Protein Alignment nAChRalpha7 and ort

DIOPT Version :9

• Sequence 1: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 114/558 - (20%)
• Similarity: 209/558 - (37%)
• Gaps: 152/558 - (27%)

  Fly    42 LVYGLGLLIMIPAC----AAGPHEKRLLHALLD-------NYNSLERPVVNESDPLQLSFGLTLM 95
            :|:.:.:|::...|    |.|..::.|  |:.|       .|:.: ||...|..|..:.|.:|:|
  Fly     1 MVFQIIILVICTICMKHYAKGEFQQSL--AITDILPEDIKRYDKM-RPPKKEGQPTIVYFHVTVM 62

  Fly    96 QIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRIP-PHRLWKPDVLMYNSADEGFDG 159
            .:..:||.:...:.:::....|.|..||...:.....|.|.:. ...:|:||....|:....|..
  Fly    63 GLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQT 127

  Fly   160 TYATN--VVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDG----FQLDLQLQ 218
            ....|  :.:..:.:.||:.....|.:|.::...:|.|.|.|:::..|.::..    ||.|
  Fly   128 MTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWD---- 188

  Fly   219 DEAGGDISSFITNGEWDLLGVPGKRNE------IY----YNCCPEPYIDITFAILIRRKTLYYFF 273
                 ..:..:.:...:|..|...|||      :|    :.|     :::.|.  ::|:.:||.|
  Fly   189 -----PTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTC-----LEVVFT--LKRRLVYYVF 241

  Fly   274 NLIVPCVLIASMALLGFTLPPDSG-EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNC 337
            |..:|..:|..|:.:.|.:.|::. .:::||||.||:|:........::|..|        |...
  Fly   242 NTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVS--------YLKA 298

  Fly   338 I-MFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRM-----QRPGQVGYECPP- 395
            : .||...:|...:.::.|                       |::.:     ..|..:.|  ||
  Fly   299 VDAFMSVCTVFVFMALMEY-----------------------CLINIVLSDTPIPKPMAY--PPK 338

  Fly   396 --------------PPSSSSSSASGEKKQQIQNVELKERSSKSLLANVLDIDDDFRCNHRCASAT 446
                          ||..|:|:||   |||...:.|.:..    :..:..|.|:...|.|..:.|
  Fly   339 PVAGDGPKKEGEGAPPGGSNSTAS---KQQATMLPLADEK----IEKIEKIFDEMTKNRRIVTTT 396

  Fly   447 LPHQPTYYRTMYRQGDDGSVGPVGPAGPVVDGRLHEAISHTCLTSS----------AEYELALIL 501
                    |.:.|...|..    ||..|..:.|:       .||.:          |..|..|..
  Fly   397 --------RRVVRPPLDAD----GPWIPRQESRI-------ILTPTIAPPPPPPQPAAPEPELPK 442

  Fly   502 KELRWITEQLKKEDETSDITRDWKFAAMVVDRLCLIIF 539
            .:|....|:||:              |:.:||...::|
  Fly   443 PKLTPAQERLKR--------------AIYIDRSSRVLF 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	109/537 (20%)
		Neur_chan_LBD	61..268	CDD:280998	46/230 (20%)
		Neur_chan_memb	275..552	CDD:280999	59/297 (20%)
ort	NP_524406.1	LIC	31..481	CDD:273305	107/526 (20%)
		Neur_chan_LBD	38..235	CDD:280998	42/213 (20%)
		Neur_chan_memb	243..>334	CDD:280999	21/121 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100