DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha7 and Chrna10

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001074893.1	Gene:	Chrna10 / 504186	MGIID:	3609260	Length:	447	Species:	Mus musculus

Alignment Length:	522	Identity:	183/522 - (35%)
Similarity:	264/522 - (50%)	Gaps:	98/522 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GLGLLIMIPACAAGPHEKRLLHA----LLDNYNSLERPVVNESDPLQLSFGLTLMQIIDVDEKNQ 105
            |..||:.:||...|. |.||.|.    |..||.|..|||.:....|.::..:||.||||:||:||
Mouse    11 GFLLLLFLPAECLGA-EGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQ 74

  Fly   106 LLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNN 170
            :|...:|::.||.|..|.|:...:|.:..:|||...:|:||:::||.||.....:.:||||||::
Mouse    75 VLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHD 139

  Fly   171 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWD 235
            |:..:..|.|.:|:|::|::.||||.|||.:.|||||:.|.|||::.:. ....::.|:.|.||.
Mouse   140 GAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRG-TSASLADFVENVEWR 203

  Fly   236 LLGVPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGEKL 300
            :||:|.:|..:.|.||.|||.|:||.:|:||:...|..||::|||.|:.:|.|.|.||.|||||:
Mouse   204 VLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKV 268

  Fly   301 SLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDTHEM 365
            |||||:||:||||..::||:|| .:::|||:|.|:...|.||..|...||||:|.|:..|:.|.:
Mouse   269 SLGVTVLLALTVFQLILAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPV 332

  Fly   366 SEWIRVIFLYWLP---CILRMQRP-GQ-VGYECPP---PPSSSSSSASGEKKQQIQNVELKERSS 422
            ..|.||:.|..|.   |:.....| || ...|..|   ||:...:....|.:....        .
Mouse   333 PAWARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPAGPPAGPCHEPRCLCH--------Q 389

  Fly   423 KSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHT 487
            ::||.:|..|...|| :||.|.                                  |.||
Mouse   390 EALLHHVASIAGTFR-SHRAAQ----------------------------------RRHE----- 414

  Fly   488 CLTSSAEYELALILKELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLF 552
                                               |||..|.|:||..|.||....::.:|.||.
Mouse   415 -----------------------------------DWKRLARVMDRFFLGIFFCMALVMSLLVLV 444

  Fly   553 SA 554
            .|
Mouse   445 QA 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	173/500 (35%)
		Neur_chan_LBD	61..268	CDD:280998	88/210 (42%)
		Neur_chan_memb	275..552	CDD:280999	85/284 (30%)
Chrna10	NP_001074893.1	LGIC_ECD	30..236	CDD:355788	85/206 (41%)
		LGIC_TM_cation	239..>324	CDD:349853	46/85 (54%)
		TM1 helix	239..261	CDD:349853	10/21 (48%)
		Neur_chan_memb	243..437	CDD:367256	83/277 (30%)
		TM2 helix	269..290	CDD:349853	13/20 (65%)
		TM3 helix	300..322	CDD:349853	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920