV---------- 469
                 ........|..|         |.|  |...:|         |..||...:
Zfish   380 LGLSGSSSGSKENNEAC---------TCYVNRASVKQFGAELGGGGGGGGSTDGLNGIREGGRET 435

  Fly   470 --GPAGPVVDGRLHEAISH--TCLTSSAEYELALILKE----LRWITEQLKKEDETSDITRDWKF 526
              |.|.|:....|......  |.||.:...:.....:|    :|:|...:|.||:...::.|||:
Zfish   436 REGGANPLQGSALPRGKQQPPTVLTQALLAQACPGFEEAVDGVRFIANHMKSEDDDRSVSEDWKY 500

  Fly   527 AAMVVDRLCLIIFTLFTIIATLAVLFSAPHF 557
            .|||:|||.|.||....:..|:. :|..|.|
Zfish   501 VAMVIDRLFLWIFVFVCVFGTIG-MFLQPLF 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	187/529 (35%)
		Neur_chan_LBD	61..268	CDD:280998	88/211 (42%)
		Neur_chan_memb	275..552	CDD:280999	96/312 (31%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:273305	189/545 (35%)
		Neur_chan_LBD	23..228	CDD:280998	88/211 (42%)
		Neur_chan_memb	235..525	CDD:280999	96/312 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910