DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha7 and NtR

DIOPT Version :9

Sequence 1:	NP_001162795.1	Gene:	nAChRalpha7 / 32928	FlyBaseID:	FBgn0086778	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	78/357 - (21%)
Similarity:	132/357 - (36%)	Gaps:	42/357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 DNYNSLERPVV------------------NESDPLQL---SFGLTLMQIIDVDEKNQLLITNIWL 113
            |.|.|...|:|                  |.|.|..|   ||......:. .::.:.||.|.:.:
  Fly   200 DGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLA-YEQTSSLLQTRMHM 263

  Fly   114 KLEWNDMNLRWNSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYAT-NVVVRNNGS-CLYV 176
            .:.|.|..|.|...:||.:.....|..|:|||.:.:.|.|.:.......: .::|..||| .||.
  Fly   264 MMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYA 328

  Fly   177 PPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDIS---SFITNGEWDL-- 236
            ......|.|......:|.:...|:::.|....:|.:....:.|:....|:   ...|...|..
  Fly   329 QNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSFTQ 393

  Fly   237 LGVPGKRNEIYYNCCPEPYI-----DITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDS 296
            :.|....|:......|:..:     |:.....::|...:|.....:|.:......:|.|.|  .|
  Fly   394 MSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVL--RS 456

  Fly   297 GEKLSLGVTILLSLTVFL-NMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNP 360
            ..:.||   ||::|.:.. .::..|..|:...||.:.|.:..||.......:..|.|: :....|
  Fly   457 TRRSSL---ILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYCYILHICII-WLDLYP 517

  Fly   361 DTHEMSEW-IRVIFLYWLPCILRMQRPGQVGY 391
            ...:...| :|||....|.|||.::......|
  Fly   518 PRSKAPGWLVRVINSNVLRCILGLRFSDSTDY 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	78/357 (22%)
		Neur_chan_LBD	61..268	CDD:280998	48/230 (21%)
		Neur_chan_memb	275..552	CDD:280999	29/119 (24%)
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	42/217 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010